Assessment of Structural Intolerance and Durability
General Structure Information 1hy9 CARTPT cocaine and amphetamine regulated transcript -1.0Å AUTH S.LUDVIGSEN,L.THIM,A.M.BLOM,B.S.WULFFTITL SOLUTION STRUCTURE OF THE SATIETY FACTOR, CART,TITL 2 REVEALS NEW FUNCTIONALITY OF A WELL-KNOWN FOLD.REF BIOCHEMISTRY V. 40 9082 2001REFN ISSN 0006-2960PMID 11478874DOI 10.1021/BI010433U Variant Set Distributions Mapped Variants
General Structure Information 1wig ABLIM2 solution structure of rsgi ruh-019, a lim domain of actin binding lim protein 2 (kiaa1808 protein) from human cdna -1.0Å AUTH T.ABE,H.HIROTA,S.KOSHIBA,T.KIGAWA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-019, A LIM DOMAINTITL 2 OF ACTIN BINDING LIM PROTEIN 2 (KIAA1808 PROTEIN)TITL 3 FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 1×68 FHL5 solution structures of the c-terminal lim domain of human fhl5 protein -1.0Å AUTH N.NAMEKI,A.SASAGAWA,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C-TERMINAL LIM DOMAINTITL 2 OF HUMAN FHL5 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2e5s MBNL2 solution structure of the zf-ccchx2 domain of muscleblind- like 2, isoform 1 [homo sapiens] -1.0Å AUTH F.HE,W.DANG,C.ABE,K.TSUDA,M.INOUE,S.WATANABE,AUTH 2 N.KOBAYASHI,T.KIGAWA,T.MATSUDA,T.YABUKI,M.AOKI,AUTH 3 E.SEKI,T.HARADA,Y.TOMABECHI,T.TERADA,M.SHIROUZU,AUTH 4 A.TANAKA,P.GUNTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN INTITL 2 THE HUMAN MUSCLEBLIND-LIKE PROTEIN 2REF PROTEIN SCI. V. 18 80 2009REFN ISSN 0961-8368PMID 19177353DOI 10.1002/PRO.17 Variant Set Distributions […]
General Structure Information 3dai ATAD2 crystal structure of the bromodomain of the human atad2 1.95Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4b87 DCLRE1A crystal structure of human dna cross-link repair 1a 2.16Å AUTH C.K.ALLERSTON,G.BERRIDGE,E.P.CARPENTER,G.KOCHAN,T.KROJER,AUTH 2 P.MAHAJAN,M.VOLLMAR,W.W.YUE,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n1q CDON crystal structure of dhhn bound to cdofn3 2.89Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 4flb RPRD2 cid of human rprd2 1.8Å AUTH Z.NI,C.XU,X.GUO,G.O.HUNTER,O.V.KUZNETSOVA,W.TEMPEL,E.MARCON,AUTH 2 G.ZHONG,H.GUO,W.H.KUO,J.LI,P.YOUNG,J.B.OLSEN,C.WAN,AUTH 3 P.LOPPNAU,M.EL BAKKOURI,G.A.SENISTERRA,H.HE,H.HUANG,AUTH 4 S.S.SIDHU,A.EMILI,S.MURPHY,A.L.MOSLEY,C.H.ARROWSMITH,J.MIN,AUTH 5 J.F.GREENBLATTTITL RPRD1A AND RPRD1B ARE HUMAN RNA POLYMERASE II C-TERMINALTITL 2 DOMAIN SCAFFOLDS FOR SER5 DEPHOSPHORYLATION.REF NAT.STRUCT.MOL.BIOL. V. 21 686 2014REFN ISSN 1545-9993PMID 24997600DOI 10.1038/NSMB.2853 Variant Set Distributions Mapped Variants
General Structure Information 2ld4 CIAPIN1 solution structure of the n-terminal domain of human anamorsin -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,F.BOSCARO,A.CHATZI,AUTH 2 M.MIKOLAJCZYK,K.TOKATLIDIS,J.WINKELMANNTITL ANAMORSIN IS A [2FE-2S] CLUSTER-CONTAINING SUBSTRATE OF THETITL 2 MIA40-DEPENDENT MITOCHONDRIAL PROTEIN TRAPPING MACHINERY.REF CHEM.BIOL. V. 18 794 2011REFN ISSN 1074-5521PMID 21700214DOI 10.1016/J.CHEMBIOL.2011.03.015 Variant Set Distributions Mapped Variants
General Structure Information 1tg6 CLPP crystallography and mutagenesis point to an essential role for the n- terminus of human mitochondrial clpp 2.1Å AUTH S.G.KANG,M.R.MAURIZI,M.THOMPSON,T.MUESER,B.AHVAZITITL CRYSTALLOGRAPHY AND MUTAGENESIS POINT TO AN ESSENTIAL ROLETITL 2 FOR THE N-TERMINUS OF HUMAN MITOCHONDRIAL CLPPREF J.STRUCT.BIOL. V. 148 338 2004REFN ISSN 1047-8477PMID 15522782DOI 10.1016/J.JSB.2004.07.004 Variant Set Distributions Mapped Variants