Assessment of Structural Intolerance and Durability
General Structure Information 2qgx UBE2Q1 ubiquitin-conjugating enzyme e2q 2.56Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2yre FBXO30 solution structure of the zinc finger domains (1-87) from human f-box only protein -1.0Å AUTH T.NAGASHIMA,T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER DOMAINSTITL 2 (1-87) FROM HUMAN F-BOX ONLY PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jxx NFATC2IP nmr solution structure of ubiquitin-like domain of nfatc2ip. northeast structural genomics consortium target hr5627 -1.0Å AUTH R.S.DOHERTY,S.DHE-PAGANON,C.FARES,A.LEMAK,C.BUTLER,AUTH 2 S.SRISAILAM,M.KARRA,A.YEE,J.WEIGELT,A.M.EDWARDS,AUTH 3 C.H.ARROWSMITHTITL SOLUTION STRUCTURE OF UBIQUITIN-LIKE DOMAIN OFTITL 2 NFATC2IP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nvu UBA3 structure of appbp1-uba3~nedd8-nedd8-mgatp-ubc12(c111a), a trapped ubiquitin-like protein activation complex 2.8Å AUTH D.T.HUANG,H.W.HUNT,M.ZHUANG,M.D.OHI,J.M.HOLTON,AUTH 2 B.A.SCHULMANTITL BASIS FOR A UBIQUITIN-LIKE PROTEIN THIOESTERTITL 2 SWITCH TOGGLING E1-E2 AFFINITY.REF NATURE V. 445 394 2007REFN ISSN 0028-0836PMID 17220875DOI 10.1038/NATURE05490 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cs4 RASSF8 solution structure of n-terminal domain of chromosome 12 open reading frame 2 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF N-TERMINAL DOMAIN OFTITL 2 CHROMOSOME 12 OPEN READING FRAME 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vpj KLHL12 crystal structure of the kelch domain of human klhl12 1.85Å AUTH P.CANNING,C.D.O.COOPER,T.KROJER,J.W.MURRAY,A.C.W.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,B.D.MARSDEN,AUTH 3 O.GILEADI,S.KNAPP,F.VON DELFT,A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 ASSEMBLY WITH THE BTB-KELCHTITL 2 FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 Variant Set Distributions Mapped Variants
General Structure Information 1zdn UBE2S ubiquitin-conjugating enzyme e2s 1.93Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4orh UBE2V2 crystal structure of rnf8 bound to the ubc13/mms2 heterodimer 4.8Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 4kit PRPF8 crystal structure of human brr2 in complex with the prp8 jab1/mpn domain 3.6Å AUTH S.MOZAFFARI-JOVIN,T.WANDERSLEBEN,K.F.SANTOS,C.L.WILL,AUTH 2 R.LUHRMANN,M.C.WAHLTITL INHIBITION OF RNA HELICASE BRR2 BY THE C-TERMINAL TAIL OFTITL 2 THE SPLICEOSOMAL PROTEIN PRP8.REF SCIENCE V. 341 80 2013REFN ISSN 0036-8075PMID 23704370DOI 10.1126/SCIENCE.1237515 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kr0 ADRM1 a proteasome protein -1.0Å AUTH X.CHEN,B.H.LEE,D.FINLEY,K.J.WALTERSTITL STRUCTURE OF PROTEASOME UBIQUITIN RECEPTOR HRPN13 AND ITSTITL 2 ACTIVATION BY THE SCAFFOLDING PROTEIN HRPN2.REF MOL.CELL V. 38 404 2010REFN ISSN 1097-2765PMID 20471946DOI 10.1016/J.MOLCEL.2010.04.019 Variant Set Distributions Mapped Variants