Assessment of Structural Intolerance and Durability
General Structure Information 3f1p ARNT crystal structure of a high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains 1.17Å AUTH T.H.SCHEUERMANN,D.R.TOMCHICK,M.MACHIUS,Y.GUO,AUTH 2 R.K.BRUICK,K.H.GARDNERTITL ARTIFICIAL LIGAND BINDING WITHIN THE HIF2ALPHATITL 2 PAS-B DOMAIN OF THE HIF2 TRANSCRIPTION FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 106 450 2009REFN ISSN 0027-8424PMID 19129502DOI 10.1073/PNAS.0808092106 Variant Set Distributions Mapped Variants
General Structure Information 2hzd TEAD1 nmr structure of the dna-binding tea domain and insights into tef-1 function -1.0Å AUTH A.ANBANANDAM,D.C.ALBARADO,C.T.NGUYEN,G.HALDER,AUTH 2 X.GAO,S.VEERARAGHAVANTITL INSIGHTS INTO TRANSCRIPTION ENHANCER FACTOR 1TITL 2 (TEF-1) ACTIVITY FROM THE SOLUTION STRUCTURE OFTITL 3 THE TEA DOMAIN.REF PROC.NATL.ACAD.SCI.USA V. 103 17225 2006REFN ISSN 0027-8424PMID 17085591DOI 10.1073/PNAS.0607171103 Variant Set Distributions Mapped Variants
General Structure Information 2qon EPHA3 human epha3 kinase and juxtamembrane region, y596f:y602f:y742a triple mutant 1.79Å AUTH T.L.DAVIS,J.R.WALKER,P.LOPPNAU,C.BUTLER-COLE,AUTH 2 A.ALLALI-HASSANI,S.DHE-PAGANONTITL AUTOREGULATION BY THE JUXTAMEMBRANE REGION OF THE HUMANTITL 2 EPHRIN RECEPTOR TYROSINE KINASE A3 (EPHA3).REF STRUCTURE V. 16 873 2008REFN ISSN 0969-2126PMID 18547520DOI 10.1016/J.STR.2008.03.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4duq S100A2 the structure of ca2+-loaded s100a2 at 1.3a resolution 1.3Å AUTH M.KOCH,G.FRITZTITL THE STRUCTURE OF CA2+-LOADED S100A2 AT 1.3- ANGSTROMTITL 2 RESOLUTION.REF FEBS J. V. 279 1799 2012REFN ISSN 1742-464XPMID 22394450DOI 10.1111/J.1742-4658.2012.08556.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kg4 GADD45A three-dimensional structure of human gadd45alpha in solution by nmr -1.0Å AUTH R.SANCHEZ,D.PANTOJA-UCEDA,J.PRIETO,T.DIERCKS,M.J.MARCAIDA,AUTH 2 G.MONTOYA,R.CAMPOS-OLIVAS,F.J.BLANCOTITL SOLUTION STRUCTURE OF HUMAN GROWTH ARREST AND DNA DAMAGETITL 2 45ALPHA (GADD45ALPHA) AND ITS INTERACTIONS WITHTITL 3 PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) AND AURORA ATITL 4 KINASEREF J.BIOL.CHEM. V. 285 22196 2010REFN ISSN 0021-9258PMID 20460379DOI 10.1074/JBC.M109.069344 […]
General Structure Information 2hw5 ECHS1 the crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1 2.55Å AUTH A.P.TURNBULL,E.SALAH,F.NIESEN,J.DEBRECZENI,E.UGOCHUKWU,AUTH 2 A.C.W.PIKE,K.KAVANAGH,O.GILEADI,F.GORREC,C.UMEANO,AUTH 3 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 4 U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN ENOYL-COENZYME A (COA)TITL 2 HYDRATASE SHORT CHAIN 1, ECHS1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1prx PRDX6 horf6 a novel human peroxidase enzyme 2.0Å AUTH H.J.CHOI,S.W.KANG,C.H.YANG,S.G.RHEE,S.E.RYUTITL CRYSTAL STRUCTURE OF A NOVEL HUMAN PEROXIDASETITL 2 ENZYME AT 2.0 A RESOLUTION.REF NAT.STRUCT.BIOL. V. 5 400 1998REFN ISSN 1072-8368PMID 9587003DOI 10.1038/NSB0598-400 Variant Set Distributions Mapped Variants
General Structure Information 3w1w FECH protein-drug complex 2.01Å AUTH V.GUPTA,S.LIU,H.ANDO,R.ISHII,S.TATENO,Y.KANEKO,M.YUGAMI,AUTH 2 S.SAKAMOTO,Y.YAMAGUCHI,O.NUREKI,H.HANDATITL SALICYLIC ACID INDUCES MITOCHONDRIAL INJURY BY INHIBITINGTITL 2 FERROCHELATASE HEME BIOSYNTHESIS ACTIVITYREF MOL.PHARMACOL. V. 84 824 2013REFN ISSN 0026-895XPMID 24043703DOI 10.1124/MOL.113.087940 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4luo RPA1 fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions 1.54Å AUTH A.O.FRANK,M.D.FELDKAMP,J.P.KENNEDY,A.G.WATERSON,N.F.PELZ,AUTH 2 J.D.PATRONE,B.VANGAMUDI,D.V.CAMPER,O.W.ROSSANESE,W.J.CHAZIN,AUTH 3 S.W.FESIKTITL DISCOVERY OF A POTENT INHIBITOR OF REPLICATION PROTEIN ATITL 2 PROTEIN-PROTEIN INTERACTIONS USING A FRAGMENT-LINKINGTITL 3 APPROACH.REF J.MED.CHEM. V. 56 9242 2013REFN ISSN 0022-2623PMID 24147804DOI 10.1021/JM401333U Variant Set Distributions Mapped Variants
General Structure Information 2wfn FLNA filamin a actin binding domain 3.2Å AUTH S.RUSKAMO,J.YLANNETITL STRUCTURE OF THE HUMAN FILAMIN A ACTIN-BINDING DOMAINREF ACTA CRYSTALLOGR.,SECT.D V. 65 1217 2009REFN ISSN 0907-4449PMID 19923718DOI 10.1107/S0907444909037330 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants