Assessment of Structural Intolerance and Durability
General Structure Information 2vn9 CAMK2D crystal structure of human calcium calmodulin dependent protein kinase ii delta isoform 1, camkd 2.3Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 4cnc TPBG crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein) 1.77Å AUTH Y.ZHAO,T.MALINAUSKAS,K.HARLOS,E.Y.JONESTITL STRUCTURAL INSIGHTS INTO THE INHIBITION OF WNT SIGNALING BYTITL 2 CANCER ANTIGEN 5T4/WNT-ACTIVATED INHIBITORY FACTOR 1.REF STRUCTURE V. 22 612 2014REFN ISSN 0969-2126PMID 24582434DOI 10.1016/J.STR.2014.01.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3oxq CACNA1C crystal structure of ca2+/cam-cav1.2 pre-iq/iq domain complex 2.55Å AUTH E.Y.KIM,C.H.RUMPF,F.VAN PETEGEM,R.J.ARANT,F.FINDEISEN,AUTH 2 E.S.COOLEY,E.Y.ISACOFF,D.L.MINORTITL MULTIPLE C-TERMINAL TAIL CA(2+)/CAMS REGULATE CA(V)1.2TITL 2 FUNCTION BUT DO NOT MEDIATE CHANNEL DIMERIZATION.REF EMBO J. V. 29 3924 2010REFN ISSN 0261-4189PMID 20953164DOI 10.1038/EMBOJ.2010.260 Variant Set Distributions Mapped Variants
General Structure Information 1xv9 NR1I3 crystal structure of car/rxr heterodimer bound with src1 peptide, fatty acid, and 5b-pregnane-3,20-dione. 2.7Å AUTH R.X.XU,M.H.LAMBERT,B.B.WISELY,E.N.WARREN,AUTH 2 E.E.WEINERT,G.M.WAITT,J.D.WILLIAMS,J.L.COLLINS,AUTH 3 L.B.MOORE,T.M.WILLSON,J.T.MOORETITL A STRUCTURAL BASIS FOR CONSTITUTIVE ACTIVITY INTITL 2 THE HUMAN CAR/RXRALPHA HETERODIMER.REF MOL.CELL V. 16 919 2004REFN ISSN 1097-2765PMID 15610735DOI 10.1016/J.MOLCEL.2004.11.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2emw ZNF268 solution structure of the c2h2 type zinc finger (region 301- 331) of human zinc finger protein 268 -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 301-331) OF HUMAN ZINC FINGER PROTEIN 268REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fb2 SPTAN1 crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target hr5563a. 2.3Å AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,R.SHASTRY,AUTH 2 E.L.FOOTE,C.CICCOSANTI,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE HUMAN BRAIN ALPHATITL 2 SPECTRIN REPEATS 15 AND 16.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4ddp BECN1 crystal structure of beclin 1 evolutionarily conserved domain(ecd) 1.55Å AUTH W.HUANG,W.CHOI,W.HU,N.MI,Q.GUO,M.MA,M.LIU,Y.TIAN,P.LU,AUTH 2 F.L.WANG,H.DENG,L.LIU,N.GAO,L.YU,Y.SHITITL CRYSTAL STRUCTURE AND BIOCHEMICAL ANALYSES REVEAL BECLIN 1TITL 2 AS A NOVEL MEMBRANE BINDING PROTEINREF CELL RES. 2012REFN ISSN 1001-0602PMID 22310240DOI 10.1038/CR.2012.24 Variant Set Distributions Mapped Variants
General Structure Information 3jue ACAP1 crystal structure of arfgap and ank repeat domain of acap1 2.3Å AUTH M.BAI,X.PANG,J.LOU,Q.ZHOU,K.ZHANG,J.MA,J.LI,F.SUN,V.W.HSUTITL MECHANISTIC INSIGHTS INTO REGULATED CARGO BINDING BY ACAP1TITL 2 PROTEINREF J.BIOL.CHEM. V. 287 28675 2012REFN ISSN 0021-9258PMID 22645133DOI 10.1074/JBC.M112.378810 Variant Set Distributions Mapped Variants
General Structure Information 1by1 ARHGEF7 dbl homology domain from beta-pix -1.0Å AUTH B.AGHAZADEH,K.ZHU,T.J.KUBISESKI,G.A.LIU,T.PAWSON,AUTH 2 Y.ZHENG,M.K.ROSENTITL STRUCTURE AND MUTAGENESIS OF THE DBL HOMOLOGYTITL 2 DOMAINREF NAT.STRUCT.BIOL. V. 5 1098 1998REFN ISSN 1072-8368PMID 9846881DOI 10.1038/4209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants