Assessment of Structural Intolerance and Durability
General Structure Information 2cqk LARP4 solution structure of the la domain of c-mpl binding protein -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE LA DOMAIN OF C-MPLTITL 2 BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4doh IL20RB il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Mapped Variants
General Structure Information 3hkv PARP10 human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide 2.1Å AUTH T.KARLBERG,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,A.KOTZSCH,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,P.SCHUTZ,AUTH 6 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 8 H.SCHULERTITL HUMAN POLY(ADP-RIBOSE) POLYMERASE 10, CATALYTICTITL 2 FRAGMENT IN COMPLEX WITH AN INHIBITORTITL 3 3-AMINOBENZAMIDEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3puf RNASEH2B crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 3d6t LRRK2 structure of the roc domain from the parkinsons disease-associated leucine-rich repeat kinase 2 reveals a dimeric gtpase 2.43Å AUTH J.DENG,P.A.LEWIS,E.GREGGIO,E.SLUCH,A.BEILINA,M.R.COOKSONTITL STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSONSTITL 2 DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REVEALS ATITL 3 DIMERIC GTPASEREF PROC.NATL.ACAD.SCI.USA V. 105 1499 2008REFN ISSN 0027-8424PMID 18230735DOI 10.1073/PNAS.0709098105 Variant Set […]
General Structure Information 3bdl SND1 crystal structure of a truncated human tudor-sn 1.9Å AUTH C.L.LI,W.Z.YANG,Y.P.CHEN,H.S.YUANTITL STRUCTURAL AND FUNCTIONAL INSIGHTS INTO HUMANTITL 2 TUDOR-SN, A KEY COMPONENT LINKING RNA INTERFERENCETITL 3 AND EDITING.REF NUCLEIC ACIDS RES. V. 36 3579 2008REFN ISSN 0305-1048PMID 18453631DOI 10.1093/NAR/GKN236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4osy ASRGL1 structure of fully-cleaved glycine-bound human l-asparaginase protein 1.91Å AUTH Y.SU,C.S.KARAMITROS,J.NOMME,T.MCSORLEY,M.KONRAD,A.LAVIETITL FREE GLYCINE ACCELERATES THE AUTOPROTEOLYTIC ACTIVATION OFTITL 2 HUMAN ASPARAGINASE.REF CHEM.BIOL. V. 20 533 2013REFN ISSN 1074-5521PMID 23601642DOI 10.1016/J.CHEMBIOL.2013.03.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1u2h SPEG x-ray structure of the n-terminally truncated human apep-1 0.96Å AUTH B.A.MANJASETTY,F.H.NIESEN,C.SCHEICH,Y.ROSKE,F.GOTZ,AUTH 2 J.BEHLKE,V.SIEVERT,U.HEINEMANN,K.BUSSOWTITL X-RAY STRUCTURE OF ENGINEERED HUMAN AORTICTITL 2 PREFERENTIALLY EXPRESSED PROTEIN-1 (APEG-1)REF BMC STRUCT.BIOL. V. 5 21 2005REFN ESSN 1472-6807PMID 16354304DOI 10.1186/1472-6807-5-21 Variant Set Distributions Mapped Variants
General Structure Information 4dlj MAPK14 human p38 map kinase in complex with rl163 2.6Å AUTH M.GETLIK,J.R.SIMARD,M.TERMATHE,C.GRUTTER,M.RABILLER,AUTH 2 W.A.VAN OTTERLO,D.RAUHTITL FLUOROPHORE LABELED KINASE DETECTS LIGANDS THAT BIND WITHINTITL 2 THE MAPK INSERT OF P38ALPHA KINASE.REF PLOS ONE V. 7 39713 2012REFN ESSN 1932-6203PMID 22768308DOI 10.1371/JOURNAL.PONE.0039713 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4gwm MEP1B crystal structure of human promeprin beta 1.85Å AUTH J.L.AROLAS,C.BRODER,T.JEFFERSON,T.GUEVARA,E.E.STERCHI,AUTH 2 W.BODE,W.STOCKER,C.BECKER-PAULY,F.X.GOMIS-RUTHTITL STRUCTURAL BASIS FOR THE SHEDDASE FUNCTION OF HUMAN MEPRINTITL 2 BETA METALLOPROTEINASE AT THE PLASMA MEMBRANEREF PROC.NATL.ACAD.SCI.USA V. 109 16131 2012REFN ISSN 0027-8424PMID 22988105DOI 10.1073/PNAS.1211076109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants