Assessment of Structural Intolerance and Durability
General Structure Information 2dks CEACAM8 solution structure of the first ig-like domain of human carcinoembryonic antigen related cell adhesion molecule 8 -1.0Å AUTH K.NAGASHIMA,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST IG-LIKE DOMAIN OFTITL 2 HUMAN CARCINOEMBRYONIC ANTIGEN RELATED CELLTITL 3 ADHESION MOLECULE 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1s9i MAP2K2 x-ray structure of the human mitogen-activated protein kinase kinase 2 (mek2)in a complex with ligand and mgatp 3.2Å AUTH J.F.OHREN,H.CHEN,A.PAVLOVSKY,C.WHITEHEAD,E.ZHANG,AUTH 2 P.KUFFA,C.YAN,P.MCCONNELL,C.SPESSARD,C.BANOTAI,AUTH 3 W.T.MUELLER,A.DELANEY,C.OMER,J.SEBOLT-LEOPOLD,AUTH 4 D.T.DUDLEY,I.K.LEUNG,C.FLAMME,J.WARMUS,M.KAUFMAN,AUTH 5 S.BARRETT,H.TECLE,C.A.HASEMANNTITL STRUCTURES OF HUMAN MAP KINASE KINASE 1 (MEK1) ANDTITL 2 MEK2 DESCRIBE NOVEL NONCOMPETITIVE KINASETITL 3 INHIBITION.REF NAT.STRUCT.MOL.BIOL. V. 11 1192 2004REFN […]
General Structure Information 1ncn CD86 the receptor-binding domain of human b7-2 2.7Å AUTH X.ZHANG,J.D.SCHWARTZ,S.C.ALMO,S.G.NATHENSONTITL CRYSTAL STRUCTURE OF THE RECEPTOR-BINDING DOMAINTITL 2 OF HUMAN B7-2: INSIGHTS INTO ORGANIZATION ANDTITL 3 SIGNALINGREF PROC.NATL.ACAD.SCI.USA V. 100 2586 2003REFN ISSN 0027-8424PMID 12606712DOI 10.1073/PNAS.252771499 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4imn PTGDS crystal structure of wild type human lipocalin pgds bound with peg mme 2000 2.09Å AUTH S.M.LIM,D.CHEN,H.TEO,A.ROOS,A.E.JANSSON,T.NYMAN,AUTH 2 L.TRESAUGUES,K.PERVUSHIN,P.NORDLUNDTITL STRUCTURAL AND DYNAMIC INSIGHTS INTO SUBSTRATE BINDING ANDTITL 2 CATALYSIS OF HUMAN LIPOCALIN PROSTAGLANDIN D SYNTHASE.REF J.LIPID RES. V. 54 1630 2013REFN ISSN 0022-2275PMID 23526831DOI 10.1194/JLR.M035410 Variant Set Distributions Mapped Variants
General Structure Information 1plo TGFBR2 transforming growth factor-beta type ii receptor extracellular domain -1.0Å AUTH S.DEEP,K.P.WALKER III,Z.SHU,A.P.HINCKTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 TGF-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAINREF BIOCHEMISTRY V. 42 10126 2003REFN ISSN 0006-2960PMID 12939140DOI 10.1021/BI034366A Variant Set Distributions Mapped Variants
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1emo FBN1 nmr study of a pair of fibrillin ca2+ binding epidermal growth factor-like domains, 22 structures -1.0Å AUTH A.K.DOWNING,V.KNOTT,J.M.WERNER,C.M.CARDY,AUTH 2 I.D.CAMPBELL,P.A.HANDFORDTITL SOLUTION STRUCTURE OF A PAIR OF CALCIUM-BINDINGTITL 2 EPIDERMAL GROWTH FACTOR-LIKE DOMAINS: IMPLICATIONSTITL 3 FOR THE MARFAN SYNDROME AND OTHER GENETICTITL 4 DISORDERS.REF CELL(CAMBRIDGE,MASS.) V. 85 597 1996REFN ISSN 0092-8674PMID […]
General Structure Information 3n2z PRCP the structure of human prolylcarboxypeptidase at 2.80 angstroms resolution 2.79Å AUTH S.M.SOISSON,S.B.PATEL,P.D.ABEYWICKREMA,N.J.BRYNE,R.E.DIEHL,AUTH 2 D.L.HALL,R.E.FORD,J.C.REID,K.W.RICKERT,J.M.SHIPMAN,S.SHARMA,AUTH 3 K.J.LUMBTITL STRUCTURAL DEFINITION AND SUBSTRATE SPECIFICITY OF THE S28TITL 2 PROTEASE FAMILY: THE CRYSTAL STRUCTURE OF HUMANTITL 3 PROLYLCARBOXYPEPTIDASE.REF BMC STRUCT.BIOL. V. 10 16 2010REFN ESSN 1472-6807PMID 20540760DOI 10.1186/1472-6807-10-16 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4kzx EIF1 rabbit 40s ribosomal subunit in complex with eif1. 7.81Å AUTH I.B.LOMAKIN,T.A.STEITZTITL THE INITIATION OF MAMMALIAN PROTEIN SYNTHESIS AND MRNATITL 2 SCANNING MECHANISM.REF NATURE V. 500 307 2013REFN ISSN 0028-0836PMID 23873042DOI 10.1038/NATURE12355 Variant Set Distributions Mapped Variants
General Structure Information 3d7u CSK structural basis for the recognition of c-src by its inactivator csk 4.11Å AUTH N.M.LEVINSON,M.A.SEELIGER,P.A.COLE,J.KURIYANTITL STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITSTITL 2 INACTIVATOR CSK.REF CELL(CAMBRIDGE,MASS.) V. 134 124 2008REFN ISSN 0092-8674PMID 18614016DOI 10.1016/J.CELL.2008.05.051 Variant Set Distributions Mapped Variants