Assessment of Structural Intolerance and Durability
General Structure Information 3iez IQGAP2 crystal structure of the rasgap c-terminal (rgc) domain of iqgap2 1.5Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RASGAP C-TERMINAL (RGC)TITL 2 DOMAIN OF IQGAP2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2j3g FCN2 l-ficolin 2.5Å AUTH V.GARLATTI,N.BELLOY,L.MARTIN,M.LACROIX,AUTH 2 M.MATSUSHITA,Y.ENDO,T.FUJITA,J.C.FONTECILLA-CAMPS,AUTH 3 G.J.ARLAUD,N.M.THIELENS,C.GABORIAUDTITL STRUCTURAL INSIGHTS INTO THE INNATE IMMUNETITL 2 RECOGNITION SPECIFICITIES OF L- AND H-FICOLINS.REF EMBO J. V. 26 623 2007REFN ISSN 0261-4189PMID 17215869DOI 10.1038/SJ.EMBOJ.7601500 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2j4o TAB1 structure of tab1 2.25Å AUTH S.H.CONNER,G.KULAR,M.PEGGIE,S.SHEPHERD,AUTH 2 A.W.SCHUTTELKOPF,P.COHEN,D.M.F.VAN AALTENTITL TAK1-BINDING PROTEIN 1 IS A PSEUDOPHOSPHATASE.REF BIOCHEM.J. V. 399 427 2006REFN ISSN 0264-6021PMID 16879102DOI 10.1042/BJ20061077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1joc EEA1 eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate 2.2Å AUTH J.J.DUMAS,E.MERITHEW,E.SUDHARSHAN,D.RAJAMANI,AUTH 2 S.HAYES,D.LAWE,S.CORVERA,D.G.LAMBRIGHTTITL MULTIVALENT ENDOSOME TARGETING BY HOMODIMERIC EEA1.REF MOL.CELL V. 8 947 2001REFN ISSN 1097-2765PMID 11741531DOI 10.1016/S1097-2765(01)00385-9 Variant Set Distributions Mapped Variants
General Structure Information 2rei EPHA7 kinase domain of human ephrin type-a receptor 7 (epha7) 1.6Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kkt ATXN7L3 solution structure of the sca7 domain of human ataxin-7-l3 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d7m FLNC solution structure of the 14th filamin domain from human filamin c -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yuf NAB1 solution structure of the ncd2 domain in human transcriptional repressor nab1 protein -1.0Å AUTH K.SAITO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NCD2 DOMAIN IN HUMANTITL 2 TRANSCRIPTIONAL REPRESSOR NAB1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pja TSN crystal structure of human c3po complex 3.0Å AUTH X.YE,N.HUANG,Y.LIU,Z.PAROO,C.HUERTA,P.LI,S.CHEN,Q.LIU,AUTH 2 H.ZHANGTITL STRUCTURE OF C3PO AND MECHANISM OF HUMAN RISC ACTIVATION.REF NAT.STRUCT.MOL.BIOL. V. 18 650 2011REFN ISSN 1545-9993PMID 21552258DOI 10.1038/NSMB.2032 Variant Set Distributions Mapped Variants
General Structure Information 3teq STIM1 crystal structure of soar domain 1.9Å AUTH X.YANG,H.JIN,X.CAI,S.LI,Y.SHENTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO THE ACTIVATION OFTITL 2 STROMAL INTERACTION MOLECULE 1 (STIM1).REF PROC.NATL.ACAD.SCI.USA V. 109 5657 2012REFN ISSN 0027-8424PMID 22451904DOI 10.1073/PNAS.1118947109 Variant Set Distributions Mapped Variants