Assessment of Structural Intolerance and Durability
General Structure Information 2qgx UBE2Q1 ubiquitin-conjugating enzyme e2q 2.56Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4nn2 PHF6 protein crystal structure of human borjeson-forssman-lehmann syndrome associated protein phf6 1.47Å AUTH Z.LIU,F.LI,J.ZHANG,Y.MEI,J.WU,Y.SHITITL CRYSTAL STRUCTURE OF THE SECOND EXTENDED PHD DOMAIN OF HUMANTITL 2 PHF6 PROTEINREF J.BIOL.CHEM. 2014REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2m38 ANKS1B ptb domain of aida1 -1.0Å AUTH L.DONALDSONTITL TO BE PUBLISHEDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2x4f MYLK4 the crystal structure of the human myosin light chain kinase loc340156. 2.67Å AUTH J.R.C.MUNIZ,P.MAHAJAN,P.RELLOS,O.FEDOROV,B.SHRESTHA,J.WANG,AUTH 2 J.M.ELKINS,N.DAGA,R.COCKING,A.CHAIKUAD,T.KROJER,E.UGOCHUKWU,AUTH 3 W.YUE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 4 C.BOUNTRA,O.GILEADI,S.KNAPPTITL THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAINTITL 2 KINASE LOC340156REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2epz ZFP28 solution structure of the 4th c2h2 type zinc finger domain of zinc finger protein 28 homolog -1.0Å AUTH K.FUTAMI,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 4TH C2H2 TYPE ZINCTITL 2 FINGER DOMAIN OF ZINC FINGER PROTEIN 28 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m1x TICAM1 ticam-1 tir domain structure -1.0Å AUTH Y.ENOKIZONO,H.KUMETA,K.FUNAMI,M.HORIUCHI,J.SARMIENTO,AUTH 2 K.YAMASHITA,D.M.STANDLEY,M.MATSUMOTO,T.SEYA,F.INAGAKITITL STRUCTURES AND INTERFACE MAPPING OF THE TIRTITL 2 DOMAIN-CONTAINING ADAPTOR MOLECULES INVOLVED IN INTERFERONTITL 3 SIGNALING.REF PROC.NATL.ACAD.SCI.USA V. 110 19908 2013REFN ISSN 0027-8424PMID 24255114DOI 10.1073/PNAS.1222811110 Variant Set Distributions Mapped Variants
General Structure Information 3bd9 HS3ST5 human 3-o-sulfotransferase isoform 5 with bound pap 2.3Å AUTH D.XU,A.F.MOON,D.SONG,L.C.PEDERSEN,J.LIUTITL ENGINEERING SULFOTRANSFERASES TO MODIFY HEPARANTITL 2 SULFATE.REF NAT.CHEM.BIOL. V. 4 200 2008REFN ISSN 1552-4450PMID 18223645DOI 10.1038/NCHEMBIO.66 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ehr INADL solution structure of the sixth pdz domain of human inad- like protein -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SIXTH PDZ DOMAIN OFTITL 2 HUMAN INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xdv MINA crystal structure of the catalytic domain of flj14393 2.57Å AUTH R.CHOWDHURY,R.SEKIRNIK,N.C.BRISSETT,T.KROJER,C.-H.HO,S.S.NG,AUTH 2 I.J.CLIFTON,W.GE,N.J.KERSHAW,G.C.FOX,J.R.C.MUNIZ,M.VOLLMAR,AUTH 3 C.PHILLIPS,E.S.PILKA,K.L.KAVANAGH,F.VON DELFT,U.OPPERMANN ,AUTH 4 M.A.MCDONOUGH,A.J.DOHERTY,C.J.SCHOFIELDTITL RIBOSOMAL OXYGENASES ARE STRUCTURALLY CONSERVED FROMTITL 2 PROKARYOTES TO HUMANSREF NATURE V. 510 422 2014REFN ISSN 0028-0836PMID 24814345DOI 10.1038/NATURE13263 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3ph9 AGR3 crystal structure of the human anterior gradient protein 3 1.83Å AUTH V.D.NGUYEN,L.W.RUDDOCK,M.SALIN,R.K.WIERENGATITL CRYSTAL STRUCTURE OF THE HUMAN ANTERIOR GRADIENT PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants