Assessment of Structural Intolerance and Durability
General Structure Information 4ib4 HTR2B crystal structure of the chimeric protein of 5-ht2b-bril in complex with ergotamine 2.7Å AUTH D.WACKER,C.WANG,V.KATRITCH,G.W.HAN,X.P.HUANG,E.VARDY,AUTH 2 J.D.MCCORVY,Y.JIANG,M.CHU,F.Y.SIU,W.LIU,H.E.XU,V.CHEREZOV,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL FEATURES FOR FUNCTIONAL SELECTIVITY AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 615 2013REFN ISSN 0036-8075PMID 23519215DOI 10.1126/SCIENCE.1232808 Variant Set Distributions Mapped Variants
General Structure Information 3ou5 SHMT2 human mitochondrial serine hydroxymethyltransferase 2 2.04Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL SERINETITL 2 HYDROXYMETHYLTRANSFERASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3u8z NF2 human merlin ferm domain 2.64Å AUTH S.D.YOGESHA,A.J.SHARFF,M.GIOVANNINI,G.BRICOGNE,T.IZARDTITL UNFURLING OF THE BAND 4.1, EZRIN, RADIXIN, MOESIN (FERM)TITL 2 DOMAIN OF THE MERLIN TUMOR SUPPRESSOR.REF PROTEIN SCI. V. 20 2113 2011REFN ISSN 0961-8368PMID 22012890DOI 10.1002/PRO.751 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cw6 HMGCL crystal structure of human hmg-coa lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria 2.1Å AUTH Z.FU,J.A.RUNQUIST,F.FOROUHAR,M.HUSSAIN,J.F.HUNT,AUTH 2 H.M.MIZIORKO,J.-J.P.KIMTITL CRYSTAL STRUCTURE OF HUMANTITL 2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE: INSIGHTSTITL 3 INTO CATALYSIS AND THE MOLECULAR BASIS FORTITL 4 HYDROXYMETHYLGLUTARIC ACIDURIAREF J.BIOL.CHEM. V. 281 7526 2006REFN ISSN 0021-9258PMID 16330550DOI 10.1074/JBC.M506880200 Variant […]
General Structure Information 3o96 AKT1 crystal structure of human akt1 with an allosteric inhibitor 2.7Å AUTH W.I.WU,W.C.VOEGTLI,H.L.STURGIS,F.P.DIZON,G.P.VIGERS,AUTH 2 B.J.BRANDHUBERTITL CRYSTAL STRUCTURE OF HUMAN AKT1 WITH AN ALLOSTERIC INHIBITORTITL 2 REVEALS A NEW MODE OF KINASE INHIBITION.REF PLOS ONE V. 5 12913 2010REFN ESSN 1932-6203PMID 20886116DOI 10.1371/JOURNAL.PONE.0012913 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1cp3 CASP3 crystal structure of the complex of apopain with the tetrapeptide inhibitor ace-dvad-fmc 2.3Å AUTH P.R.MITTL,S.DI MARCO,J.F.KREBS,X.BAI,D.S.KARANEWSKY,AUTH 2 J.P.PRIESTLE,K.J.TOMASELLI,M.G.GRUTTERTITL STRUCTURE OF RECOMBINANT HUMAN CPP32 IN COMPLEX WITH THETITL 2 TETRAPEPTIDE ACETYL-ASP-VAL-ALA-ASP FLUOROMETHYL KETONE.REF J.BIOL.CHEM. V. 272 6539 1997REFN ISSN 0021-9258PMID 9045680DOI 10.1074/JBC.272.10.6539 Variant Set Distributions Mapped Variants
General Structure Information 4dbu AKR1C3 crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (akr1c3) in complex with nadp+ and 3-((4 -(trifluoromethyl)phenyl) amino)benzoic acid 2.53Å AUTH M.CHEN,A.O.ADENIJI,B.M.TWENTER,J.D.WINKLER,D.W.CHRISTIANSON,AUTH 2 T.M.PENNINGTITL CRYSTAL STRUCTURES OF AKR1C3 CONTAINING ANTITL 2 N-(ARYL)AMINO-BENZOATE INHIBITOR AND A BIFUNCTIONAL AKR1C3TITL 3 INHIBITOR AND ANDROGEN RECEPTOR ANTAGONIST. THERAPEUTICTITL 4 LEADS FOR CASTRATE RESISTANT PROSTATE CANCER.REF […]
General Structure Information 1d1t ADH7 mutant of human sigma alcohol dehydrogenase with leucine at position 141 2.4Å AUTH P.T.XIE,T.D.HURLEYTITL METHIONINE-141 DIRECTLY INFLUENCES THE BINDING OFTITL 2 4-METHYLPYRAZOLE IN HUMAN SIGMA SIGMA ALCOHOL DEHYDROGENASE.REF PROTEIN SCI. V. 8 2639 1999REFN ISSN 0961-8368PMID 10631979 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1d6g CCKAR molecular complex of cholecystokinin-8 and n-terminus of the cholecystokinin a receptor by nmr spectroscopy -1.0Å AUTH M.PELLEGRINI,D.F.MIERKETITL MOLECULAR COMPLEX OF CHOLECYSTOKININ-8 ANDTITL 2 N-TERMINUS OF THE CHOLECYSTOKININ A RECEPTOR BYTITL 3 NMR SPECTROSCOPY.REF BIOCHEMISTRY V. 38 14775 1999REFN ISSN 0006-2960PMID 10555959DOI 10.1021/BI991272L Variant Set Distributions Mapped Variants
General Structure Information 1dc2 CDKN2A solution nmr structure of tumor suppressor p16ink4a, 20 structures -1.0Å AUTH C.YUAN,T.L.SELBY,J.LI,I.J.BYEON,M.D.TSAITITL TUMOR SUPPRESSOR INK4: REFINEMENT OF P16INK4ATITL 2 STRUCTURE AND DETERMINATION OF P15INK4B STRUCTURETITL 3 BY COMPARATIVE MODELING AND NMR DATA.REF PROTEIN SCI. V. 9 1120 2000REFN ISSN 0961-8368PMID 10892805 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]