Assessment of Structural Intolerance and Durability
General Structure Information 1aye CPA2 human procarboxypeptidase a2 1.8Å AUTH I.GARCIA-SAEZ,D.REVERTER,J.VENDRELL,F.X.AVILES,AUTH 2 M.COLLTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMANTITL 2 PROCARBOXYPEPTIDASE A2. DECIPHERING THE BASIS OFTITL 3 THE INHIBITION, ACTIVATION AND INTRINSIC ACTIVITYTITL 4 OF THE ZYMOGEN.REF EMBO J. V. 16 6906 1997REFN ISSN 0261-4189PMID 9384570DOI 10.1093/EMBOJ/16.23.6906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4ach GSK3B gsk3b in complex with inhibitor 2.6Å AUTH S.BERG,M.BERGH,S.HELLBERG,K.HOGDIN,Y.LO-ALFREDSSON,AUTH 2 P.SODERMAN,S.VON BERG,T.WEIGELT,M.ORMO,Y.XUE,J.TUCKER,AUTH 3 J.NEELISSEN,E.JERNING,Y.NILSSON,R.BHATTITL DISCOVERY OF NOVEL POTENT AND HIGHLY SELECTIVE GLYCOGENTITL 2 SYNTHASE KINASE-3BETA (GSK3BETA) INHIBITORS FOR ALZHEIMERSTITL 3 DISEASE: DESIGN, SYNTHESIS, AND CHARACTERIZATION OFTITL 4 PYRAZINES.REF J.MED.CHEM. V. 55 9107 2012REFN ISSN 0022-2623PMID 22489897DOI 10.1021/JM201724M Variant Set Distributions Ripley’s […]
General Structure Information 2djs EPHB1 solution structures of the fn3 domain of human ephrin type- b receptor 1 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 EPHRIN TYPE-B RECEPTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hy4 MTHFS structure of human mthfs with n5-iminium phosphate 2.79Å AUTH D.WU,Y.LI,G.SONG,C.CHENG,R.ZHANG,A.JOACHIMIAK,AUTH 2 N.SHAW,Z.-J.LIUTITL STRUCTURAL BASIS FOR THE INHIBITION OF HUMANTITL 2 5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE BYTITL 3 N10-SUBSTITUTED FOLATE ANALOGUESREF CANCER RES. V. 69 7294 2009REFN ISSN 0008-5472PMID 19738041DOI 10.1158/0008-5472.CAN-09-1927 Variant Set Distributions Mapped Variants
General Structure Information 3o8v FXR1 crystal structure of the tudor domains from fxr1 2.5Å AUTH M.A.ADAMS-CIOABA,Y.GUO,C.BIAN,M.F.AMAYA,R.LAM,G.A.WASNEY,AUTH 2 M.VEDADI,C.XU,J.MINTITL STRUCTURAL STUDIES OF THE TANDEM TUDOR DOMAINS OF FRAGILE XTITL 2 MENTAL RETARDATION RELATED PROTEINS FXR1 AND FXR2.REF PLOS ONE V. 5 E1355 2010REFN ESSN 1932-6203PMID 21072162DOI 10.1371/JOURNAL.PONE.0013559 Variant Set Distributions Mapped Variants
General Structure Information 2xcv NT5C2 crystal structure of the d52n variant of cytosolic 5- nucleotidase ii in complex with inosine monophosphate and 2,3-bisphosphoglycerate 2.3Å AUTH K.WALLDEN,P.NORDLUNDTITL STRUCTURAL BASIS FOR THE ALLOSTERIC REGULATION ANDTITL 2 SUBSTRATE RECOGNITION OF HUMAN CYTOSOLIC 5-NUCLEOTIDASE IIREF J.MOL.BIOL. V. 408 684 2011REFN ISSN 0022-2836PMID 21396942DOI 10.1016/J.JMB.2011.02.059 Variant Set Distributions Ripley’s K […]
General Structure Information 1rrp RANBP2 structure of the ran-gppnhp-ranbd1 complex 2.96Å AUTH I.R.VETTER,C.NOWAK,T.NISHIMOTO,J.KUHLMANN,AUTH 2 A.WITTINGHOFERTITL STRUCTURE OF A RAN-BINDING DOMAIN COMPLEXED WITHTITL 2 RAN BOUND TO A GTP ANALOGUE: IMPLICATIONS FORTITL 3 NUCLEAR TRANSPORT.REF NATURE V. 398 39 1999REFN ISSN 0028-0836PMID 10078529DOI 10.1038/17969 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3qs7 FLT3LG crystal structure of a human flt3 ligand-receptor ternary complex 4.3Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Mapped Variants
General Structure Information 3hlk ACOT2 crystal structure of human mitochondrial acyl-coa thioesterase (acot2) 2.1Å AUTH C.R.MANDEL,B.TWEEL,L.TONGTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ACYL-COATITL 2 THIOESTERASE (ACOT2)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 385 630 2009REFN ISSN 0006-291XPMID 19497300DOI 10.1016/J.BBRC.2009.05.122 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4aqp ATXN1 the structure of the axh domain of ataxin-1. 2.45Å AUTH C.DE CHIARA,M.REES,R.P.MENON,K.PAUWELS,C.LAWRENCE,AUTH 2 P.V.KONAREV,D.I.SVERGUN,S.R.MARTIN,Y.W.CHEN,A.PASTORETITL SELF-ASSEMBLY AND CONFORMATIONAL HETEROGENEITY OF THE AXHTITL 2 DOMAIN OF ATAXIN-1: AN UNUSUAL EXAMPLE OF A CHAMELEON FOLDREF BIOPHYS.J. V. 104 1304 2013REFN ISSN 0006-3495PMID 23528090DOI 10.1016/J.BPJ.2013.01.048 Variant Set Distributions Mapped Variants