Assessment of Structural Intolerance and Durability
General Structure Information 2jvn PARP1 domain c of human parp-1 -1.0Å AUTH Z.TAO,P.GAO,D.W.HOFFMAN,H.W.LIUTITL DOMAIN C OF HUMAN POLY(ADP-RIBOSE) POLYMERASE-1 IS IMPORTANTTITL 2 FOR ENZYME ACTIVITY AND CONTAINS A NOVEL ZINC-RIBBON MOTIF.REF BIOCHEMISTRY V. 47 5804 2008REFN ISSN 0006-2960PMID 18452307DOI 10.1021/BI800018A Variant Set Distributions Mapped Variants
General Structure Information 3rhk MET crystal structure of the catalytic domain of c-met kinase in complex with arq 197 1.94Å AUTH S.EATHIRAJ,R.PALMA,E.VOLCKOVA,M.HIRSCHI,D.S.FRANCE,AUTH 2 M.A.ASHWELL,T.C.CHANTITL DISCOVERY OF A NOVEL MODE OF PROTEIN KINASE INHIBITIONTITL 2 CHARACTERIZED BY THE MECHANISM OF INHIBITION OF HUMANTITL 3 MESENCHYMAL-EPITHELIAL TRANSITION FACTOR (C-MET) PROTEINTITL 4 AUTOPHOSPHORYLATION BY ARQ 197.REF J.BIOL.CHEM. V. […]
General Structure Information 1hup MBL2 human mannose binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil 2.5Å AUTH S.SHERIFF,C.Y.CHANG,R.A.EZEKOWITZTITL HUMAN MANNOSE-BINDING PROTEIN CARBOHYDRATE RECOGNITIONTITL 2 DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICALTITL 3 COILED-COIL.REF NAT.STRUCT.BIOL. V. 1 789 1994REFN ISSN 1072-8368PMID 7634089DOI 10.1038/NSB1194-789 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1u3t ADH1A crystal structure of human alcohol dehydrogenase alpha- alpha isoform complexed with n-cyclopentyl-n- cyclobutylformamide determined to 2.5 angstrom resolution 2.49Å AUTH B.J.GIBBONS,T.D.HURLEYTITL STRUCTURE OF THREE CLASS I HUMAN ALCOHOLTITL 2 DEHYDROGENASES COMPLEXED WITH ISOENZYME SPECIFICTITL 3 FORMAMIDE INHIBITORSREF BIOCHEMISTRY V. 43 12555 2004REFN ISSN 0006-2960PMID 15449945DOI 10.1021/BI0489107 Variant Set Distributions Ripley’s […]
General Structure Information 2e0m RNASE1 mutant human ribonuclease 1 (t24l, q28l, r31l, r32l) 1.7Å AUTH H.YAMADA,T.TAMADA,M.KOSAKA,K.MIYATA,S.FUJIKI,M.TANO,AUTH 2 M.MORIYA,M.YAMANISHI,E.HONJO,H.TADA,T.INO,H.YAMAGUCHI,AUTH 3 J.FUTAMI,M.SENO,T.NOMOTO,T.HIRATA,M.YOSHIMURA,R.KUROKITITL CRYSTAL LATTICE ENGINEERING, AN APPROACH TO ENGINEERTITL 2 PROTEIN CRYSTAL CONTACTS BY CREATING INTERMOLECULARTITL 3 SYMMETRY: CRYSTALLIZATION AND STRUCTURE DETERMINATION OF ATITL 4 MUTANT HUMAN RNASE 1 WITH A HYDROPHOBIC INTERFACE OFTITL 5 LEUCINESREF PROTEIN […]
General Structure Information 1irh TFPI the solution structure of the third kunitz domain of tissue factor pathway inhibitor -1.0Å AUTH S.MINE,T.YAMAZAKI,T.MIYATA,S.HARA,H.KATOTITL STRUCTURAL MECHANISM FOR HEPARIN-BINDING OF THETITL 2 THIRD KUNITZ DOMAIN OF HUMAN TISSUE FACTOR PATHWAYTITL 3 INHIBITOR.REF BIOCHEMISTRY V. 41 78 2002REFN ISSN 0006-2960PMID 11772005DOI 10.1021/BI011299G Variant Set Distributions Mapped Variants
General Structure Information 1msg CXCL1 solution structure of gro(slash)melanoma growth stimulatory activity determined by 1h nmr spectroscopy -1.0Å AUTH K.S.KIM,I.CLARK-LEWIS,B.D.SYKESTITL SOLUTION STRUCTURE OF GRO/MELANOMA GROWTHTITL 2 STIMULATORY ACTIVITY DETERMINED BY 1H NMRTITL 3 SPECTROSCOPY.REF J.BIOL.CHEM. V. 269 32909 1994REFN ISSN 0021-9258PMID 7806518 Variant Set Distributions Mapped Variants
General Structure Information 3ffn GSN crystal structure of calcium-free human gelsolin 3.0Å AUTH S.NAG,Q.MA,H.WANG,S.CHUMNARNSILPA,W.L.LEE,AUTH 2 M.LARSSON,B.KANNAN,M.HERNANDEZ-VALLADARES,AUTH 3 L.D.BURTNICK,R.C.ROBINSONTITL CA2+ BINDING BY DOMAIN 2 PLAYS A CRITICAL ROLE INTITL 2 THE ACTIVATION AND STABILIZATION OF GELSOLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13713 2009REFN ISSN 0027-8424PMID 19666512DOI 10.1073/PNAS.0812374106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2x2u RET first two cadherin-like domains from human ret 2.0Å AUTH S.KJAER,S.HANRAHAN,N.TOTTY,N.Q.MCDONALDTITL MAMMAL-RESTRICTED ELEMENTS PREDISPOSE HUMAN RET TOTITL 2 FOLDING IMPAIRMENT BY HSCR MUTATIONS.REF NAT.STRUCT.MOL.BIOL. V. 17 726 2010REFN ISSN 1545-9993PMID 20473317DOI 10.1038/NSMB.1808 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3p1m FDX1 crystal structure of human ferredoxin-1 (fdx1) in complex with iron- sulfur cluster 2.54Å AUTH A.CHAIKUAD,C.JOHANSSON,T.KROJER,W.W.YUE,C.PHILLIPS,J.E.BRAY,AUTH 2 A.C.W.PIKE,J.R.C.MUNIZ,M.VOLLMAR,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,K.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN FERREDOXIN-1 (FDX1) IN COMPLEXTITL 2 WITH IRON-SULFUR CLUSTERREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants