Assessment of Structural Intolerance and Durability
General Structure Information 2q3h RHOU the crystal structure of rhoua in the gdp-bound state. 1.73Å AUTH C.GILEADI,X.YANG,E.PAPAGRIGORIOU,J.ELKINS,Y.ZHAO,J.BRAY,AUTH 2 O.GILEADI,C.UMEANO,E.UGOCHUKWU,J.UPPENBERG,G.BUNKOCZI,AUTH 3 F.VON DELFT,A.C.W.PIKE,C.PHILLIPS,P.SAVITSKY,O.FEDOROV,AUTH 4 A.EDWARDS,J.WEIGELT,C.H.ARROWSMITH,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF RHOUA IN THE GDP-BOUND STATE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2i7a CAPN13 domain iv of human calpain 13 1.8Å AUTH J.R.WALKER,K.NG,T.L.DAVIS,R.RAVULAPALLI,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,E.M.NEWMAN,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF HUMAN CALPAIN 13REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2da1 ZFHX3 solution structure of the first homeobox domain of at- binding transcription factor 1 (atbf1) -1.0Å AUTH S.OHNISHI,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST HOMEOBOX DOMAIN OFTITL 2 AT-BINDING TRANSCRIPTION FACTOR 1 (ATBF1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wjr SFMBT2 solution structure of the 2nd mbt domain from human kiaa1617 protein -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND MBT DOMAIN FROMTITL 2 HUMAN KIAA1617 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hdh HADH biochemical characterization and structure determination of human heart short chain l-3-hydroxyacyl coa dehydrogenase provide insight into catalytic mechanism 2.2Å AUTH J.J.BARYCKI,L.K.OBRIEN,J.M.BRATT,R.ZHANG,R.SANISHVILI,AUTH 2 A.W.STRAUSS,L.J.BANASZAKTITL BIOCHEMICAL CHARACTERIZATION AND CRYSTAL STRUCTURETITL 2 DETERMINATION OF HUMAN HEART SHORT CHAIN L-3-HYDROXYACYL-COATITL 3 DEHYDROGENASE PROVIDE INSIGHTS INTO CATALYTIC MECHANISM.REF BIOCHEMISTRY V. 38 5786 1999REFN ISSN 0006-2960PMID […]
General Structure Information 4ah6 DARS2 human mitochondrial aspartyl-trna synthetase 3.7Å AUTH E.ENNIFAR,C.FLORENTZ,A.GAUDRY,B.LORBER,A.NEUENFELDT,AUTH 2 C.SAUTER,M.SISSLERTITL THERMODYNAMIC PROPERTIES DISTINGUISH HUMAN MITOCHONDRIALTITL 2 ASPARTYL-TRNA SYNTHETASE FROM BACTERIAL HOMOLOG WITH SAMETITL 3 3D ARCHITECTUREREF NUCLEIC ACIDS RES. V. 41 2698 2013REFN ISSN 0305-1048PMID 23275545DOI 10.1093/NAR/GKS1322 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bo5 SETMAR crystal structure of methyltransferase domain of human histone-lysine n-methyltransferase setmar 1.59Å AUTH H.WU,V.V.LUNIN,H.REN,E.DOBROVETSKY,J.WEIGELT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR IN COMPLEX WITHTITL 3 ADOHCY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1khu SMAD1 smad1 crystal structure reveals the details of bmp signaling pathway 2.5Å AUTH B.Y.QIN,B.M.CHACKO,S.S.LAM,M.P.DE CAESTECKER,AUTH 2 J.J.CORREIA,K.LINTITL STRUCTURAL BASIS OF SMAD1 ACTIVATION BY RECEPTORTITL 2 KINASE PHOSPHORYLATION.REF MOL.CELL V. 8 1303 2001REFN ISSN 1097-2765PMID 11779505DOI 10.1016/S1097-2765(01)00417-8 Variant Set Distributions Mapped Variants
General Structure Information 2nt2 SSH2 crystal structure of slingshot phosphatase 2 2.1Å AUTH S.K.JUNG,D.G.JEONG,T.S.YOON,J.H.KIM,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF HUMAN SLINGSHOT PHOSPHATASE 2.REF PROTEINS V. 68 408 2007REFN ISSN 0887-3585PMID 17427953DOI 10.1002/PROT.21399 Variant Set Distributions Mapped Variants
General Structure Information 2cfy TXNRD1 crystal structure of human thioredoxin reductase 1 2.7Å AUTH J.E.DEBRECZENI,C.JOHANSSON,K.KAVANAGH,P.SAVITSKY,AUTH 2 M.SUNDSTROM,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,AUTH 3 U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants