Assessment of Structural Intolerance and Durability
General Structure Information 2xns GNAI1 crystal structure of human g alpha i1 bound to a designed helical peptide derived from the goloco motif of rgs14 3.41Å AUTH D.W.SAMMOND,D.E.BOSCH,G.L.BUTTERFOSS,C.PURBECK,AUTH 2 M.MACHIUS,D.P.SIDEROVSKI,B.KUHLMANTITL COMPUTATIONAL DESIGN OF THE SEQUENCE AND STRUCTURETITL 2 OF A PROTEIN-BINDING PEPTIDE.REF J.AM.CHEM.SOC. V. 133 4190 2011REFN ISSN 0002-7863PMID 21388199DOI 10.1021/JA110296Z Variant Set Distributions Ripley’s […]
General Structure Information 3ajb PEX3 crystal structure of human pex3p in complex with n-terminal pex19p peptide 2.5Å AUTH Y.SATO,H.SHIBATA,T.NAKATSU,H.NAKANO,Y.KASHIWAYAMA,T.IMANAKA,AUTH 2 H.KATOTITL STRUCTURAL BASIS FOR DOCKING OF PEROXISOMAL MEMBRANE PROTEINTITL 2 CARRIER PEX19P ONTO ITS RECEPTOR PEX3PREF EMBO J. V. 29 4083 2010REFN ISSN 0261-4189PMID 21102411DOI 10.1038/EMBOJ.2010.293 Variant Set Distributions Mapped Variants
General Structure Information 1taz PDE1B catalytic domain of human phosphodiesterase 1b 1.77Å AUTH K.Y.J.ZHANG,G.L.CARD,Y.SUZUKI,D.R.ARTIS,D.FONG,S.GILLETTE,AUTH 2 D.HSIEH,J.NEIMAN,B.L.WEST,C.ZHANG,M.V.MILBURN,S.-H.KIM,AUTH 3 J.SCHLESSINGER,G.BOLLAGTITL A GLUTAMINE SWITCH MECHANISM FOR NUCLEOTIDE SELECTIVITY BYTITL 2 PHOSPHODIESTERASESREF MOL.CELL V. 15 279 2004REFN ISSN 1097-2765PMID 15260978DOI 10.1016/J.MOLCEL.2004.07.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xzg CLTC clathrin terminal domain complexed with pitstop 1 1.7Å AUTH L.VON KLEIST,W.STAHLSCHMIDT,H.BULUT,K.GROMOVA,D.PUCHKOV,AUTH 2 M.J.ROBERTSON,K.A.MACGREGOR,N.TOMLIN,A.PECHSTEIN,N.CHAU,AUTH 3 M.CHIRCOP,J.SAKOFF,J.P.VON KRIES,W.SAENGER,H.KRAUSSLICH,AUTH 4 O.SHUPLIAKOV,P.J.ROBINSON,A.MCCLUSKEY,V.HAUCKETITL ROLE OF THE CLATHRIN TERMINAL DOMAIN IN REGULATING COATEDTITL 2 PIT DYNAMICS REVEALED BY SMALL MOLECULE INHIBITION.REF CELL(CAMBRIDGE,MASS.) V. 146 471 2011REFN ISSN 0092-8674PMID 21816279DOI 10.1016/J.CELL.2011.06.025 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2clw UBE2D2 crystal structure of human ubiquitin-conjugating enzyme ubch5b 1.94Å AUTH R.B.DODD,R.J.READTITL STRUCTURES OF TWO HUMAN UBIQUITIN-CONJUGATINGTITL 2 ENZYMES FROM TWINNED CRYSTALSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2a5g ARF6 cholera toxin a1 subunit bound to arf6(q67l) 2.66Å AUTH C.J.ONEAL,M.G.JOBLING,R.K.HOLMES,W.G.HOLTITL STRUCTURAL BASIS FOR THE ACTIVATION OF CHOLERA TOXIN BYTITL 2 HUMAN ARF6-GTP.REF SCIENCE V. 309 1093 2005REFN ISSN 0036-8075PMID 16099990DOI 10.1126/SCIENCE.1113398 Variant Set Distributions Mapped Variants
General Structure Information 1bi8 CDK6 mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1bi8 CDKN2D mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Mapped Variants
General Structure Information 2j1k CXADR cav-2 fibre head in complex with car d1 2.3Å AUTH E.SEIRADAKE,H.LORTAT-JACOB,O.BILLET,E.J.KREMER,S.CUSACKTITL STRUCTURAL AND MUTATIONAL ANALYSIS OF HUMAN AD37 AND CANINETITL 2 ADENOVIRUS 2 FIBER HEADS IN COMPLEX WITH THE D1 DOMAIN OFTITL 3 COXSACKIE AND ADENOVIRUS RECEPTOR.REF J.BIOL.CHEM. V. 281 33704 2006REFN ISSN 0021-9258PMID 16923808DOI 10.1074/JBC.M605316200 Variant Set Distributions Mapped […]
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants