Assessment of Structural Intolerance and Durability
General Structure Information 1fd0 RARG isotype selectivity of the human retinoic acid nuclear receptor hrar: the complex with the rargamma-selective retinoid sr11254 1.38Å AUTH B.KLAHOLZ,D.MORASTITL C-H…O HYDROGEN BONDS IN THE NUCLEAR RECEPTORTITL 2 RARGAMMA–A POTENTIAL TOOL FOR DRUG SELECTIVITY.REF STRUCTURE V. 10 1197 2002REFN ISSN 0969-2126PMID 12220491DOI 10.1016/S0969-2126(02)00828-6 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2q7m ALOX5AP crystal structure of human flap with mk-591 4.25Å AUTH A.D.FERGUSON,B.M.MCKEEVER,S.XU,D.WISNIEWSKI,AUTH 2 D.K.MILLER,T.T.YAMIN,R.H.SPENCER,L.CHU,AUTH 3 F.UJJAINWALLA,B.R.CUNNINGHAM,J.F.EVANS,J.W.BECKERTITL CRYSTAL STRUCTURE OF INHIBITOR-BOUND HUMANTITL 2 5-LIPOXYGENASE-ACTIVATING PROTEIN.REF SCIENCE V. 317 510 2007REFN ISSN 0036-8075PMID 17600184DOI 10.1126/SCIENCE.1144346 Variant Set Distributions Mapped Variants
General Structure Information 1g13 GM2A human gm2 activator structure 2.0Å AUTH C.S.WRIGHT,S.C.LI,F.RASTINEJADTITL CRYSTAL STRUCTURE OF HUMAN GM2-ACTIVATOR PROTEINTITL 2 WITH A NOVEL BETA-CUP TOPOLOGY.REF J.MOL.BIOL. V. 304 411 2000REFN ISSN 0022-2836PMID 11090283DOI 10.1006/JMBI.2000.4225 Variant Set Distributions Mapped Variants
General Structure Information 2atx RHOQ crystal structure of the tc10 gppnhp complex 2.65Å AUTH L.HEMSATH,R.DVORSKY,D.FIEGEN,M.F.CARLIER,M.R.AHMADIANTITL AN ELECTROSTATIC STEERING MECHANISM OF CDC42 RECOGNITION BYTITL 2 WISKOTT-ALDRICH SYNDROME PROTEINSREF MOL.CELL V. 20 313 2005REFN ISSN 1097-2765PMID 16246732DOI 10.1016/J.MOLCEL.2005.08.036 Variant Set Distributions Mapped Variants
General Structure Information 3bk3 BMP2 crystal structure of the complex of bmp-2 and the first von willebrand domain type c of crossveinless-2 2.7Å AUTH J.-L.ZHANG,L.-Y.QIU,A.KOTZSCH,S.WEIDAUER,AUTH 2 L.PATTERSON,M.HAMMERSCHMIDT,W.SEBALD,T.D.MUELLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS HOW THE CHORDINTITL 2 FAMILY MEMBER CROSSVEINLESS 2 BLOCKS BMP-2TITL 3 RECEPTOR BINDINGREF DEV.CELL V. 14 739 2008REFN ISSN 1534-5807PMID 18477456DOI 10.1016/J.DEVCEL.2008.02.017 Variant Set […]
General Structure Information 2bb5 TCN2 structure of human transcobalamin in complex with cobalamin 3.2Å AUTH J.WUERGES,G.GARAU,S.GEREMIA,S.N.FEDOSOV,T.E.PETERSEN,AUTH 2 L.RANDACCIOTITL STRUCTURAL BASIS FOR MAMMALIAN VITAMIN B12 TRANSPORT BYTITL 2 TRANSCOBALAMIN.REF PROC.NATL.ACAD.SCI.USA V. 103 4386 2006REFN ISSN 0027-8424PMID 16537422DOI 10.1073/PNAS.0509099103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1rw2 XRCC5 three-dimensional structure of ku80 ctd -1.0Å AUTH Z.ZHANG,W.HU,L.CANO,T.D.LEE,D.J.CHEN,Y.CHENTITL SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OFTITL 2 KU80 SUGGESTS IMPORTANT SITES FOR PROTEIN-PROTEINTITL 3 INTERACTIONS.REF STRUCTURE V. 12 495 2004REFN ISSN 0969-2126PMID 15016365DOI 10.1016/J.STR.2004.02.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3uiu EIF2AK2 crystal structure of apo-pkr kinase domain 2.9Å AUTH F.LI,S.LI,X.YANG,Y.SHEN,T.ZHANGTITL CRYSTAL STRUCTURE OF APO-PKR KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n00 NR1D1 crystal structure of a deletion mutant of human reverba ligand binding domain bound with an ncor id1 peptide determined to 2.60a 2.6Å AUTH C.A.PHELAN,R.T.GAMPE,M.H.LAMBERT,D.J.PARKS,V.MONTANA,AUTH 2 J.BYNUM,T.M.BRODERICK,X.HU,S.P.WILLIAMS,R.T.NOLTE,M.A.LAZARTITL STRUCTURE OF REV-ERBALPHA BOUND TO N-COR REVEALS A UNIQUETITL 2 MECHANISM OF NUCLEAR RECEPTOR-CO-REPRESSOR INTERACTION.REF NAT.STRUCT.MOL.BIOL. V. 17 808 2010REFN ISSN 1545-9993PMID 20581824DOI 10.1038/NSMB.1860 […]
General Structure Information 1fg9 IFNGR1 3:1 complex of interferon-gamma receptor with interferon- gamma dimer 2.9Å AUTH D.J.THIEL,M.H.LE DU,R.L.WALTER,A.DARCY,C.CHENE,AUTH 2 M.FOUNTOULAKIS,G.GAROTTA,F.K.WINKLER,S.E.EALICKTITL OBSERVATION OF AN UNEXPECTED THIRD RECEPTORTITL 2 MOLECULE IN THE CRYSTAL STRUCTURE OF HUMANTITL 3 INTERFERON-GAMMA RECEPTOR COMPLEX.REF STRUCTURE FOLD.DES. V. 8 927 2000REFN ISSN 0969-2126PMID 10986460DOI 10.1016/S0969-2126(00)00184-2 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]