Assessment of Structural Intolerance and Durability
General Structure Information 2c6b MDM2 solution structure of the c4 zinc-finger domain of hdm2 -1.0Å AUTH G.W.YU,M.D.ALLEN,A.ANDREEVA,A.R.FERSHT,M.BYCROFTTITL SOLUTION STRUCTURE OF THE C4 ZINC FINGER DOMAIN OFTITL 2 HDM2.REF PROTEIN SCI. V. 15 384 2006REFN ISSN 0961-8368PMID 16385008DOI 10.1110/PS.051927306 Variant Set Distributions Mapped Variants
General Structure Information 2vqv HDAC4 structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor 3.3Å AUTH M.J.BOTTOMLEY,P.LO SURDO,P.DI GIOVINE,A.CIRILLO,AUTH 2 R.SCARPELLI,F.FERRIGNO,P.JONES,P.NEDDERMANN,AUTH 3 R.DE FRANCESCO,C.STEINKUHLER,P.GALLINARI,A.CARFITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMANTITL 2 HDAC4 CATALYTIC DOMAIN REVEALS A REGULATORYTITL 3 STRUCTURAL ZINC-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 26694 2008REFN ISSN 0021-9258PMID […]
General Structure Information 1c9q XIAP average nmr solution structure of the bir-2 domain of xiap -1.0Å AUTH C.SUN,M.CAI,A.H.GUNASEKERA,R.P.MEADOWS,H.WANG,AUTH 2 J.CHEN,H.ZHANG,W.WU,N.XU,S.C.NG,S.W.FESIKTITL NMR STRUCTURE AND MUTAGENESIS OF THETITL 2 INHIBITOR-OF-APOPTOSIS PROTEIN XIAP.REF NATURE V. 401 818 1999REFN ISSN 0028-0836PMID 10548111DOI 10.1038/44617 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v55 RND3 mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure 3.7Å AUTH D.KOMANDER,R.GARG,P.T.C.WAN,A.J.RIDLEY,D.BARFORDTITL MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM ATITL 2 ROCK-I:RHOE COMPLEX STRUCTURE.REF EMBO J. V. 27 3175 2008REFN ISSN 0261-4189PMID 18946488DOI 10.1038/EMBOJ.2008.226 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1rly GTF2B rdc-derived models of the zinc ribbon domain of human general transcription tfiib (zinc bound structures) -1.0Å AUTH M.GHOSH,L.M.ELSBY,T.K.MAL,J.M.GOODING,S.G.ROBERTS,AUTH 2 M.IKURATITL PROBING ZN2+-BINDING EFFECTS ON THE ZINC-RIBBONTITL 2 DOMAIN OF HUMAN GENERAL TRANSCRIPTION FACTOR TFIIB.REF BIOCHEM.J. V. 378 317 2004REFN ISSN 0264-6021PMID 14641108DOI 10.1042/BJ20031706 Variant Set Distributions Mapped Variants
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants
General Structure Information 2vjf MDM2 crystal structure of the mdm2-mdmx ring domain heterodimer 2.3Å AUTH K.LINKE,P.D.MACE,C.A.SMITH,D.L.VAUX,J.SILKE,C.L.DAYTITL STRUCTURE OF THE MDM2/MDMX RING DOMAIN HETERODIMERTITL 2 REVEALS DIMERIZATION IS REQUIRED FOR THEIRTITL 3 UBIQUITYLATION IN TRANS.REF CELL DEATH DIFFER. V. 15 841 2008REFN ISSN 1350-9047PMID 18219319DOI 10.1038/SJ.CDD.4402309 Variant Set Distributions Mapped Variants
General Structure Information 1zy7 ADARB1 crystal structure of the catalytic domain of an adenosine deaminase that acts on rna (hadar2) bound to inositol hexakisphosphate (ihp) 1.7Å AUTH M.R.MACBETH,H.L.SCHUBERT,A.P.VANDEMARK,A.T.LINGAM,AUTH 2 C.P.HILL,B.L.BASSTITL INOSITOL HEXAKISPHOSPHATE IS BOUND IN THE ADAR2TITL 2 CORE AND REQUIRED FOR RNA EDITING.REF SCIENCE V. 309 1534 2005REFN ISSN 0036-8075PMID 16141067DOI 10.1126/SCIENCE.1113150 Variant Set […]
General Structure Information 3qln ATRX crystal structure of atrx add domain in free state 1.9Å AUTH S.IWASE,B.XIANG,S.GHOSH,T.REN,P.W.LEWIS,J.C.COCHRANE,AUTH 2 C.D.ALLIS,D.J.PICKETTS,D.J.PATEL,H.LI,Y.SHITITL ATRX ADD DOMAIN LINKS AN ATYPICAL HISTONE METHYLATIONTITL 2 RECOGNITION MECHANISM TO HUMAN MENTAL-RETARDATION SYNDROMEREF NAT.STRUCT.MOL.BIOL. V. 18 769 2011REFN ISSN 1545-9993PMID 21666679DOI 10.1038/NSMB.2062 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3e37 FNTA protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5 1.8Å AUTH M.A.HAST,S.FLETCHER,C.G.CUMMINGS,E.E.PUSATERI,AUTH 2 M.A.BLASKOVICH,K.RIVAS,M.H.GELB,W.C.VAN VOORHIS,AUTH 3 S.M.SEBTI,A.D.HAMILTON,L.S.BEESETITL STRUCTURAL BASIS FOR BINDING AND SELECTIVITY OFTITL 2 ANTIMALARIAL AND ANTICANCER ETHYLENEDIAMINETITL 3 INHIBITORS TO PROTEIN FARNESYLTRANSFERASE.REF CHEM.BIOL. V. 16 181 2009REFN ISSN 1074-5521PMID 19246009DOI 10.1016/J.CHEMBIOL.2009.01.014 Variant Set Distributions Ripley’s K Analysis Plots […]