Assessment of Structural Intolerance and Durability
General Structure Information 3nr1 HDDC3 a metazoan ortholog of spot hydrolyzes ppgpp and plays a role in starvation responses 1.9Å AUTH D.W.SUN,G.LEE,J.H.LEE,H.Y.KIM,H.W.RHEE,S.Y.PARK,K.J.KIM,AUTH 2 Y.KIM,B.Y.KIM,J.I.HONG,C.PARK,H.E.CHOY,J.H.KIM,Y.H.JEON,AUTH 3 J.CHUNGTITL A METAZOAN ORTHOLOG OF SPOT HYDROLYZES PPGPP AND FUNCTIONSTITL 2 IN STARVATION RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 17 1188 2010REFN ISSN 1545-9993PMID 20818390DOI 10.1038/NSMB.1906 Variant Set Distributions Mapped Variants
General Structure Information 2l2d OTUD7A solution nmr structure of human uba-like domain of otud7a_11_83, nesg target ht6304a/ocsp target otud7a_11_83/sgc-toronto -1.0Å AUTH B.WU,A.ASINAS,A.YEE,R.DOHERTY,A.LEMAK,A.GUTMANAS,AUTH 2 S.HOULISTON,A.SEMESI,C.H.ARROWSMITH,G.T.MONTELIONE,AUTH 3 S.DHE-PAGANONTITL THE AMINO-TERMINAL UBA DOMAIN OF OTUD7AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ys9 HOMEZ structure of the third homeodomain from the human homeobox and leucine zipper protein, homez -1.0Å AUTH S.OHNISHI,T.TOMIZAWA,S.KOSHIBA,T.HARADA,S.WATANABE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL STRUCTURE OF THE THIRD HOMEODOMAIN FROM THE HUMANTITL 2 HOMEOBOX AND LEUCINE ZIPPER PROTEIN, HOMEZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xvs TTC5 crystal structure of human ttc5 (strap) c-terminal ob domain 1.8Å AUTH C.J.ADAMS,A.C.PIKE,S.MANIAM,T.D.SHARPE,A.S.COUTTS,S.KNAPP,AUTH 2 N.B.LA THANGUE,A.N.BULLOCKTITL THE P53 COFACTOR STRAP EXHIBITS AN UNEXPECTED TPR MOTIF ANDTITL 2 OLIGONUCLEOTIDE-BINDING (OB)-FOLD STRUCTURE.REF PROC.NATL.ACAD.SCI.USA V. 109 3778 2012REFN ISSN 0027-8424PMID 22362889DOI 10.1073/PNAS.1113731109 Variant Set Distributions Mapped Variants
General Structure Information 4gll UXS1 crystal structure of human udp-xylose synthase. 2.5Å AUTH S.J.POLIZZI,R.M.WALSH,W.B.PEEPLES,J.M.LIM,L.WELLS,Z.A.WOODTITL HUMAN UDP-ALPHA-D-XYLOSE SYNTHASE AND ESCHERICHIA COLI ARNATITL 2 CONSERVE A CONFORMATIONAL SHUNT THAT CONTROLS WHETHER XYLOSETITL 3 OR 4-KETO-XYLOSE IS PRODUCED.REF BIOCHEMISTRY V. 51 8844 2012REFN ISSN 0006-2960PMID 23072385DOI 10.1021/BI301135B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3rq4 SUV420H2 crystal structure of suppressor of variegation 4-20 homolog 2 1.8Å AUTH H.WU,A.SIARHEYEVA,H.ZENG,R.LAM,A.DONG,X.H.WU,Y.LI,AUTH 2 M.SCHAPIRA,M.VEDADI,J.MINTITL CRYSTAL STRUCTURES OF THE HUMAN HISTONE H4K20TITL 2 METHYLTRANSFERASES SUV420H1 AND SUV420H2.REF FEBS LETT. V. 587 3859 2013REFN ISSN 0014-5793PMID 24396869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2em3 ZFP28 solution structure of the c2h2 type zinc finger (region 640- 672) of human zinc finger protein 28 homolog -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 640-672) OF HUMAN ZINC FINGER PROTEIN 28TITL 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dh1 ADAT2 crystal structure of human trna-specific adenosine-34 deaminase subunit adat2 2.8Å AUTH M.WELIN,L.TRESAUGUES,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,S.VAN DER BERG,AUTH 6 M.WISNIEWSKA,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN TRNA-SPECIFIC ADENOSINE-34TITL 2 DEAMINASE SUBUNIT ADAT2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3og4 IFNLR1 the crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group p21212 2.16Å AUTH Z.J.MIKNIS,E.MAGRACHEVA,W.LI,A.ZDANOV,S.V.KOTENKO,A.WLODAWERTITL CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN INTERFERON-LAMBDA1TITL 2 WITH ITS HIGH AFFINITY RECEPTOR INTERFERON-LAMBDAR1.REF J.MOL.BIOL. V. 404 650 2010REFN ISSN 0022-2836PMID 20934432DOI 10.1016/J.JMB.2010.09.068 Variant Set Distributions Ripley’s K […]
General Structure Information 4i7c SIAH1 siah1 mutant bound to synthetic peptide (ace)klrpv(23p)mvrpwvr 2.8Å AUTH J.L.STEBBINS,E.SANTELLI,Y.FENG,S.K.DE,A.PURVES,AUTH 2 K.MOTAMEDCHABOKI,B.WU,Z.A.RONAI,R.C.LIDDINGTON,M.PELLECCHIATITL STRUCTURE-BASED DESIGN OF COVALENT SIAH INHIBITORS.REF CHEM.BIOL. V. 20 973 2013REFN ISSN 1074-5521PMID 23891150DOI 10.1016/J.CHEMBIOL.2013.06.008 Variant Set Distributions Mapped Variants