Assessment of Structural Intolerance and Durability
General Structure Information 2fbv WRN wrn exonuclease, mn complex 2.4Å AUTH J.J.PERRY,S.M.YANNONE,L.G.HOLDEN,C.HITOMI,AUTH 2 A.ASAITHAMBY,S.HAN,P.K.COOPER,D.J.CHEN,J.A.TAINERTITL WRN EXONUCLEASE STRUCTURE AND MOLECULAR MECHANISMTITL 2 IMPLY AN EDITING ROLE IN DNA END PROCESSING.REF NAT.STRUCT.MOL.BIOL. V. 13 414 2006REFN ISSN 1545-9993PMID 16622405DOI 10.1038/NSMB1088 Variant Set Distributions Mapped Variants
General Structure Information 2jzx PCBP2 pcbp2 kh1-kh2 domains -1.0Å AUTH Z.DU,S.FENN,R.TJHEN,T.JAMESTITL STRUCTURE OF THE FIRST AND SECOND KH DOMAINS OF HUMAN POLY-CTITL 2 BINDING PROTEIN-2 REVEALS INSIGHTS INTO ITS REGULATORYTITL 3 MECHANISMSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ujy ARHGEF6 solution structure of sh3 domain in rac/cdc42 guanine nucleotide exchange factor(gef) 6 -1.0Å AUTH F.HE,Y.MUTO,H.UDA,S.KOSHIBA,M.SHIROUZU,T.TERADA,AUTH 2 T.KIGAWA,M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,AUTH 3 H.HIROTA,M.YOSHIDA,N.KOBAYASHI,A.TANAKA,T.OSANAI,AUTH 4 Y.MATSUO,O.OHARA,T.NAGASE,R.KIKUNO,M.NAGAYAMA,AUTH 5 S.YOKOYAMATITL SOLUTION STRUCTURE OF SH3 DOMAIN IN RAC/CDC42TITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR(GEF) 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1cf7 TFDP2 structural basis of dna recognition by the heterodimeric cell cycle transcription factor e2f-dp 2.6Å AUTH N.ZHENG,E.FRAENKEL,C.O.PABO,N.P.PAVLETICHTITL STRUCTURAL BASIS OF DNA RECOGNITION BY THETITL 2 HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTORTITL 3 E2F-DP.REF GENES DEV. V. 13 666 1999REFN ISSN 0890-9369PMID 10090723 Variant Set Distributions Mapped Variants
General Structure Information 2oeh ARID5B determination of the three-dimensional structure of the mrf2-dna complex using paramagnetic spin labeling -1.0Å AUTH S.CAI,L.ZHU,Z.ZHANG,Y.CHENTITL DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURETITL 2 OF THE MRF2-DNA COMPLEX USING PARAMAGNETIC SPINTITL 3 LABELING.REF BIOCHEMISTRY V. 46 4943 2007REFN ISSN 0006-2960PMID 17407261DOI 10.1021/BI061738H Variant Set Distributions Mapped Variants
General Structure Information 4iz5 PEA15 structure of the complex between erk2 phosphomimetic mutant and pea-15 3.19Å AUTH P.D.MACE,Y.WALLEZ,M.F.EGGER,M.K.DOBACZEWSKA,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL STRUCTURE OF ERK2 BOUND TO PEA-15 REVEALS A MECHANISM FORTITL 2 RAPID RELEASE OF ACTIVATED MAPK.REF NAT COMMUN V. 4 1681 2013REFN ESSN 2041-1723PMID 23575685DOI 10.1038/NCOMMS2687 Variant Set Distributions Mapped Variants
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2ux0 CAMK2G structure of the oligomerisation domain of calcium- calmodulin dependent protein kinase ii gamma 2.46Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 4i6x PDIA5 crystal structure of non-catalyic domain of protein disulfide isomerase-related (pdir) protein 1.5Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL STRUCTURE OF THE NON-CATALYTIC DOMAIN OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN (PDIR) REVEALS FUNCTIONTITL 3 IN PROTEIN BINDING.REF PLOS ONE V. 8 62021 2013REFN ESSN 1932-6203PMID 23614004DOI 10.1371/JOURNAL.PONE.0062021 Variant Set Distributions Mapped Variants
General Structure Information 2k1m MYBPC3 3d nmr structure of domain cc0 of cardiac myosin binding protein c (mybpc) -1.0Å AUTH J.RATTI,M.GAUTEL,M.PFUHLTITL 3D NMR STRUCTURE OF DOMAIN CC0 OF CARDIAC MYOSINTITL 2 BINDING PROTEIN C (MYBPC)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants