General Structure Information
| PDB ID | 4ach |
| HGNC Gene Label(s) | GSK3B |
| Structure Name | gsk3b in complex with inhibitor |
| Resolution | 2.6Å |
| Reference | AUTH S.BERG,M.BERGH,S.HELLBERG,K.HOGDIN,Y.LO-ALFREDSSON,AUTH 2 P.SODERMAN,S.VON BERG,T.WEIGELT,M.ORMO,Y.XUE,J.TUCKER,AUTH 3 J.NEELISSEN,E.JERNING,Y.NILSSON,R.BHATTITL DISCOVERY OF NOVEL POTENT AND HIGHLY SELECTIVE GLYCOGENTITL 2 SYNTHASE KINASE-3BETA (GSK3BETA) INHIBITORS FOR ALZHEIMERSTITL 3 DISEASE: DESIGN, SYNTHESIS, AND CHARACTERIZATION OFTITL 4 PYRAZINES.REF J.MED.CHEM. V. 55 9107 2012REFN ISSN 0022-2623PMID 22489897DOI 10.1021/JM201724M |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 351 |
| Number Of SNVs | 49 |
| Number Of Permutations | 27357 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.054 |
| p-value | 0.443 |
COSMIC
| Number Of Residues | 351 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3239 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.143 |
| p-value | 0.544 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 49 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.249 |
| p-value | 0.368 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
