Assessment of Structural Intolerance and Durability
General Structure Information 2i96 CYB5A solution structure of the oxidized microsomal human cytochrome b5 -1.0Å AUTH M.NUNEZ-QUINTANA,G.TRUAN,C.VAN HEIJENOORTTITL SOLUTION STRUCTURE OF HUMAN CYTOCHROME B5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i6w CHEK2 structure and activation mechanism of the chk2 dna-damage checkpoint kinase 3.25Å AUTH Z.CAI,N.H.CHEHAB,N.P.PAVLETICHTITL STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA DAMAGETITL 2 CHECKPOINT KINASE.REF MOL.CELL V. 35 818 2009REFN ISSN 1097-2765PMID 19782031DOI 10.1016/J.MOLCEL.2009.09.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hw5 C3 crystal structure of the human c3a anaphylatoxin 2.25Å AUTH G.BAJIC,L.YATIME,A.KLOS,G.R.ANDERSENTITL HUMAN C3A AND C3A DESARG ANAPHYLATOXINS HAVE CONSERVEDTITL 2 STRUCTURES, IN CONTRAST TO C5A AND C5A DESARG.REF PROTEIN SCI. V. 22 204 2013REFN ISSN 0961-8368PMID 23184394DOI 10.1002/PRO.2200 Variant Set Distributions Mapped Variants
General Structure Information 2q80 GGPS1 crystal structure of human geranylgeranyl pyrophosphate synthase bound to ggpp 2.7Å AUTH K.L.KAVANAGH,J.E.DUNFORD,G.BUNKOCZI,R.G.RUSSELL,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GERANYLGERANYL PYROPHOSPHATETITL 2 SYNTHASE REVEALS A NOVEL HEXAMERIC ARRANGEMENT ANDTITL 3 INHIBITORY PRODUCT BINDINGREF J.BIOL.CHEM. V. 281 22004 2006REFN ISSN 0021-9258PMID 16698791DOI 10.1074/JBC.M602603200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3v83 TF the 2.1 angstrom crystal structure of diferric human transferrin 2.1Å AUTH N.NOINAJ,N.C.EASLEY,M.OKE,N.MIZUNO,J.GUMBART,E.BOURA,AUTH 2 A.N.STEERE,O.ZAK,P.AISEN,E.TAJKHORSHID,R.W.EVANS,AUTH 3 A.R.GORRINGE,A.B.MASON,A.C.STEVEN,S.K.BUCHANANTITL STRUCTURAL BASIS FOR IRON PIRACY BY PATHOGENIC NEISSERIA.REF NATURE V. 483 53 2012REFN ISSN 0028-0836PMID 22327295DOI 10.1038/NATURE10823 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nxt DHFR preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e-and z-isomers of a series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase 1.7Å AUTH V.CODY,J.PIRAINO,J.PACE,W.LI,A.GANGJEETITL PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRALTITL 2 MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E […]
General Structure Information 4acq A2M alpha-2 macroglobulin 4.3Å AUTH A.MARRERO,S.DUQUERROY,S.TRAPANI,T.GOULAS,T.GUEVARA,AUTH 2 G.R.ANDERSEN,J.NAVAZA,L.SOTTRUP-JENSEN,F.X.GOMIS-RUTHTITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA(2)-MACROGLOBULINTITL 2 REVEALS A UNIQUE MOLECULAR CAGE.REF ANGEW.CHEM.INT.ED.ENGL. V. 51 3340 2012REFN ISSN 1433-7851PMID 22290936DOI 10.1002/ANIE.201108015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zed ALPP alkaline phosphatase from human placenta in complex with p- nitrophenyl-phosphonate 1.57Å AUTH P.LLINAS,E.A.STURA,A.MENEZ,Z.KISS,T.STIGBRAND,J.L.MILLAN,AUTH 2 M.H.LE DUTITL STRUCTURAL STUDIES OF HUMAN PLACENTAL ALKALINE PHOSPHATASETITL 2 IN COMPLEX WITH FUNCTIONAL LIGANDS.REF J.MOL.BIOL. V. 350 441 2005REFN ISSN 0022-2836PMID 15946677DOI 10.1016/J.JMB.2005.04.068 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4jnk LDHA lactate dehydrogenase a in complex with inhibitor compound 22 1.9Å AUTH P.S.DRAGOVICH,B.P.FAUBER,L.B.CORSON,C.Z.DING,C.EIGENBROT,AUTH 2 H.GE,A.M.GIANNETTI,T.HUNSAKER,S.LABADIE,Y.LIU,S.MALEK,B.PAN,AUTH 3 D.PETERSON,K.PITTS,H.E.PURKEY,S.SIDERIS,M.ULTSCH,AUTH 4 E.VANDERPORTEN,B.WEI,Q.XU,I.YEN,Q.YUE,H.ZHANG,X.ZHANGTITL IDENTIFICATION OF SUBSTITUTEDTITL 2 2-THIO-6-OXO-1,6-DIHYDROPYRIMIDINES AS INHIBITORS OF HUMANTITL 3 LACTATE DEHYDROGENASE.REF BIOORG.MED.CHEM.LETT. V. 23 3186 2013REFN ISSN 0960-894XPMID 23628333DOI 10.1016/J.BMCL.2013.04.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2xrc CFI human complement factor i 2.69Å AUTH P.ROVERSI,S.JOHNSON,J.J.CAESAR,F.MCLEAN,K.J.LEATH,AUTH 2 S.A.TSIFTSOGLOU,B.P.MORGAN,C.L.HARRIS,R.B.SIM,S.M.LEATITL STRUCTURAL BASIS FOR COMPLEMENT FACTOR I CONTROL AND ITSTITL 2 DISEASE-ASSOCIATED SEQUENCE POLYMORPHISMS.REF PROC.NATL.ACAD.SCI.USA V. 108 12839 2011REFN ISSN 0027-8424PMID 21768352DOI 10.1073/PNAS.1102167108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants