Assessment of Structural Intolerance and Durability
General Structure Information 2fu5 RABIF structure of rab8 in complex with mss4 2.0Å AUTH A.ITZEN,O.PYLYPENKO,R.S.GOODY,K.ALEXANDROV,A.RAKTITL NUCLEOTIDE EXCHANGE VIA LOCAL PROTEINTITL 2 UNFOLDING-STRUCTURE OF RAB8 IN COMPLEX WITH MSS4REF EMBO J. V. 25 1445 2006REFN ISSN 0261-4189PMID 16541104DOI 10.1038/SJ.EMBOJ.7601044 Variant Set Distributions Mapped Variants
General Structure Information 2coj BCAT1 crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with gabapentin 2.4Å AUTH M.GOTO,I.MIYAHARA,K.HIROTSU,M.CONWAY,N.YENNAWAR,M.M.ISLAM,AUTH 2 S.M.HUTSONTITL STRUCTURAL DETERMINANTS FOR BRANCHED-CHAIN AMINOTRANSFERASETITL 2 ISOZYME-SPECIFIC INHIBITION BY THE ANTICONVULSANT DRUGTITL 3 GABAPENTINREF J.BIOL.CHEM. V. 280 37246 2005REFN ISSN 0021-9258PMID 16141215DOI 10.1074/JBC.M506486200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2pfi CLCNKA crystal structure of the cytoplasmic domain of the human chloride channel clc-ka 1.6Å AUTH S.MARKOVIC,R.DUTZLERTITL THE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THETITL 2 CHLORIDE CHANNEL CLC-KA REVEALS A CONSERVEDTITL 3 INTERACTION INTERFACE.REF STRUCTURE V. 15 715 2007REFN ISSN 0969-2126PMID 17562318DOI 10.1016/J.STR.2007.04.013 Variant Set Distributions Mapped Variants
General Structure Information 3qmk APLP1 crystal structure of the e2 domain of aplp1 in complex with heparin hexasaccharide 2.21Å AUTH Y.XUE,S.LEE,Y.HATITL CRYSTAL STRUCTURE OF AMYLOID PRECURSOR-LIKE PROTEIN 1 ANDTITL 2 HEPARIN COMPLEX SUGGESTS A DUAL ROLE OF HEPARIN IN E2TITL 3 DIMERIZATION.REF PROC.NATL.ACAD.SCI.USA V. 108 16229 2011REFN ISSN 0027-8424PMID 21930949DOI 10.1073/PNAS.1103407108 Variant Set Distributions Ripley’s […]
General Structure Information 1x0h IQGAP1 solution structure of the carboxyl-terminal rgc domain in human iqgap1 -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CARBOXYL-TERMINAL RGCTITL 2 DOMAIN IN HUMAN IQGAP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3t1i MRE11A crystal structure of human mre11: understanding tumorigenic mutations 3.0Å AUTH Y.B.PARK,J.CHAE,Y.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN MRE11: UNDERSTANDING TUMORIGENICTITL 2 MUTATIONSREF STRUCTURE V. 19 1591 2011REFN ISSN 0969-2126PMID 22078559DOI 10.1016/J.STR.2011.09.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h11 TPMT amino-terminal truncated thiopurine s-methyltransferase complexed with s-adenosyl-l-homocysteine 1.89Å AUTH J.R.HORTON,X.CHENGTITL AMINO-TERMINAL TRUNCATED THIOPURINETITL 2 S-METHYLTRANSFERASE COMPLEXED WITHTITL 3 S-ADENOSYL-L-HOMOCYSTEINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3s9d IFNAR2 binary complex between ifna2 and ifnar2 2.0Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Mapped Variants
General Structure Information 1mzd GZMK crystal structure of human pro-granzyme k 2.9Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,E.WILHARM,AUTH 2 P.FUENTES-PRIOR,W.KLINKERT,W.BODE,D.E.JENNETITL THE 2.2-A CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYMETITL 2 K REVEALS A RIGID ZYMOGEN WITH UNUSUAL FEATURESREF J.BIOL.CHEM. V. 277 50923 2002REFN ISSN 0021-9258PMID 12384499DOI 10.1074/JBC.M207962200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4kbc CSNK1D ck1d in complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- yl}methanol inhibitor 1.98Å AUTH S.MENTE,E.ARNOLD,T.BUTLER,S.CHAKRAPANI,R.CHANDRASEKARAN,AUTH 2 K.CHERRY,K.DIRICO,A.DORAN,K.FISHER,P.GALATSIS,M.GREEN,AUTH 3 M.HAYWARD,J.HUMPHREY,J.KNAFELS,J.LI,S.LIU,M.MARCONI,AUTH 4 S.MCDONALD,J.OHREN,V.PARADIS,B.SNEED,K.WALTON,T.WAGERTITL LIGAND-PROTEIN INTERACTIONS OF SELECTIVE CASEIN KINASE 1TITL 2 DELTA INHIBITORS.REF J.MED.CHEM. V. 56 6819 2013REFN ISSN 0022-2623PMID 23919824DOI 10.1021/JM4006324 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants