Assessment of Structural Intolerance and Durability
General Structure Information 2h63 BLVRA crystal structure of human biliverdin reductase a (casp target) 2.7Å AUTH K.KAVANAGH,J.ELKINS,E.UGOCHUKWU,K.GUO,E.PILKA,AUTH 2 P.LUKACIK,C.SMEE,E.PAPAGRIGORIOU,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1dt4 NOVA1 crystal structure of nova-1 kh3 k-homology rna-binding domain 2.6Å AUTH H.A.LEWIS,H.CHEN,C.EDO,R.J.BUCKANOVICH,Y.Y.YANG,AUTH 2 K.MUSUNURU,R.ZHONG,R.B.DARNELL,S.K.BURLEYTITL CRYSTAL STRUCTURES OF NOVA-1 AND NOVA-2 K-HOMOLOGYTITL 2 RNA-BINDING DOMAINS.REF STRUCTURE FOLD.DES. V. 7 191 1999REFN ISSN 0969-2126PMID 10368286DOI 10.1016/S0969-2126(99)80025-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2m3o NEDD4 structure and dynamics of a human nedd4 ww domain-enac complex -1.0Å AUTH R.BOBBY,K.MEDINI,P.NEUDECKER,T.V.LEE,M.A.BRIMBLE,AUTH 2 F.J.MCDONALD,J.S.LOTT,A.J.DINGLEYTITL STRUCTURE AND DYNAMICS OF HUMAN NEDD4-1 WW3 IN COMPLEX WITHTITL 2 THE ALPHA ENAC PY MOTIF.REF BIOCHIM.BIOPHYS.ACTA V.1834 1632 2013REFN ISSN 0006-3002PMID 23665454DOI 10.1016/J.BBAPAP.2013.04.031 Variant Set Distributions Mapped Variants
General Structure Information 2j6l ALDH7A1 structure of aminoadipate-semialdehyde dehydrogenase 1.3Å AUTH C.BROCKER,N.LASSEN,T.ESTEY,A.PAPPA,M.CANTORE,V.V.ORLOVA,AUTH 2 T.CHAVAKIS,K.L.KAVANAGH,U.OPPERMANN,V.VASILIOUTITL ALDEHYDE DEHYDROGENASE 7A1 (ALDH7A1) IS A NOVEL ENZYMETITL 2 INVOLVED IN CELLULAR DEFENSE AGAINST HYPEROSMOTIC STRESS.REF J.BIOL.CHEM. V. 285 18452 2010REFN ISSN 0021-9258PMID 20207735DOI 10.1074/JBC.M109.077925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2uxw ACADVL crystal structure of human very long chain acyl-coa dehydrogenase (acadvl) 1.45Å AUTH A.C.W.PIKE,V.HOZJAN,C.SMEE,G.BERRIDGE,N.BURGESS,E.SALAH,AUTH 2 G.BUNKOCZI,J.UPPENBERG,E.UGOCHUKWU,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN VERY LONG CHAIN ACYL- COATITL 2 DEHYDROGENASE (ACADVL)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ys2 BMX solution structure of the btk motif of human cytoplasmic tyrosine-protein kinase bmx -1.0Å AUTH H.ABE,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,M.YONEYAMA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BTK MOTIF OF HUMANTITL 2 CYTOPLASMIC TYROSINE-PROTEIN KINASE BMXREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3d4j MVD crystal structure of human mevalonate diphosphate decarboxylase 2.4Å AUTH N.E.VOYNOVA,Z.FU,K.P.BATTAILE,T.J.HERDENDORF,AUTH 2 J.J.KIM,H.M.MIZIORKOTITL HUMAN MEVALONATE DIPHOSPHATE DECARBOXYLASE:TITL 2 CHARACTERIZATION, INVESTIGATION OF THE MEVALONATETITL 3 DIPHOSPHATE BINDING SITE, AND CRYSTAL STRUCTURE.REF ARCH.BIOCHEM.BIOPHYS. V. 480 58 2008REFN ISSN 0003-9861PMID 18823933DOI 10.1016/J.ABB.2008.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2aw5 ME1 crystal structure of a human malic enzyme 2.5Å AUTH E.PAPAGRIGORIOU,G.BERRIDGE,C.SMEE,J.BRAY,AUTH 2 C.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,AUTH 3 U.OPPERMANN,O.GILEADI,F.VON DELFTTITL CRYSTAL STRUCTURE OF A HUMAN MALIC ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xbb NEDD4 nedd4 hect:ub complex 2.68Å AUTH E.MASPERO,S.MARI,E.VALENTINI,A.MUSACCHIO,A.FISH,AUTH 2 S.PASQUALATO,S.POLOTITL STRUCTURE OF THE HECT:UBIQUITIN COMPLEX AND ITS ROLE INTITL 2 UBIQUITIN CHAIN ELONGATIONREF EMBO REP. V. 12 342 2011REFN ISSN 1469-221XPMID 21399620DOI 10.1038/EMBOR.2011.21 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pdf CTSC discovery of novel cyanamide-based inhibitors of cathepsin c 1.85Å AUTH D.LAINE,M.PALOVICH,P.MCCLELAND,E.PETITJEAN,I.DELHOM,H.XIE,AUTH 2 J.DENG,G.LIN,R.DAVIS,A.JOLIT,N.NEVINS,J.VILLA,J.SCHNECKTITL DISCOVERY OF NOVEL CYANAMIDE-BASED INHIBITORS OF CATHEPSIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants