Assessment of Structural Intolerance and Durability
General Structure Information 2aft SUMF1 formylglycine generating enzyme c336s mutant 1.66Å AUTH D.ROESER,A.PREUSSER-KUNZE,B.SCHMIDT,K.GASOW,J.G.WITTMANN,AUTH 2 T.DIERKS,K.VON FIGURA,M.G.RUDOLPHTITL A GENERAL BINDING MECHANISM FOR ALL HUMAN SULFATASES BY THETITL 2 FORMYLGLYCINE-GENERATING ENZYMEREF PROC.NATL.ACAD.SCI.USA V. 103 81 2006REFN ISSN 0027-8424PMID 16368756DOI 10.1073/PNAS.0507592102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4a35 ENOSF1 crystal structure of human mitochondrial enolase superfamily member 1 (enosf1) 1.74Å AUTH J.R.C.MUNIZ,D.S.FROESE,T.KROJER,M.VOLLMAR,P.CANNING,AUTH 2 U.OPPERMANN,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 F.VON DELFT,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ENOLASETITL 2 SUPERFAMILY MEMBER 1 (ENOSF1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v90 PDZD3 crystal structure of the 3rd pdz domain of intestine- and kidney-enriched pdz domain ikepp (pdzd3) 2.0Å AUTH J.UPPENBERG,C.GILEADI,C.PHILLIPS,J.ELKINS,G.BUNKOCZI,AUTH 2 C.COOPER,A.C.W.PIKE,E.SALAH,E.UGOCHUKWU,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,D.A.DOYLETITL CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- ANDTITL 2 KIDNEY-ENRICHED PDZ DOMAIN IKEPP ( PDZD3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yrh ZNF473 solution structure of the c2h2-type zinc finger domain (699- 729) from zinc finger protein 473 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2-TYPE ZINC FINGERTITL 2 DOMAIN (699-729) FROM ZINC FINGER PROTEIN 473REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nms CD300LF the crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells irem-1 2.6Å AUTH J.A.MARQUEZ,E.GALFRE,F.DUPEUX,D.FLOT,O.MORAN,AUTH 2 N.DIMASITITL THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAINTITL 2 OF THE INHIBITOR RECEPTOR EXPRESSED ON MYELOIDTITL 3 CELLS IREM-1.REF J.MOL.BIOL. V. 367 310 2007REFN ISSN 0022-2836PMID 17275839DOI 10.1016/J.JMB.2007.01.011 Variant Set […]
General Structure Information 3eo2 NET1 crystal structure of the rhogef domain of human neuroepithelial cell- transforming gene 1 protein 2.6Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMANTITL 2 NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ae7 THEM5 crystal structure of human them5 1.45Å AUTH E.ZHURAVLEVA,H.GUT,D.HYNX,D.MARCELLIN,C.K.E.BLECK,C.GENOUD,AUTH 2 P.CRON,J.J.KEUSCH,B.DUMMLER,M.D.ESPOSTI,B.A.HEMMINGSTITL ACYL COENZYME A THIOESTERASE THEM5/ACOT15 IS INVOLVED INTITL 2 CARDIOLIPIN REMODELING AND FATTY LIVER DEVELOPMENT.REF MOL.CELL.BIOL. V. 32 2685 2012REFN ISSN 0270-7306PMID 22586271DOI 10.1128/MCB.00312-12 Variant Set Distributions Mapped Variants
General Structure Information 4f0d PARP16 human artd15/parp16 in complex with 3-aminobenzamide 2.7Å AUTH T.KARLBERG,A.G.THORSELL,A.KALLAS,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSE TRANSFERASETITL 2 ARTD15/PARP16 REVEALS A NOVEL PUTATIVE REGULATORY DOMAIN.REF J.BIOL.CHEM. V. 287 24077 2012REFN ISSN 0021-9258PMID 22661712DOI 10.1074/JBC.M112.379289 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ii7 KLHL7 crystal structure of the kelch domain of human klhl7 1.63Å AUTH P.CANNING,C.D.COOPER,T.KROJER,J.W.MURRAY,A.C.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,AUTH 3 V.AYINAMPUDI,B.D.MARSDEN,O.GILEADI,S.KNAPP,F.VON DELFT,AUTH 4 A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 PROTEIN ASSEMBLY WITH THETITL 2 BTB-KELCH FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2db5 INADL solution structure of the first pdz domain of inad-like protein -1.0Å AUTH K.INOUE,C.KUROSAKI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST PDZ DOMAIN OFTITL 2 INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants