General Structure Information
| PDB ID | 3nxt |
| HGNC Gene Label(s) | DHFR |
| Structure Name | preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e-and z-isomers of a series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase |
| Resolution | 1.7Å |
| Reference | AUTH V.CODY,J.PIRAINO,J.PACE,W.LI,A.GANGJEETITL PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRALTITL 2 MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E AND ZTITL 3 ISOMERS OF A SERIES OF 5-SUBSTITUTEDTITL 4 2,4-DIAMINOFURO[2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITHTITL 5 NADPH AND HUMAN DIHYDROFOLATE REDUCTASE.REF ACTA CRYSTALLOGR.,SECT.D V. 66 1271 2010REFN ISSN 0907-4449PMID 21123866DOI 10.1107/S0907444910035808 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 186 |
| Number Of SNVs | 25 |
| Number Of Permutations | 2439 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.03 |
| p-value | 0.82 |