General Structure Information
| PDB ID | 3ccz |
| HGNC Gene Label(s) | HMGCR |
| Structure Name | thermodynamic and structure guided design of statin hmg-coa reductase inhibitors |
| Resolution | 1.7Å |
| Reference | AUTH R.W.SARVER,E.BILLS,G.BOLTON,L.D.BRATTON,AUTH 2 N.L.CASPERS,J.B.DUNBAR,M.S.HARRIS,R.H.HUTCHINGS,AUTH 3 R.M.KENNEDY,S.D.LARSEN,A.PAVLOVSKY,J.A.PFEFFERKORN,AUTH 4 G.BAINBRIDGETITL THERMODYNAMIC AND STRUCTURE GUIDED DESIGN OFTITL 2 STATIN BASED INHIBITORS OFTITL 3 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE.REF J.MED.CHEM. V. 51 3804 2008REFN ISSN 0022-2623PMID 18540668DOI 10.1021/JM7015057 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 405 |
| Number Of SNVs | 49 |
| Number Of Permutations | 44446 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.127 |
| p-value | 0.793 |