Assessment of Structural Intolerance and Durability
General Structure Information 2afo QPCT crystal structure of human glutaminyl cyclase at ph 8.0 2.35Å AUTH K.F.HUANG,Y.L.LIU,W.J.CHENG,T.P.KO,A.H.WANGTITL CRYSTAL STRUCTURES OF HUMAN GLUTAMINYL CYCLASE, AN ENZYMETITL 2 RESPONSIBLE FOR PROTEIN N-TERMINAL PYROGLUTAMATE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 102 13117 2005REFN ISSN 0027-8424PMID 16135565DOI 10.1073/PNAS.0504184102 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3of6 PTCRA human pre-t cell receptor crystal structure 2.8Å AUTH S.S.PANG,R.BERRY,Z.CHEN,L.KJER-NIELSEN,M.A.PERUGINI,AUTH 2 G.F.KING,C.WANG,S.H.CHEW,N.L.LA GRUTA,N.K.WILLIAMS,T.BEDDOE,AUTH 3 T.TIGANIS,N.P.COWIESON,D.I.GODFREY,A.W.PURCELL,M.C.J.WILCE,AUTH 4 J.MCCLUSKEY,J.ROSSJOHNTITL THE STRUCTURAL BASIS FOR AUTONOMOUS DIMERIZATION OF THETITL 2 PRE-T-CELL ANTIGEN RECEPTORREF NATURE V. 467 844 2010REFN ISSN 0028-0836PMID 20944746DOI 10.1038/NATURE09448 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4nj4 ALKBH5 crystal structure of human alkbh5 2.02Å AUTH W.AIK,J.S.SCOTTI,H.CHOI,L.GONG,M.DEMETRIADES,C.J.SCHOFIELD,AUTH 2 M.A.MCDONOUGHTITL STRUCTURE OF HUMAN RNA N6-METHYLADENINE DEMETHYLASE ALKBH5TITL 2 PROVIDES INSIGHTS INTO ITS MECHANISMS OF NUCLEIC ACIDTITL 3 RECOGNITION AND DEMETHYLATION.REF NUCLEIC ACIDS RES. V. 42 4741 2014REFN ISSN 0305-1048PMID 24489119DOI 10.1093/NAR/GKU085 Variant Set Distributions Mapped Variants
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1i1j MIA structure of melanoma inhibitory activity protein: a member of a new family of secreted proteins 1.39Å AUTH J.C.LOUGHEED,J.M.HOLTON,T.ALBER,J.F.BAZAN,AUTH 2 T.M.HANDELTITL STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN,TITL 2 A MEMBER OF A RECENTLY IDENTIFIED FAMILY OFTITL 3 SECRETED PROTEINS.REF PROC.NATL.ACAD.SCI.USA V. 98 5515 2001REFN ISSN 0027-8424PMID 11331761DOI 10.1073/PNAS.091601698 Variant Set Distributions […]
General Structure Information 2g59 PTPRO crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens 2.19Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3f4m TNFAIP8L2 crystal structure of tipe2 1.7Å AUTH X.ZHANG,J.WANG,C.FAN,H.LI,H.SUN,S.GONG,Y.H.CHEN,AUTH 2 Y.SHITITL CRYSTAL STRUCTURE OF TIPE2 PROVIDES INSIGHTS INTOTITL 2 IMMUNE HOMEOSTASISREF NAT.STRUCT.MOL.BIOL. V. 16 89 2009REFN ISSN 1545-9993PMID 19079267DOI 10.1038/NSMB.1522 Variant Set Distributions Mapped Variants
General Structure Information 3b9c LGALSL crystal structure of human grp crd 1.9Å AUTH D.ZHOU,H.GE,J.SUN,Y.GAO,M.TENG,L.NIUTITL CRYSTAL STRUCTURE OF THE C-TERMINAL CONSERVEDTITL 2 DOMAIN OF HUMAN GRP, A GALECTIN-RELATED PROTEIN,TITL 3 REVEALS A FUNCTION MODE DIFFERENT FROM THOSE OFTITL 4 GALECTINS.REF PROTEINS V. 71 1582 2008REFN ISSN 0887-3585PMID 18320588DOI 10.1002/PROT.22003 Variant Set Distributions Mapped Variants
General Structure Information 2dwp PFKFB3 a pseudo substrate complex of 6-phosphofructo-2-kinase of pfkfb 2.7Å AUTH S.G.KIM,M.CAVALIER,M.R.EL-MAGHRABI,Y.H.LEETITL A DIRECT SUBSTRATE-SUBSTRATE INTERACTION FOUND INTITL 2 THE KINASE DOMAIN OF THE BIFUNCTIONAL ENZYME,TITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-TITL 4 BISPHOSPHATASEREF J.MOL.BIOL. V. 370 14 2007REFN ISSN 0022-2836PMID 17499765DOI 10.1016/J.JMB.2007.03.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kv5 KDM7A structure of kiaa1718, human jumonji demethylase, in complex with n-oxalylglycine 2.39Å AUTH J.R.HORTON,A.K.UPADHYAY,H.H.QI,X.ZHANG,Y.SHI,AUTH 2 X.CHENGTITL ENZYMATIC AND STRUCTURAL INSIGHTS FOR SUBSTRATETITL 2 SPECIFICITY OF A FAMILY OF JUMONJI HISTONE LYSINETITL 3 DEMETHYLASES.REF NAT.STRUCT.MOL.BIOL. V. 17 38 2010REFN ISSN 1545-9993PMID 20023638DOI 10.1038/NSMB.1753 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]