Assessment of Structural Intolerance and Durability
General Structure Information 2ee6 FLNB solution structure of the 21th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 21TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4jih AKR1B10 crystal structure of akr1b10 complexed with nadp+ and epalrestat 2.3Å AUTH L.ZHANG,H.ZHANG,Y.ZHAO,Z.LI,S.CHEN,J.ZHAI,Y.CHEN,W.XIE,AUTH 2 Z.WANG,Q.LI,X.ZHENG,X.HUTITL INHIBITOR SELECTIVITY BETWEEN ALDO-KETO REDUCTASETITL 2 SUPERFAMILY MEMBERS AKR1B10 AND AKR1B1: ROLE OF TRP112TITL 3 (TRP111).REF FEBS LETT. V. 587 3681 2013REFN ISSN 0014-5793PMID 24100137DOI 10.1016/J.FEBSLET.2013.09.031 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ct3 SORBS3 solution structure of the sh3 domain of the vinexin protein -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THETITL 2 VINEXIN PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cpm SPAG7 solution structure of the r3h domain of human sperm- associated antigen 7 -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE R3H DOMAIN OF HUMANTITL 2 SPERM-ASSOCIATED ANTIGEN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2v1n KIN solution structure of the region 51-160 of human kin17 reveals a winged helix fold -1.0Å AUTH L.CARLIER,A.LE MAIRE,M.GONDRY,L.GUILHAUDIS,AUTH 2 I.MILAZZO,D.DAVOUST,J.COUPRIE,B.GILQUIN,AUTH 3 S.ZINN-JUSTINTITL SOLUTION STRUCTURE OF THE REGION 51-160 OF HUMANTITL 2 KIN17 REVEALS AN ATYPICAL WINGED HELIX DOMAINREF PROTEIN SCI. V. 16 2750 2007REFN ISSN 0961-8368PMID 18029424DOI 10.1110/PS.073079107 Variant Set […]
General Structure Information 2dmb FLNB solution structure of the 15th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 15TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2qqk NRP2 neuropilin-2 a1a2b1b2 domains in complex with a semaphorin-blocking fab 2.75Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2bw0 ALDH1L1 crystal structure of the hydrolase domain of human 10-formyltetrahydrofolate 2 dehydrogenase 1.7Å AUTH P.KURSULA,H.SCHULER,S.FLODIN,P.NILSSON-EHLE,AUTH 2 D.J.OGG,P.SAVITSKY,P.NORDLUND,P.STENMARKTITL STRUCTURES OF THE HYDROLASE DOMAIN OF HUMAN 10-TITL 2 FORMYLTETRAHYDROFOLATE DEHYDROGENASE AND ITSTITL 3 COMPLEX WITH A SUBSTRATE ANALOGUE.REF ACTA CRYSTALLOGR.,SECT.D V. 62 1294 2006REFN ISSN 0907-4449PMID 17057331DOI 10.1107/S0907444906026849 Variant Set Distributions Ripley’s K […]
General Structure Information 4fvp JAK2 crystal structure of the jak2 pseudokinase domain (apo form) 2.01Å AUTH R.M.BANDARANAYAKE,D.UNGUREANU,Y.SHAN,D.E.SHAW,AUTH 2 O.SILVENNOINEN,S.R.HUBBARDTITL CRYSTAL STRUCTURES OF THE JAK2 PSEUDOKINASE DOMAIN AND THETITL 2 PATHOGENIC MUTANT V617F.REF NAT.STRUCT.MOL.BIOL. V. 19 754 2012REFN ISSN 1545-9993PMID 22820988DOI 10.1038/NSMB.2348 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants