Assessment of Structural Intolerance and Durability
General Structure Information 3gd7 CFTR crystal structure of human nbd2 complexed with n6- phenylethyl-atp (p-atp) 2.7Å AUTH S.ATWELL,S.ANTONYSAMY,W.B.GUGGINO,K.CONNERS,AUTH 2 S.EMTAGE,T.GHEYI,J.F.HUNT,H.A.LEWIS,F.LU,AUTH 3 J.M.SAUDER,P.C.WEBER,D.WETMORE,X.ZHAOTITL CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITHTITL 2 N6-PHENYLETHYL-ATP (P-ATP)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1sbx SKI crystal structure of the dachshund-homology domain of human ski 1.65Å AUTH J.J.WILSON,M.MALAKHOVA,R.ZHANG,A.JOACHIMIAK,AUTH 2 R.S.HEGDETITL CRYSTAL STRUCTURE OF THE DACHSHUND HOMOLOGY DOMAINTITL 2 OF HUMAN SKIREF STRUCTURE V. 12 785 2004REFN ISSN 0969-2126PMID 15130471DOI 10.1016/J.STR.2004.02.035 Variant Set Distributions Mapped Variants
General Structure Information 3g04 TSHR crystal structure of the tsh receptor in complex with a thyroid- stimulating autoantibody 2.55Å AUTH J.SANDERS,D.Y.CHIRGADZE,P.SANDERS,S.BAKER,A.SULLIVAN,AUTH 2 A.BHARDWAJA,J.BOLTON,M.REEVE,N.NAKATAKE,M.EVANS,T.RICHARDS,AUTH 3 M.POWELL,R.N.MIGUEL,T.L.BLUNDELL,J.FURMANIAK,B.R.SMITHTITL CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH ATITL 2 THYROID-STIMULATING AUTOANTIBODYREF THYROID V. 17 395 2007REFN ISSN 1050-7256PMID 17542669DOI 10.1089/THY.2007.0034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2jxd SPINK2 nmr structure of human serine protease inhibitor kazal type ii (spink2) -1.0Å AUTH T.CHEN,T.-R.LEE,W.-G.LIANG,W.-S.W.CHANG,P.-C.LYUTITL IDENTIFICATION OF TRYPSIN-INHIBITORY SITE ANDTITL 2 STRUCTURE DETERMINATION OF HUMAN SPINK2 SERINETITL 3 PROTEINASE INHIBITORREF PROTEINS V. 77 209 2009REFN ISSN 0887-3585PMID 19422058DOI 10.1002/PROT.22432 Variant Set Distributions Mapped Variants
General Structure Information 2ksr CHRNB2 nmr structures of tm domain of the n-acetylcholine receptor b2 subunit -1.0Å AUTH V.BONDARENKO,T.TILLMAN,Y.XU,P.TANGTITL NMR STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THETITL 2 N-ACETYLCHOLINE RECEPTOR BETA2 SUBUNIT.REF BIOCHIM.BIOPHYS.ACTA V.1798 1608 2010REFN ISSN 0006-3002PMID 20441771DOI 10.1016/J.BBAMEM.2010.04.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×59 HARS solution structures of the whep-trs domain of human histidyl-trna synthetase -1.0Å AUTH N.NAMEKI,A.SASAGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE WHEP-TRS DOMAIN OFTITL 2 HUMAN HISTIDYL-TRNA SYNTHETASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3se4 IFNAR1 human ifnw-ifnar ternary complex 3.5Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yqf ANK1 solution structure of the death domain of ankyrin-1 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEATH DOMAIN OF ANKYRIN-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rel PI3 solution structure of r-elafin, a specific inhibitor of elastase, nmr, 11 structures -1.0Å AUTH C.FRANCART,M.DAUCHEZ,A.J.ALIX,G.LIPPENSTITL SOLUTION STRUCTURE OF R-ELAFIN, A SPECIFICTITL 2 INHIBITOR OF ELASTASE.REF J.MOL.BIOL. V. 268 666 1997REFN ISSN 0022-2836PMID 9171290DOI 10.1006/JMBI.1997.0983 Variant Set Distributions Mapped Variants
General Structure Information 2bgd PTPN1 structure-based design of protein tyrosine phosphatase-1b inhibitors 2.4Å AUTH E.BLACK,J.BREED,A.L.BREEZE,K.EMBREY,R.GARCIA,T.W.GERO,AUTH 2 L.GODFREY,P.W.KENNY,A.D.MORLEY,C.A.MINSHULL,A.D.PANNIFER,AUTH 3 J.READ,A.REES,D.J.RUSSELL,D.TOADER,J.TUCKERTITL STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1BTITL 2 INHIBITORSREF BIOORG.MED.CHEM.LETT. V. 15 2503 2005REFN ISSN 0960-894XPMID 15863305DOI 10.1016/J.BMCL.2005.03.068 Variant Set Distributions Mapped Variants