Assessment of Structural Intolerance and Durability
General Structure Information 3rk2 SNAP25 truncated snare complex 2.2Å AUTH D.KUMMEL,S.S.KRISHNAKUMAR,D.T.RADOFF,F.LI,C.G.GIRAUDO,AUTH 2 F.PINCET,J.E.ROTHMAN,K.M.REINISCHTITL COMPLEXIN CROSS-LINKS PREFUSION SNARES INTO A ZIGZAG ARRAY.REF NAT.STRUCT.MOL.BIOL. V. 18 927 2011REFN ISSN 1545-9993PMID 21785414DOI 10.1038/NSMB.2101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3v6m CASP6 inhibition of caspase-6 activity by single mutation outside the active site 2.69Å AUTH Q.CAO,X.J.WANG,C.W.LIU,D.F.LIU,L.F.LI,Y.Q.GAO,X.D.SUTITL INHIBITORY MECHANISM OF CASPASE-6 PHOSPHORYLATION REVEALEDTITL 2 BY CRYSTAL STRUCTURES, MOLECULAR DYNAMICS SIMULATIONS, ANDTITL 3 BIOCHEMICAL ASSAYSREF J.BIOL.CHEM. V. 287 15371 2012REFN ISSN 0021-9258PMID 22433863DOI 10.1074/JBC.M112.351213 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4iul EIF4G2 mif4g domain of dap5 2.3Å AUTH G.VIRGILI,F.FRANK,K.FEOKTISTOVA,M.SAWICKI,N.SONENBERG,AUTH 2 C.S.FRASER,B.NAGARTITL STRUCTURAL ANALYSIS OF THE DAP5 MIF4G DOMAIN AND ITSTITL 2 INTERACTION WITH EIF4A.REF STRUCTURE V. 21 517 2013REFN ISSN 0969-2126PMID 23478064DOI 10.1016/J.STR.2013.01.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lhm LYZ crystal structures of the apo-and holomutant human lysozymes with an introduced ca2+ binding site 1.8Å AUTH K.INAKA,R.KUROKI,M.KIKUCHI,M.MATSUSHIMATITL CRYSTAL STRUCTURES OF THE APO- AND HOLOMUTANTTITL 2 HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDINGTITL 3 SITE.REF J.BIOL.CHEM. V. 266 20666 1991REFN ISSN 0021-9258PMID 1939116 Variant Set Distributions Mapped Variants
General Structure Information 2o52 RAB4B crystal structure of human rab4b in complex with gdp 2.2Å AUTH H.ZHU,W.TEMPEL,J.WANG,Y.SHEN,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB4B IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2v55 RND3 mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure 3.7Å AUTH D.KOMANDER,R.GARG,P.T.C.WAN,A.J.RIDLEY,D.BARFORDTITL MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM ATITL 2 ROCK-I:RHOE COMPLEX STRUCTURE.REF EMBO J. V. 27 3175 2008REFN ISSN 0261-4189PMID 18946488DOI 10.1038/EMBOJ.2008.226 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2o94 HDAC4 the 97h/f mutant structure of a glutamine-rich domain from histone deacetylase 4 3.0Å AUTH L.GUO,A.HAN,D.L.BATES,J.CAO,L.CHENTITL CRYSTAL STRUCTURE OF A CONSERVED N-TERMINAL DOMAINTITL 2 OF HISTONE DEACETYLASE 4 REVEALS FUNCTIONALTITL 3 INSIGHTS INTO GLUTAMINE-RICH DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 104 4297 2007REFN ISSN 0027-8424PMID 17360518DOI 10.1073/PNAS.0608041104 Variant Set Distributions Mapped Variants
General Structure Information 2fdb FGF8 crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c 2.28Å AUTH S.K.OLSEN,J.Y.H.LI,C.BROMLEIGH,A.V.ELISEENKOVA,AUTH 2 O.A.IBRAHIMI,Z.LAO,F.ZHANG,R.J.LINHARDT,A.L.JOYNER,AUTH 3 M.MOHAMMADITITL STRUCTURAL BASIS BY WHICH ALTERNATIVE SPLICINGTITL 2 MODULATES THE ORGANIZER ACTIVITY OF FGF8 IN THETITL 3 BRAINREF GENES DEV. V. 20 185 2006REFN ISSN 0890-9369PMID 16384934DOI 10.1101/GAD.1365406 Variant Set […]
General Structure Information 2x4x BRPF1 molecular basis of histone h3k36me3 recognition by the pwwp domain of brpf1. 1.85Å AUTH A.VEZZOLI,N.BONADIES,M.D.ALLEN,S.M.V.FREUND,AUTH 2 C.M.SANTIVERI,B.KVINLAUG,B.J.P.HUNTLY,B.GOTTGENS,AUTH 3 M.BYCROFTTITL MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BYTITL 2 THE PWWP DOMAIN OF BRPF1.REF NAT.STRUCT.MOL.BIOL. V. 17 617 2010REFN ISSN 1545-9993PMID 20400950DOI 10.1038/NSMB.1797 Variant Set Distributions Mapped Variants
General Structure Information 3efh PRPS1 crystal structure of human phosphoribosyl pyrophosphate synthetase 1 2.6Å AUTH X.PENG,X.LITITL CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLTITL 2 PYROPHOSPHATE SYNTHETASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants