Assessment of Structural Intolerance and Durability
General Structure Information 1itv MMP9 dimeric form of the haemopexin domain of mmp9 1.95Å AUTH H.CHA,E.KOPETZKI,R.HUBER,M.LANZENDORFER,AUTH 2 H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE ADAPTIVE MOLECULARTITL 2 RECOGNITION BY MMP9.REF J.MOL.BIOL. V. 320 1065 2002REFN ISSN 0022-2836PMID 12126625DOI 10.1016/S0022-2836(02)00558-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y7j PHKG2 structure of human phosphorylase kinase, gamma 2 2.5Å AUTH J.R.C.MUNIZ,A.SHRESTHA,P.SAVITSKY,J.WANG,P.RELLOS,O.FEDOROV,AUTH 2 N.BURGESS-BROWN,B.BRENNER,G.BERRIDGE,J.M.ELKINS,T.KROJER,AUTH 3 M.VOLLMAR,K.H.CHE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 4 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1h66 NQO1 crystal structure of human nad[p]h-quinone oxidoreductase co with 2,5-diaziridinyl-3-hydroxyl-6-methyl-1,4-benzoquinone 2.0Å AUTH M.FAIG,M.A.BIANCHET,S.WINSKI,R.HARGREAVES,C.J.MOODY,AUTH 2 A.R.HUDNOTT,D.ROSS,L.M.AMZELTITL STRUCTURE-BASED DEVELOPMENT OF ANTICANCER DRUGS: COMPLEXESTITL 2 OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 WITH CHEMOTHERAPEUTICTITL 3 QUINONESREF STRUCTURE V. 9 659 2001REFN ISSN 0969-2126PMID 11587640DOI 10.1016/S0969-2126(01)00636-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2w2v RAC2 rac2 (g12v) in complex with gtpgs 2.0Å AUTH T.D.BUNNEY,O.OPALEYE,S.M.ROE,P.VATTER,AUTH 2 R.W.BAXENDALE,C.WALLISER,K.L.EVERETT,M.B.JOSEPHS,AUTH 3 C.CHRISTOW,F.RODRIGUES-LIMA,P.GIERSCHIK,L.H.PEARL,AUTH 4 M.KATANTITL STRUCTURAL INSIGHTS INTO FORMATION OF AN ACTIVETITL 2 SIGNALING COMPLEX BETWEEN RAC AND PHOSPHOLIPASE CTITL 3 GAMMA 2.REF MOL.CELL V. 34 223 2009REFN ISSN 1097-2765PMID 19394299DOI 10.1016/J.MOLCEL.2009.02.023 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1uwy CPM crystal structure of human carboxypeptidase m 3.0Å AUTH D.REVERTER,K.MASKOS,F.TAN,R.SKIDGEL,W.BODETITL CRYSTAL STRUCTURE OF HUMAN CARBOXYPEPTIDASE M, ATITL 2 MEMBRANE-BOUND ENZYME THAT REGULATES PEPTIDETITL 3 HORMONE ACTIVITYREF J.MOL.BIOL. V. 338 257 2004REFN ISSN 0022-2836PMID 15066430DOI 10.1016/J.JMB.2004.02.058 Variant Set Distributions Mapped Variants
General Structure Information 4bqa ETS2 crystal structure of the ets domain of human ets2 in complex with dna 2.5Å AUTH J.A.NEWMAN,C.D.O.COOPER,H.AITKENHEAD,O.GILEADITITL STRUCTURAL INSIGHTS INTO THE AUTOREGULATION ANDTITL 2 COOPERATIVITY OF THE HUMAN TRANSCRIPTION FACTOR ETS-2.REF J.BIOL.CHEM. V. 290 8539 2015REFN ISSN 0021-9258PMID 25670864DOI 10.1074/JBC.M114.619270 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2d85 LCP1 solution structure of the fourth ch domain from human l- plastin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH CH DOMAIN FROMTITL 2 HUMAN L-PLASTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1cvj PABPC1 x-ray crystal structure of the poly(a)-binding protein in complex with polyadenylate rna 2.6Å AUTH R.C.DEO,J.B.BONANNO,N.SONENBERG,S.K.BURLEYTITL RECOGNITION OF POLYADENYLATE RNA BY THETITL 2 POLY(A)-BINDING PROTEIN.REF CELL(CAMBRIDGE,MASS.) V. 98 835 1999REFN ISSN 0092-8674PMID 10499800DOI 10.1016/S0092-8674(00)81517-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qa9 CD58 structure of a heterophilic adhesion complex between the human cd2 and cd58(lfa-3) counter-receptors 3.2Å AUTH J.H.WANG,A.SMOLYAR,K.TAN,J.H.LIU,M.KIM,Z.Y.SUN,AUTH 2 G.WAGNER,E.L.REINHERZTITL STRUCTURE OF A HETEROPHILIC ADHESION COMPLEXTITL 2 BETWEEN THE HUMAN CD2 AND CD58 (LFA-3)TITL 3 COUNTERRECEPTORS.REF CELL(CAMBRIDGE,MASS.) V. 97 791 1999REFN ISSN 0092-8674PMID 10380930DOI 10.1016/S0092-8674(00)80790-4 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xsx ENO3 crystal structure of human beta enolase enob 1.7Å AUTH M.VOLLMAR,E.KRYSZTOFINSKA,A.CHAIKUAD,T.KROJER,R.COCKING,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 W.W.YUE,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA ENOLASE ENOBREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants