Assessment of Structural Intolerance and Durability
General Structure Information 2gf9 RAB3D crystal structure of human rab3d in complex with gdp 1.53Å AUTH B.HONG,J.WANG,L.SHEN,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB3D IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nzx ALDH2 human mitochondrial aldehyde dehydrogenase complexed with nad+ in the presence of low mg2+ 2.45Å AUTH S.J.PEREZ-MILLER,T.D.HURLEYTITL COENZYME ISOMERIZATION IS INTEGRAL TO CATALYSIS INTITL 2 ALDEHYDE DEHYDROGENASEREF BIOCHEMISTRY V. 42 7100 2003REFN ISSN 0006-2960PMID 12795606DOI 10.1021/BI034182W Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vwi OXSR1 structure of the osr1 kinase, a hypertension drug target 2.15Å AUTH F.VILLA,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET.REF PROTEINS V. 73 1082 2008REFN ISSN 0887-3585PMID 18831043DOI 10.1002/PROT.22238 Variant Set Distributions Mapped Variants
General Structure Information 1dgb CAT human erythrocyte catalase 2.2Å AUTH C.D.PUTNAM,A.S.ARVAI,Y.BOURNE,J.A.TAINERTITL ACTIVE AND INHIBITED HUMAN CATALASE STRUCTURES:TITL 2 LIGAND AND NADPH BINDING AND CATALYTIC MECHANISM.REF J.MOL.BIOL. V. 296 295 2000REFN ISSN 0022-2836PMID 10656833DOI 10.1006/JMBI.1999.3458 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ccz HMGCR thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 1.7Å AUTH R.W.SARVER,E.BILLS,G.BOLTON,L.D.BRATTON,AUTH 2 N.L.CASPERS,J.B.DUNBAR,M.S.HARRIS,R.H.HUTCHINGS,AUTH 3 R.M.KENNEDY,S.D.LARSEN,A.PAVLOVSKY,J.A.PFEFFERKORN,AUTH 4 G.BAINBRIDGETITL THERMODYNAMIC AND STRUCTURE GUIDED DESIGN OFTITL 2 STATIN BASED INHIBITORS OFTITL 3 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE.REF J.MED.CHEM. V. 51 3804 2008REFN ISSN 0022-2623PMID 18540668DOI 10.1021/JM7015057 Variant Set Distributions Mapped Variants
General Structure Information 3mjk PDGFA structure of a growth factor precursor 2.4Å AUTH A.H.SHIM,H.LIU,P.J.FOCIA,X.CHEN,P.C.LIN,X.HETITL STRUCTURES OF A PLATELET-DERIVED GROWTH FACTOR/PROPEPTIDETITL 2 COMPLEX AND A PLATELET-DERIVED GROWTH FACTOR/RECEPTORTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 11307 2010REFN ISSN 0027-8424PMID 20534510DOI 10.1073/PNAS.1000806107 Variant Set Distributions Mapped Variants
General Structure Information 1ggu F13A1 human factor xiii with calcium bound in the ion site 2.1Å AUTH B.A.FOX,V.C.YEE,L.C.PEDERSEN,I.LE TRONG,P.D.BISHOP,AUTH 2 R.E.STENKAMP,D.C.TELLERTITL IDENTIFICATION OF THE CALCIUM BINDING SITE AND ATITL 2 NOVEL YTTERBIUM SITE IN BLOOD COAGULATION FACTORTITL 3 XIII BY X-RAY CRYSTALLOGRAPHY.REF J.BIOL.CHEM. V. 274 4917 1999REFN ISSN 0021-9258PMID 9988734DOI 10.1074/JBC.274.8.4917 Variant Set Distributions Ripley’s […]
General Structure Information 3kci HERC2 the third rld domain of herc2 1.8Å AUTH J.R.WALKER,L.QIU,A.VESTERBERG,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE THIRD RLD DOMAIN OF HERC2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1f9p PPBP crystal structure of connective tissue activating peptide- iii(ctap-iii) complexed with polyvinylsulfonic acid 1.93Å AUTH J.YANG,T.FAULK,R.ASTER,G.VISENTIN,B.EDWARDS,AUTH 2 C.CASTORTITL STRUCTURE OF THE CXC CHEMOKINE, CONNECTIVE TISSUETITL 2 ACTIVATING PEPTIDE-III, COMPLEXED WITH THE HEPARINTITL 3 ANALOGUE, POLYVINYLSULFONIC ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2v5p IGF2 complex structure of human igf2r domains 11-13 bound to igf-ii 4.1Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,AUTH 2 R.J.GILBERT,G.VAN BOXEL,A.DENLEY,J.C.WALLACE,AUTH 3 A.B.HASSAN,B.E.FORBES,E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THETITL 2 IGF-II/IGF2R INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Mapped Variants