Assessment of Structural Intolerance and Durability
General Structure Information 1srq RAP1GAP crystal structure of the rap1gap catalytic domain 2.9Å AUTH O.DAUMKE,M.WEYAND,P.P.CHAKRABARTI,I.R.VETTER,A.WITTINGHOFERTITL THE GTPASE ACTIVATING PROTEIN RAP1GAP USES A CATALYTICTITL 2 ASPARAGINEREF NATURE V. 429 197 2004REFN ISSN 0028-0836PMID 15141215DOI 10.1038/NATURE02505 Variant Set Distributions Mapped Variants
General Structure Information 3bzh UBE2E1 crystal structure of human ubiquitin-conjugating enzyme e2 e1 1.6Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2ppl PNLIPRP1 human pancreatic lipase-related protein 1 2.2Å AUTH J.R.WALKER,T.DAVIS,A.SEITOVA,C.BUTLER-COLE,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE HUMAN PANCREATIC LIPASE-RELATEDTITL 2 PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2eao EPHB1 solution structure of the c-terminal sam-domain of mouse ephrin type-b receptor 1 precursor (ec 2.7.1.112) -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL SAM-DOMAIN OFTITL 2 MOUSE EPHRIN TYPE-B RECEPTOR 1 PRECURSOR (ECTITL 3 2.7.1.112)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cjz PTPN5 crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine 1.7Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K […]
General Structure Information 1av5 HINT1 pkci-substrate analog 2.0Å AUTH C.D.LIMA,M.G.KLEIN,W.A.HENDRICKSONTITL STRUCTURE-BASED ANALYSIS OF CATALYSIS ANDTITL 2 SUBSTRATE DEFINITION IN THE HIT PROTEIN FAMILY.REF SCIENCE V. 278 286 1997REFN ISSN 0036-8075PMID 9323207DOI 10.1126/SCIENCE.278.5336.286 Variant Set Distributions Mapped Variants
General Structure Information 4iku METAP1 crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with 2-((5-chloro-6-methyl-2- (pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide 1.3Å AUTH C.KISHOR,T.ARYA,R.REDDI,X.CHEN,V.SADDANAPU,A.K.MARAPAKA,AUTH 2 R.GUMPENA,D.MA,J.O.LIU,A.ADDLAGATTATITL IDENTIFICATION, BIOCHEMICAL AND STRUCTURAL EVALUATION OFTITL 2 SPECIES-SPECIFIC INHIBITORS AGAINST TYPE I METHIONINETITL 3 AMINOPEPTIDASESREF J.MED.CHEM. V. 56 5295 2013REFN ISSN 0022-2623PMID 23767698DOI 10.1021/JM400395P Variant Set Distributions Ripley’s K […]
General Structure Information 1nvp GTF2A1 human tfiia/tbp/dna complex 2.1Å AUTH M.BLEICHENBACHER,S.TAN,T.J.RICHMONDTITL NOVEL INTERACTIONS BETWEEN THE COMPONENTS OF HUMANTITL 2 AND YEAST TFIIA/TBP/DNA COMPLEXES.REF J.MOL.BIOL. V. 332 783 2003REFN ISSN 0022-2836PMID 12972251DOI 10.1016/S0022-2836(03)00887-8 Variant Set Distributions Mapped Variants
General Structure Information 3zfx EPHB1 crystal structure of ephb1 2.5Å AUTH R.C.OVERMAN,J.E.DEBRECZENI,C.M.TRUMAN,M.S.MCALISTER,AUTH 2 T.K.ATTWOODTITL COMPLETING THE STRUCTURAL FAMILY PORTRAIT OF THE HUMAN EPHBTITL 2 TYROSINE KINASE DOMAINSREF PROTEIN SCI. V. 23 627 2014REFN ISSN 0961-8368PMID 24677421DOI 10.1002/PRO.2445 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qnk HAAO crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 1.6Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYANTHRANILATETITL 2 3,4-DIOXYGENASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants