Assessment of Structural Intolerance and Durability
General Structure Information 2hev TNFRSF4 crystal structure of the complex between ox40l and ox40 2.41Å AUTH D.M.COMPAAN,S.G.HYMOWITZTITL THE CRYSTAL STRUCTURE OF THE COSTIMULATORY OX40-OX40LTITL 2 COMPLEX.REF STRUCTURE V. 14 1321 2006REFN ISSN 0969-2126PMID 16905106DOI 10.1016/J.STR.2006.06.015 Variant Set Distributions Mapped Variants
General Structure Information 2ed9 DCC solution structure of the third fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lcr ACVRL1 nmr structure of alk1 extracellular domain -1.0Å AUTH P.MAHLAWAT,U.ILANGOVAN,A.HINCKTITL NMR SOLUTION STRUCTURE OF ALK1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2×36 LONP1 structure of the proteolytic domain of the human mitochondrial lon protease 2.0Å AUTH J.GARCIA-NAFRIA,G.ONDROVICOVA,E.BLAGOVA,AUTH 2 V.M.LEVDIKOV,J.A.BAUER,C.K.SUZUKI,E.KUTEJOVA,AUTH 3 A.J.WILKINSON,K.S.WILSONTITL STRUCTURE OF THE CATALYTIC DOMAIN OF THE HUMANTITL 2 MITOCHONDRIAL LON PROTEASE: PROPOSED RELATION OFTITL 3 OLIGOMER FORMATION AND ACTIVITY.REF PROTEIN SCI. V. 19 987 2010REFN ISSN 0961-8368PMID 20222013DOI 10.1002/PRO.376 Variant Set […]
General Structure Information 3ml5 CA7 crystal structure of the c183s/c217s mutant of human ca vii in complex with acetazolamide 2.05Å AUTH A.DI FIORE,E.TRUPPO,C.T.SUPURAN,V.ALTERIO,N.DATHAN,AUTH 2 F.BOOTORABI,S.PARKKILA,S.M.MONTI,G.DE SIMONETITL CRYSTAL STRUCTURE OF THE C183S/C217S MUTANT OF HUMAN CA VIITITL 2 IN COMPLEX WITH ACETAZOLAMIDEREF BIOORG.MED.CHEM.LETT. V. 20 5023 2010REFN ISSN 0960-894XPMID 20688517DOI 10.1016/J.BMCL.2010.07.051 Variant Set Distributions Mapped Variants
General Structure Information 3dof ARL2 complex of arl2 and bart, crystal form 2 3.3Å AUTH T.ZHANG,S.LI,Y.ZHANG,C.ZHONG,Z.LAI,J.DINGTITL CRYSTAL STRUCTURE OF THE ARL2-GTP-BART COMPLEXTITL 2 REVEALS A NOVEL RECOGNITION AND BINDING MODE OFTITL 3 SMALL GTPASE WITH EFFECTORREF STRUCTURE V. 17 602 2009REFN ISSN 0969-2126PMID 19368893DOI 10.1016/J.STR.2009.01.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1ej5 WAS solution structure of the autoinhibited conformation of wasp -1.0Å AUTH A.S.KIM,L.T.KAKALIS,N.ABDUL-MANAN,G.A.LIU,M.K.ROSENTITL AUTOINHIBITION AND ACTIVATION MECHANISMS OF THETITL 2 WISKOTT-ALDRICH SYNDROME PROTEIN.REF NATURE V. 404 151 2000REFN ISSN 0028-0836PMID 10724160DOI 10.1038/35010088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3cog CTH crystal structure of human cystathionase (cystathionine gamma lyase) in complex with dl-propargylglycine 2.0Å AUTH Q.SUN,R.COLLINS,S.HUANG,L.HOLMBERG-SCHIAVONE,G.S.ANAND,AUTH 2 C.H.TAN,S.VAN-DEN-BERG,L.W.DENG,P.K.MOORE,T.KARLBERG,AUTH 3 J.SIVARAMANTITL STRUCTURAL BASIS FOR THE INHIBITION MECHANISM OF HUMANTITL 2 CYSTATHIONINE GAMMA-LYASE, AN ENZYME RESPONSIBLE FOR THETITL 3 PRODUCTION OF H(2)S.REF J.BIOL.CHEM. V. 284 3076 2009REFN ISSN 0021-9258PMID 19019829DOI 10.1074/JBC.M805459200 Variant Set […]
General Structure Information 2yvq CPS1 crystal structure of mgs domain of carbamoyl-phosphate synthetase from homo sapiens 1.98Å AUTH Y.XIE,IHSANAWATI,S.KISHISHITA,K.MURAYAMA,AUTH 2 C.TAKEMOTO,M.SHIROZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF MGS DOMAIN OFTITL 2 CARBAMOYL-PHOSPHATE SYNTHETASE FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fxm PPM1A crystal structure of human protein phosphatase 1a (ppm1a) bound with citrate at 10 mm of mn2+ 2.5Å AUTH T.HU,L.WANG,K.WANG,J.CHEN,H.JIANG,X.SHENTITL STRUCTURAL BASIS FOR THE MN2+-DEPENDENT ACTIVATIONTITL 2 OF HUMAN PPM1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants