Assessment of Structural Intolerance and Durability
General Structure Information 2el8 STAP2 solution structure of the human stap2 sh2 domain -1.0Å AUTH T.KASAI,K.MIYAMOTO,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN STAP2 SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fnw ALK crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain 1.75Å AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4gfv PTPN18 ptpn18 in complex with her2-py1196 phosphor-peptides 2.1Å AUTH H.M.WANG,F.YANG,Y.J.DU,D.X.YANG,Y.ZHANG,X.YU,J.P.SUNTITL PTPN18-HER2 PEPTIDESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kvw DYRK2 crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (dyrk2) in complex with an indirubin ligand 2.28Å AUTH P.FILIPPAKOPOULOS,V.MYRIANTHOPOULOS,M.KRITSANIDA,P.MAGIATIS,AUTH 2 A.L.SKALTSOUNIS,M.SOUNDARARAJAN,T.KROJER,O.GILEADI,E.HAPKA,AUTH 3 O.FEDOROV,G.BERRIDGE,J.WANG,L.SHRESTHA,M.VOLLMAR,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 5 E.MIKROS,S.KNAPPTITL CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINETITL 2 PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITHTITL 3 AN INDIRUBIN LIGANDREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 2ysx INPP5D solution structure of the human ship sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN SHIP SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3s4e DUSP19 crystal structrue of a novel mitogen-activated protein kinase phosphatase, skrp1 1.26Å AUTH C.H.WEI,S.Y.RYU,Y.H.JEON,M.Y.YOON,D.G.JEONG,S.J.KIM,S.E.RYUTITL CRYSTAL STRUCTURE OF A NOVEL MITOGEN-ACTIVATED PROTEINTITL 2 KINASE PHOSPHATASE, SKRP1.REF PROTEINS V. 79 3242 2011REFN ISSN 0887-3585PMID 21989941DOI 10.1002/PROT.23156 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i1y PTPRN crystal structure of the phosphatase domain of human ptp ia-2 2.23Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,T.P.DILORENZO,AUTH 2 V.MALASHKEVICH,S.R.WASSERMAN,S.SWAMINATHAN,S.ESWARAMOORTHY,AUTH 3 R.AGARWAL,D.KUMARAN,M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,AUTH 4 J.ALVARADO,U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 5 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASESREF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4dkd IL34 crystal structure of human interleukin-34 bound to human csf-1r 3.0Å AUTH X.MA,W.Y.LIN,Y.CHEN,S.STAWICKI,K.MUKHYALA,Y.WU,F.MARTIN,AUTH 2 J.F.BAZAN,M.A.STAROVASNIKTITL STRUCTURAL BASIS FOR THE DUAL RECOGNITION OF HELICALTITL 2 CYTOKINES IL-34 AND CSF-1 BY CSF-1R.REF STRUCTURE V. 20 676 2012REFN ISSN 0969-2126PMID 22483114DOI 10.1016/J.STR.2012.02.010 Variant Set Distributions Mapped Variants
General Structure Information 2g59 PTPRO crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens 2.19Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1wwc NTRK3 nt3 binding domain of human trkc receptor 1.9Å AUTH M.H.ULTSCH,C.WIESMANN,L.C.SIMMONS,J.HENRICH,M.YANG,D.REILLY,AUTH 2 S.H.BASS,A.M.DE VOSTITL CRYSTAL STRUCTURES OF THE NEUROTROPHIN-BINDING DOMAIN OFTITL 2 TRKA, TRKB AND TRKC.REF J.MOL.BIOL. V. 290 149 1999REFN ISSN 0022-2836PMID 10388563DOI 10.1006/JMBI.1999.2816 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants