Assessment of Structural Intolerance and Durability
General Structure Information 2azt GNMT crystal structure of h176n mutant of human glycine n-methyltransferase 2.7Å AUTH Z.LUKA,S.PAKHOMOVA,Y.LUKA,M.E.NEWCOMER,C.WAGNERTITL DESTABILIZATION OF HUMAN GLYCINE N-METHYLTRANSFERASE BYTITL 2 H176N MUTATION.REF PROTEIN SCI. V. 16 1957 2007REFN ISSN 0961-8368PMID 17660255DOI 10.1110/PS.072921507 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wfj PPIG atomic resolution crystal structure of the ppiase domain of human cyclophilin g in complex with cyclosporin a. 0.75Å AUTH C.M.STEGMANN,D.SEELIGER,G.M.SHELDRICK,B.L.DE GROOT,M.C.WAHLTITL THE THERMODYNAMIC INFLUENCE OF TRAPPED WATER MOLECULES ON ATITL 2 PROTEIN-LIGAND INTERACTION.REF ANGEW.CHEM.INT.ED.ENGL. V. 48 5207 2009REFN ISSN 1433-7851PMID 19499554DOI 10.1002/ANIE.200900481 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3i4u DHX8 crystal structure analysis of a helicase associated domain 2.1Å AUTH D.KUDLINZKI,A.SCHMITT,H.CHRISTIAN,R.FICNERTITL STRUCTURAL ANALYSIS OF THE C-TERMINAL DOMAIN OF THETITL 2 SPLICEOSOMAL HELICASE PRP22REF BIOL.CHEM. V. 393 1131 2012REFN ISSN 1431-6730PMID 23096351DOI 10.1515/HSZ-2012-0158 Variant Set Distributions Mapped Variants
General Structure Information 2qms GRB7 crystal structure of a signaling molecule 2.1Å AUTH C.J.PORTER,J.M.MATTHEWS,J.P.MACKAY,S.E.PURSGLOVE,AUTH 2 J.W.SCHMIDBERGER,P.J.LEEDMAN,S.C.PERO,D.N.KRAG,AUTH 3 M.C.WILCE,J.A.WILCETITL GRB7 SH2 DOMAIN STRUCTURE AND INTERACTIONS WITH ATITL 2 CYCLIC PEPTIDE INHIBITOR OF CANCER CELL MIGRATIONTITL 3 AND PROLIFERATION.REF BMC STRUCT.BIOL. V. 7 58 2007REFN ESSN 1472-6807PMID 17894853DOI 10.1186/1472-6807-7-58 Variant Set Distributions Mapped Variants
General Structure Information 2v7o CAMK2G crystal structure of human calcium-calmodulin-dependent protein kinase ii gamma 2.25Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4epu ANGPT1 ang1 fibrinogen-related domain (fred) 2.1Å AUTH C.C.YEYKAL,L.SUNDARESAN,M.MRKSICH,E.J.ADAMSTITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE ANG1TITL 2 FIBRINOGEN-RELATED DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2i99 CRYM crystal structure of human mu_crystallin at 2.6 angstrom 2.6Å AUTH Z.CHENG,L.SUN,J.HE,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN {MICRO}-CRYSTALLIN COMPLEXED WITHTITL 2 NADPHREF PROTEIN SCI. V. 16 329 2007REFN ISSN 0961-8368PMID 17242435DOI 10.1110/PS.062556907 Variant Set Distributions Mapped Variants
General Structure Information 2dll IRF4 solution structure of the irf domain of human interferon regulator factors 4 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IRF DOMAIN OF HUMANTITL 2 INTERFERON REGULATOR FACTORS 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y05 PTGR1 crystal structure of human leukotriene b4 12-hydroxydehydrogenase in complex with nadp and raloxifene 2.2Å AUTH W.W.YUE,N.SHAFQAT,T.KROJER,A.C.W.PIKE,F.VON DELFT,R.SETHI,AUTH 2 P.SAVITSKY,C.JOHANSSON,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN LEUKOTRIENE B4TITL 2 12-HYDROXYDEHYDROGENASE IN COMPLEX WITH NADP AND RALOXIFENEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kgt PTK6 solution structure of sh3 domain of ptk6 -1.0Å AUTH W.LEE,S.KOTITL THE SOLUTION STRUCTURE OF SH3 DOMAIN OF PTK6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants