Assessment of Structural Intolerance and Durability
General Structure Information 3hfw ADPRH crystal structure of human adp-ribosylhydrolase 1 (harh1) 1.92Å AUTH F.KOCH-NOLTE,J.MUELLER-DIECKMANN,M.S.WEISS,AUTH 2 C.MUELLER-DIECKMANNTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLHYDROLASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qkh GIPR crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip 1.9Å AUTH C.PARTHIER,M.KLEINSCHMIDT,P.NEUMANN,R.RUDOLPH,AUTH 2 S.MANHART,D.SCHLENZIG,J.FANGHANEL,J.-U.RAHFELD,AUTH 3 H.-U.DEMUTH,M.T.STUBBSTITL CRYSTAL STRUCTURE OF THE INCRETIN-BOUNDTITL 2 EXTRACELLULAR DOMAIN OF A G PROTEIN-COUPLEDTITL 3 RECEPTORREF PROC.NATL.ACAD.SCI.USA V. 104 13942 2007REFN ISSN 0027-8424PMID 17715056DOI 10.1073/PNAS.0706404104 Variant Set Distributions Ripley’s […]
General Structure Information 4nie RORC crystal structure of the orphan nuclear receptor ror(gamma)t ligand- binding domain in complex with small molecule ligand 2.01Å AUTH T.YANG,L.QIAN,Y.B.CHENG,W.CAI,Y.L.MA,L.Q.YANG,Q.Q.WU,AUTH 2 L.A.ORBAND-MILLER,L.ZHOU,M.HUXDORF,W.ZHANG,J.ZHANG,AUTH 3 J.N.XIANG,S.LEUNG,Y.QIU,Z.ZHONG,J.D.ELLIOT,X.C.LIN,Y.H.WANGTITL DISCOVERY OF TERTIARY AMINE AND INDOLE DERIVATIVES AS POTENTTITL 2 ROR-GAMMA-T INVERSE AGONISTSREF ACS MED.CHEM.LETT. 2013REFN ISSN 1948-5875DOI 10.1021/ML4003875 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3hm8 HK3 crystal structure of the c-terminal hexokinase domain of human hk3 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.RABEH,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OFTITL 2 HUMAN HK3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fd5 SEPHS1 crystal structure of human selenophosphate synthetase 1 complex with ampcp 1.9Å AUTH K.T.WANG,J.WANG,L.F.LI,X.D.SUTITL CRYSTAL STRUCTURES OF CATALYTIC INTERMEDIATES OFTITL 2 HUMAN SELENOPHOSPHATE SYNTHETASE 1.REF J.MOL.BIOL. V. 390 747 2009REFN ISSN 0022-2836PMID 19477186DOI 10.1016/J.JMB.2009.05.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hlz KHK crystal structure of human ketohexokinase (casp target) 1.85Å AUTH W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN KETOHEXOKINASE (CASPTITL 2 TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hle EFNB2 structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity. 2.05Å AUTH J.E.CHRENCIK,A.BROOUN,M.L.KRAUS,M.I.RECHT,A.R.KOLATKAR,AUTH 2 G.W.HAN,J.M.SEIFERT,H.WIDMER,M.AUER,P.KUHNTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THETITL 2 EPHB4-EPHRINB2 PROTEIN-PROTEIN INTERACTION AND RECEPTORTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 281 28185 2006REFN ISSN 0021-9258PMID 16867992DOI 10.1074/JBC.M605766200 Variant Set Distributions Mapped Variants
General Structure Information 2es0 RGS6 structure of the regulator of g-protein signaling domain of rgs6 2.1Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1h7u PMS2 hpms2-atpgs 2.7Å AUTH A.GUARNE,M.S.JUNOP,W.YANGTITL STRUCTURE AND FUNCTION OF THE N-TERMINAL 40 KDA FRAGMENT OFTITL 2 HUMAN PMS2: A MONOMERIC GHL ATPASEREF EMBO J. V. 20 5521 2001REFN ISSN 0261-4189PMID 11574484DOI 10.1093/EMBOJ/20.19.5521 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4jg7 RPS6KA3 structure of rsk2 ctd bound to 3-(3-(1h-pyrrolo[2,3-b]pyridine-3- carbonyl)phenyl)-2-cyanoacrylamide 3.0Å AUTH R.M.MILLER,V.O.PAAVILAINEN,S.KRISHNAN,I.M.SERAFIMOVA,AUTH 2 J.TAUNTONTITL ELECTROPHILIC FRAGMENT-BASED DESIGN OF REVERSIBLE COVALENTTITL 2 KINASE INHIBITORS.REF J.AM.CHEM.SOC. V. 135 5298 2013REFN ISSN 0002-7863PMID 23540679DOI 10.1021/JA401221B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants