Assessment of Structural Intolerance and Durability
General Structure Information 3w5k SNAI1 crystal structure of snail1 and importin beta complex 2.6Å AUTH S.CHOI,E.YAMASHITA,N.YASUHARA,J.SONG,S.Y.SON,Y.H.WON,AUTH 2 H.R.HONG,Y.S.SHIN,T.SEKIMOTO,I.Y.PARK,Y.YONEDA,S.J.LEETITL STRUCTURAL BASIS FOR THE SELECTIVE NUCLEAR IMPORT OF THETITL 2 C2H2 ZINC-FINGER PROTEIN SNAIL BY IMPORTIN BETA.REF ACTA CRYSTALLOGR.,SECT.D V. 70 1050 2014REFN ISSN 0907-4449PMID 24699649DOI 10.1107/S1399004714000972 Variant Set Distributions Mapped Variants
General Structure Information 1li1 COL4A1 the 1.9-a crystal structure of the noncollagenous (nc1) domain of human placenta collagen iv shows stabilization via a novel type of covalent met-lys cross-link 1.9Å AUTH M.E.THAN,S.HENRICH,R.HUBER,A.RIES,K.MANN,K.KUHN,AUTH 2 R.TIMPL,G.P.BOURENKOV,H.D.BARTUNIK,W.BODETITL THE 1.9-A CRYSTAL STRUCTURE OF THE NONCOLLAGENOUSTITL 2 (NC1) DOMAIN OF HUMAN PLACENTA COLLAGEN IV SHOWSTITL 3 STABILIZATION VIA A NOVEL […]
General Structure Information 2b90 IL4 crystal structure of the interleukin-4 variant t13dr85a 2.1Å AUTH M.KRAICH,M.KLEIN,E.PATINO,H.HARRER,J.NICKEL,W.SEBALD,AUTH 2 T.D.MUELLERTITL A MODULAR INTERFACE OF IL-4 ALLOWS FOR SCALABLE AFFINITYTITL 2 WITHOUT AFFECTING SPECIFICITY FOR THE IL-4 RECEPTORREF BMC BIOL. V. 4 13 2006REFN ESSN 1741-7007PMID 16640778DOI 10.1186/1741-7007-4-13 Variant Set Distributions Mapped Variants
General Structure Information 2hzq APOD crystal structure of human apolipoprotein d (apod) in complex with progesterone 1.8Å AUTH A.EICHINGER,A.NASREEN,H.J.KIM,A.SKERRATITL STRUCTURAL INSIGHT INTO THE DUAL LIGANDTITL 2 SPECIFICITY AND MODE OF HIGH DENSITY LIPOPROTEINTITL 3 ASSOCIATION OF APOLIPOPROTEIN D.REF J.BIOL.CHEM. V. 282 31068 2007REFN ISSN 0021-9258PMID 17699160DOI 10.1074/JBC.M703552200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2kl7 EFEMP2 solution nmr structure of the egf-like 1 domain of human fibulin-4. northeast structural genomics target hr6275 -1.0Å AUTH P.ROSSI,Y.CHIANG,S.ANDERSON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE EGF-LIKE 1 DOMAIN OFTITL 2 HUMAN FIBULIN-4. NORTHEAST STRUCTURAL GENOMICSTITL 3 TARGET HR6275REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jg8 C1QB crystallographic structure of human c1q globular heads complexed to phosphatidyl-serine 2.05Å AUTH H.PAIDASSI,P.TACNET-DELORME,V.GARLATTI,C.DARNAULT,AUTH 2 B.GHEBREHIWET,C.GABORIAUD,G.J.ARLAUD,P.FRACHETTITL C1Q BINDS PHOSPHATIDYLSERINE AND LIKELY ACTS AS ATITL 2 MULTILIGAND-BRIDGING MOLECULE IN APOPTOTIC CELLTITL 3 RECOGNITION.REF J.IMMUNOL. V. 180 2329 2008REFN ISSN 0022-1767PMID 18250442 Variant Set Distributions Mapped Variants
General Structure Information 2ald ALDOA human muscle aldolase 2.1Å AUTH A.DALBY,Z.DAUTER,J.A.LITTLECHILDTITL CRYSTAL STRUCTURE OF HUMAN MUSCLE ALDOLASE COMPLEXED WITHTITL 2 FRUCTOSE 1,6-BISPHOSPHATE: MECHANISTIC IMPLICATIONS.REF PROTEIN SCI. V. 8 291 1999REFN ISSN 0961-8368PMID 10048322 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hml LALBA alpha_lactalbumin possesses a distinct zinc binding site 1.7Å AUTH J.REN,D.I.STUART,K.R.ACHARYATITL ALPHA-LACTALBUMIN POSSESSES A DISTINCT ZINCTITL 2 BINDING SITE.REF J.BIOL.CHEM. V. 268 19292 1993REFN ISSN 0021-9258PMID 8366079 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kro EGFR nanobody/vhh domain ega1 in complex with the extracellular region of egfr 3.05Å AUTH K.R.SCHMITZ,A.BAGCHI,R.C.ROOVERS,AUTH 2 P.M.VAN BERGEN EN HENEGOUWEN,K.M.FERGUSONTITL STRUCTURAL EVALUATION OF EGFR INHIBITION MECHANISMS FORTITL 2 NANOBODIES/VHH DOMAINS.REF STRUCTURE V. 21 1214 2013REFN ISSN 0969-2126PMID 23791944DOI 10.1016/J.STR.2013.05.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1hlc LGALS2 x-ray crystal structure of the human dimeric s-lac lectin, l-14-ii, in complex with lactose at 2.9 angstroms resolution 2.9Å AUTH Y.D.LOBSANOV,M.A.GITT,H.LEFFLER,S.H.BARONDES,AUTH 2 J.M.RINITITL X-RAY CRYSTAL STRUCTURE OF THE HUMAN DIMERIC S-LACTITL 2 LECTIN, L-14-II, IN COMPLEX WITH LACTOSE AT 2.9-ATITL 3 RESOLUTION.REF J.BIOL.CHEM. V. 268 27034 1993REFN ISSN 0021-9258PMID 8262940 […]