Assessment of Structural Intolerance and Durability
General Structure Information 2ywk RBM11 crystal structure of rrm-domain derived from human putative rna-binding protein 11 1.54Å AUTH M.KAWAZOE,C.TAKEMOTO,T.KAMINISHI,T.UCHIKUBO-KAMO,AUTH 2 A.NISHINO,S.MORITA,T.TERADA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF RRM-DOMAIN DERIVED FROM HUMANTITL 2 PUTATIVE RNA-BINDING PROTEIN 11REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1e17 FOXO4 solution structure of the dna binding domain of the human forkhead transcription factor afx (foxo4) -1.0Å AUTH J.WEIGELT,I.CLIMENT,K.DAHLMAN-WRIGHT,M.WIKSTROMTITL 1H, 13C AND 15N RESONANCE ASSIGNMENTS OF THE DNATITL 2 BINDING DOMAIN OF THE HUMAN FORKHEAD TRANSCRIPTIONTITL 3 FACTOR AFXREF J.BIOMOL.NMR V. 17 181 2000REFN ISSN 0925-2738PMID 10921784DOI 10.1023/A:1008358816478 Variant Set Distributions […]
General Structure Information 2awf UBE2G1 structure of human ubiquitin-conjugating enzyme e2 g1 2.1Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4j6s YWHAG 14-3-3gamma complexed with the n-terminal sequence of tyrosine hydroxylase (residues 1-43) 3.08Å AUTH A.A.SKJEVIK,M.MILENI,A.BAUMANN,O.HALSKAU,K.TEIGEN,AUTH 2 R.C.STEVENS,A.MARTINEZTITL THE N-TERMINAL SEQUENCE OF TYROSINE HYDROXYLASE IS ATITL 2 CONFORMATIONALLY VERSATILE MOTIF THAT BINDS 14-3-3 PROTEINSTITL 3 AND MEMBRANES.REF J.MOL.BIOL. V. 426 150 2014REFN ISSN 0022-2836PMID 24055376DOI 10.1016/J.JMB.2013.09.012 Variant Set Distributions Mapped Variants
General Structure Information 1ggl RBP5 human cellular retinol binding protein iii 2.31Å AUTH C.FOLLI,V.CALDERONE,S.OTTONELLO,A.BOLCHI,G.ZANOTTI,AUTH 2 M.STOPPINI,R.BERNITITL IDENTIFICATION, RETINOID BINDING, AND X-RAYTITL 2 ANALYSIS OF A HUMAN RETINOL-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 98 3710 2001REFN ISSN 0027-8424PMID 11274389DOI 10.1073/PNAS.061455898 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1tzn ANTXR2 crystal structure of the anthrax toxin protective antigen heptameric prepore bound to the vwa domain of cmg2, an anthrax toxin receptor 4.3Å AUTH D.B.LACY,D.J.WIGELSWORTH,R.A.MELNYK,S.C.HARRISON,R.J.COLLIERTITL STRUCTURE OF HEPTAMERIC PROTECTIVE ANTIGEN BOUND TO ANTITL 2 ANTHRAX TOXIN RECEPTOR: A ROLE FOR RECEPTOR IN PH-DEPENDENTTITL 3 PORE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 101 13147 2004REFN […]
General Structure Information 3phw RPS27A otu domain of crimean congo hemorrhagic fever virus in complex with ubiquitin 2.0Å AUTH M.AKUTSU,Y.YE,S.VIRDEE,J.W.CHIN,D.KOMANDERTITL MOLECULAR BASIS FOR UBIQUITIN AND ISG15 CROSS-REACTIVITY INTITL 2 VIRAL OVARIAN TUMOR DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 2228 2011REFN ISSN 0027-8424PMID 21266548DOI 10.1073/PNAS.1015287108 Variant Set Distributions Mapped Variants
General Structure Information 3mbg GFER crystal structure of human augmenter of liver regeneration (alr) 1.85Å AUTH V.N.DAITHANKAR,S.A.SCHAEFER,M.DONG,B.J.BAHNSON,C.THORPETITL STRUCTURE OF THE HUMAN SULFHYDRYL OXIDASE AUGMENTER OF LIVERTITL 2 REGENERATION AND CHARACTERIZATION OF A HUMAN MUTATIONTITL 3 CAUSING AN AUTOSOMAL RECESSIVE MYOPATHY .REF BIOCHEMISTRY V. 49 6737 2010REFN ISSN 0006-2960PMID 20593814DOI 10.1021/BI100912M Variant Set Distributions Mapped Variants
General Structure Information 2ctl HDLBP solution structure of the 13th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 13TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dax RWDD2B solution structure of the rwd domain of human protein c21orf6 -1.0Å AUTH M.YONEYAMA,T.KIGAWA,K.SAITO,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RWD DOMAIN OF HUMANTITL 2 PROTEIN C21ORF6REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants