Assessment of Structural Intolerance and Durability
General Structure Information 3isq HPD crystal structure of human 4-hydroxyphenylpyruvate dioxygenase 1.75Å AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2fcb FCGR2B human fc gamma receptor iib ectodomain (cd32) 1.74Å AUTH P.SONDERMANN,R.HUBER,U.JACOBTITL CRYSTAL STRUCTURE OF THE SOLUBLE FORM OF THE HUMANTITL 2 FCGAMMA-RECEPTOR IIB: A NEW MEMBER OF THETITL 3 IMMUNOGLOBULIN SUPERFAMILY AT 1.7 A RESOLUTION.REF EMBO J. V. 18 1095 1999REFN ISSN 0261-4189PMID 10064577DOI 10.1093/EMBOJ/18.5.1095 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1v7n THPO human thrombopoietin functional domain complexed to neutralizing antibody tn1 fab 3.3Å AUTH M.D.FEESE,T.TAMADA,Y.KATO,Y.MAEDA,M.HIROSE,AUTH 2 Y.MATSUKURA,H.SHIGEMATSU,T.MUTO,A.MATSUMOTO,AUTH 3 H.WATARAI,K.OGAMI,T.TAHARA,T.KATO,H.MIYAZAKI,AUTH 4 R.KUROKITITL STRUCTURE OF THE RECEPTOR-BINDING DOMAIN OF HUMANTITL 2 THROMBOPOIETIN DETERMINED BY COMPLEXATION WITH ATITL 3 NEUTRALIZING ANTIBODY FRAGMENTREF PROC.NATL.ACAD.SCI.USA V. 101 1816 2004REFN ISSN 0027-8424PMID 14769915DOI 10.1073/PNAS.0308530100 Variant Set Distributions Mapped […]
General Structure Information 2rop ATP7B solution structure of domains 3 and 4 of human atp7b -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,A.C.ROSENZWEIG,AUTH 2 L.A.YATSUNYKTITL METAL BINDING DOMAINS 3 AND 4 OF THE WILSONTITL 2 DISEASE PROTEIN: SOLUTION STRUCTURE ANDTITL 3 INTERACTION WITH THE COPPER(I) CHAPERONE HAH1REF BIOCHEMISTRY V. 47 7423 2008REFN ISSN 0006-2960PMID 18558714DOI 10.1021/BI8004736 Variant Set Distributions Mapped […]
General Structure Information 2wa0 MAGEA4 crystal structure of the human magea4 2.3Å AUTH A.K.ROOS,C.D.O.COOPER,E.UGOCHUKWU,W.W YUE,G.BERRIDGE,AUTH 2 J.M.ELKINS,A.C.W.PIKE,J.BRAY,P.FILIPPAKOPOULOS,J.MUNIZ,AUTH 3 A.CHAIKUAD,N.BURGESS-BROWN,C.H.ARROWSMITH,J.WEIGELT,AUTH 4 A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADI,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN MAGEA4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1mx2 CDKN2C structure of f71n mutant of p18ink4c 2.25Å AUTH R.N.VENKATARAMANI,T.K.MACLACHLAN,X.CHAI,AUTH 2 W.S.EL-DEIRY,R.MARMORSTEINTITL STRUCTURE-BASED DESIGN OF P18INK4C PROTEINS WITHTITL 2 INCREASED THERMODYNAMIC STABILITY AND CELL CYCLETITL 3 INHIBITORY ACTIVITYREF J.BIOL.CHEM. V. 277 48827 2002REFN ISSN 0021-9258PMID 12370184DOI 10.1074/JBC.M208061200 Variant Set Distributions Mapped Variants
General Structure Information 2d8n RCVRN crystal structure of human recoverin at 2.2 a resolution 2.2Å AUTH S.KAMO,S.KISHISHITA,K.MURAYAMA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN RECOVERIN AT 2.2 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1ji7 ETV6 crystal structure of tel sam polymer 1.45Å AUTH C.A.KIM,M.L.PHILLIPS,W.KIM,M.GINGERY,H.H.TRAN,AUTH 2 M.A.ROBINSON,S.FAHAM,J.U.BOWIETITL POLYMERIZATION OF THE SAM DOMAIN OF TEL INTITL 2 LEUKEMOGENESIS AND TRANSCRIPTIONAL REPRESSION.REF EMBO J. V. 20 4173 2001REFN ISSN 0261-4189PMID 11483520DOI 10.1093/EMBOJ/20.15.4173 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hmn TTK crystal structure of human mps1 catalytic domain in complex with atp 2.7Å AUTH M.L.CHU,Z.LANG,L.M.CHAVAS,J.NERES,O.S.FEDOROVA,L.TABERNERO,AUTH 2 M.CHERRY,D.H.WILLIAMS,K.T.DOUGLAS,P.A.EYERSTITL BIOPHYSICAL AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF MPS1TITL 2 KINASE INHIBITOR COMPLEXES.REF BIOCHEMISTRY V. 49 1689 2010REFN ISSN 0006-2960PMID 20099905DOI 10.1021/BI901970C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1uzp FBN1 integrin binding cbegf22-tb4-cbegf33 fragment of human fibrillin-1, sm bound form cbegf23 domain only. 1.78Å AUTH S.S.J.LEE,V.KNOTT,J.JOVANOVI,K.HARLOS,J.GRIMES,AUTH 2 L.CHOULIER,H.MARDON,D.I.STUART,P.A.HANDFORDTITL STRUCTURE OF THE INTEGRIN BINDING FRAGMENT FROMTITL 2 FIBRILLIN-1 GIVES NEW INSIGHTS INTO MICROFIBRILTITL 3 ORGANIZATIONREF STRUCTURE V. 12 717 2004REFN ISSN 0969-2126PMID 15062093DOI 10.1016/J.STR.2004.02.023 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]