Assessment of Structural Intolerance and Durability
General Structure Information 3f1i STAM human escrt-0 core complex 2.3Å AUTH X.REN,D.P.KLOER,Y.C.KIM,R.GHIRLANDO,L.F.SAIDI,G.HUMMER,AUTH 2 J.H.HURLEYTITL HYBRID STRUCTURAL MODEL OF THE COMPLETE HUMAN ESCRT-0TITL 2 COMPLEX.REF STRUCTURE V. 17 406 2009REFN ISSN 0969-2126PMID 19278655DOI 10.1016/J.STR.2009.01.012 Variant Set Distributions Mapped Variants
General Structure Information 4fq3 TNPO1 crystal structure of transportin/fus-nls 3.0Å AUTH W.GONG,C.NIU,M.JIA,F.GAOTITL CRYSTAL STRUCTURE OF TRANSPORTIN/FUS-NLSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4has SNX27 crystal structure of px domain of human sorting nexin snx27 1.74Å AUTH D.S.FROESE,T.KROJER,C.STRAIN-DAMERELL,C.ALLERSTON,W.KIYANI,AUTH 2 N.BURGESS-BROWN,F.VON DELFT,C.ARROWSMITH,C.BOUNTRA,AUTH 3 A.EDWARDS,W.W.YUE,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PX DOMAIN OF HUMAN SORTING NEXIN SNX27REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2erx DIRAS2 crystal structure of diras2 in complex with gdp and inorganic phosphate 1.65Å AUTH E.PAPAGRIGORIOU,X.YANG,J.ELKINS,F.E.NIESEN,AUTH 2 N.BURGESS,E.SALAH,O.FEDOROV,L.J.BALL,F.VON DELFT,AUTH 3 M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,J.WEIGELT,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF DIRAS2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r02 PDCD6IP crystal structure of alix/aip1 in complex with the hiv-1 ypltsl late domain 2.6Å AUTH Q.ZHAI,R.D.FISHER,H.Y.CHUNG,D.G.MYSZKA,AUTH 2 W.I.SUNDQUIST,C.P.HILLTITL STRUCTURAL AND FUNCTIONAL STUDIES OF ALIXTITL 2 INTERACTIONS WITH YPX(N)L LATE DOMAINS OF HIV-1TITL 3 AND EIAV.REF NAT.STRUCT.MOL.BIOL. V. 15 43 2008REFN ISSN 1545-9993PMID 18066081DOI 10.1038/NSMB1319 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3i4r NUP133 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dm4 SORL1 solution structure of the second fn3 domain of human sorla/lr11 -1.0Å AUTH T.NAGASHIMA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN SORLA/LR11REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v14 KIF16B kinesin 16b phox-homology domain (kif16b) 2.2Å AUTH N.R.BLATNER,M.I.WILSON,C.LEI,W.HONG,D.MURRAY,AUTH 2 R.L.WILLIAMS,W.CHOTITL THE STRUCTURAL BASIS OF NOVEL ENDOSOME ANCHORINGTITL 2 ACTIVITY OF KIF16B KINESIN.REF EMBO J. V. 26 3709 2007REFN ISSN 0261-4189PMID 17641687DOI 10.1038/SJ.EMBOJ.7601800 Variant Set Distributions Mapped Variants
General Structure Information 3ldz STAM crystal structure of human stam1 vhs domain in complex with ubiquitin 2.6Å AUTH X.REN,J.H.HURLEYTITL VHS DOMAINS OF ESCRT-0 COOPERATE IN HIGH-AVIDITYTITL 2 BINDING TO POLYUBIQUITINATED CARGO.REF EMBO J. V. 29 1045 2010REFN ISSN 0261-4189PMID 20150893DOI 10.1038/EMBOJ.2010.6 Variant Set Distributions Mapped Variants
General Structure Information 4hlq TBC1D20 crystal structure of human rab1b bound to gdp and bef3 in complex with the gap domain of tbc1d20 from homo sapiens 3.3Å AUTH K.GAVRILJUK,E.M.GAZDAG,A.ITZEN,C.KOTTING,R.S.GOODY,K.GERWERTTITL CATALYTIC MECHANISM OF A MAMMALIAN RAB-RABGAP COMPLEX INTITL 2 ATOMIC DETAIL.REF PROC.NATL.ACAD.SCI.USA V. 109 21348 2012REFN ISSN 0027-8424PMID 23236136DOI 10.1073/PNAS.1214431110 Variant Set Distributions Ripley’s K Analysis […]