General Structure Information 4j6s YWHAG 14-3-3gamma complexed with the n-terminal sequence of tyrosine hydroxylase (residues 1-43) 3.08Å AUTH A.A.SKJEVIK,M.MILENI,A.BAUMANN,O.HALSKAU,K.TEIGEN,AUTH 2 R.C.STEVENS,A.MARTINEZTITL THE N-TERMINAL SEQUENCE OF TYROSINE HYDROXYLASE IS ATITL 2 CONFORMATIONALLY VERSATILE MOTIF THAT BINDS 14-3-3 PROTEINSTITL 3 AND MEMBRANES.REF J.MOL.BIOL. V. 426 150 2014REFN ISSN 0022-2836PMID 24055376DOI 10.1016/J.JMB.2013.09.012 Variant Set Distributions Mapped Variants
General Structure Information 2ys2 BMX solution structure of the btk motif of human cytoplasmic tyrosine-protein kinase bmx -1.0Å AUTH H.ABE,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,M.YONEYAMA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BTK MOTIF OF HUMANTITL 2 CYTOPLASMIC TYROSINE-PROTEIN KINASE BMXREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qs7 FLT3LG crystal structure of a human flt3 ligand-receptor ternary complex 4.3Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Mapped Variants
General Structure Information 1z57 CLK1 crystal structure of human clk1 in complex with 10z-hymenialdisine 1.7Å AUTH A.N.BULLOCK,S.DAS,J.E.DEBRECZENI,P.RELLOS,O.FEDOROV,AUTH 2 F.H.NIESEN,K.GUO,E.PAPAGRIGORIOU,A.L.AMOS,S.CHO,B.E.TURK,AUTH 3 G.GHOSH,S.KNAPPTITL KINASE DOMAIN INSERTIONS DEFINE DISTINCT ROLES OF CLKTITL 2 KINASES IN SR PROTEIN PHOSPHORYLATION.REF STRUCTURE V. 17 352 2009REFN ISSN 0969-2126PMID 19278650DOI 10.1016/J.STR.2008.12.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ekx BMX solution structure of the human bmx sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN BMX SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m59 KDR spatial structure of dimeric vegfr2 membrane domain in dpc micelles -1.0Å AUTH K.S.MINEEV,A.S.ARSENIEV,M.A.SHULEPKO,E.N.LYUKMANOVATITL SPATIAL STRUCTURE OF DIMERIC VEGFR2 MEMBRANE DOMAIN IN DPCTITL 2 MICELLESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bsj FLT4 crystal structure of vegfr-3 extracellular domains d4-5 2.5Å AUTH V.-M.LEPPANEN,D.TVOROGOV,K.KISKO,A.E.PROTA,M.JELTSCH,AUTH 2 A.ANISIMOV,S.MARKOVIC-MUELLER,E.STUTTFELD,K.N.GOLDIE,AUTH 3 K.BALLMER-HOFER,K.ALITALOTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO VEGFR-3 LIGANDTITL 2 BINDING AND ACTIVATIONREF PROC.NATL.ACAD.SCI.USA V. 110 12960 2013REFN ISSN 0027-8424PMID 23878260DOI 10.1073/PNAS.1301415110 Variant Set Distributions Mapped Variants
General Structure Information 3qs9 FLT3 crystal structure of a human flt3 ligand-receptor ternary complex 7.8Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3isq HPD crystal structure of human 4-hydroxyphenylpyruvate dioxygenase 1.75Å AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d7u CSK structural basis for the recognition of c-src by its inactivator csk 4.11Å AUTH N.M.LEVINSON,M.A.SEELIGER,P.A.COLE,J.KURIYANTITL STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITSTITL 2 INACTIVATOR CSK.REF CELL(CAMBRIDGE,MASS.) V. 134 124 2008REFN ISSN 0092-8674PMID 18614016DOI 10.1016/J.CELL.2008.05.051 Variant Set Distributions Mapped Variants