3BPR.A | MERTK

General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]

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1F3M.B | PAK1

General Structure Information 1f3m PAK1 crystal structure of human serine/threonine kinase pak1 2.3Å AUTH M.LEI,W.LU,W.MENG,M.C.PARRINI,M.J.ECK,B.J.MAYER,AUTH 2 S.C.HARRISONTITL STRUCTURE OF PAK1 IN AN AUTOINHIBITED CONFORMATIONTITL 2 REVEALS A MULTISTAGE ACTIVATION SWITCH.REF CELL(CAMBRIDGE,MASS.) V. 102 387 2000REFN ISSN 0092-8674PMID 10975528DOI 10.1016/S0092-8674(00)00043-X Variant Set Distributions Mapped Variants

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4HZS.B | TNK2

General Structure Information 4hzs TNK2 crystal structure of ack1 kinase domain with c-terminal sh3 domain 3.23Å AUTH K.S.GAJIWALA,K.MAEGLEY,R.FERRE,Y.A.HE,X.YUTITL ACK1: ACTIVATION AND REGULATION BY ALLOSTERY.REF PLOS ONE V. 8 53994 2013REFN ESSN 1932-6203PMID 23342057DOI 10.1371/JOURNAL.PONE.0053994 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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2ENZ.A | PRKCQ

General Structure Information 2enz PRKCQ solution structure of the second c1 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND C1 DOMAIN FROMTITL 2 HUMAN PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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3LQH.A | KMT2A

General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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3COM.A | STK4

General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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4FWW.A | MST1R

General Structure Information 4fww MST1R crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase 1.85Å AUTH K.L.CHAO,I.W.TSAI,C.CHEN,O.HERZBERGTITL CRYSTAL STRUCTURE OF THE SEMA-PSI EXTRACELLULAR DOMAIN OFTITL 2 HUMAN RON RECEPTOR TYROSINE KINASE.REF PLOS ONE V. 7 41912 2012REFN ESSN 1932-6203PMID 22848655DOI 10.1371/JOURNAL.PONE.0041912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]

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4BHW.B | EP300

General Structure Information 4bhw EP300 structural basis for autoinhibition of the acetyltransferase activity of p300 2.8Å AUTH M.DELVECCHIO,J.GAUCHER,C.AGUILAR-GURRIERI,E.ORTEGA,D.PANNETITL STRUCTURE OF THE P300 CATALYTIC CORE AND IMPLICATIONS FORTITL 2 CHROMATIN TARGETING AND HAT REGULATIONREF NAT.STRUCT.MOL.BIOL. V. 20 1040 2013REFN ISSN 1545-9993PMID 23934153DOI 10.1038/NSMB.2642 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]

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4ARK.A | MAP2K1

General Structure Information 4ark MAP2K1 crystal structure of the catalytic domain of human map kinase kinase 1 (mek1) in complex with a small molecule inhibitor and adp 2.6Å AUTH I.V.HARTUNG,M.HITCHCOCK,F.PUEHLER,R.NEUHAUS,A.SCHOLZ,AUTH 2 S.HAMMER,K.PETERSEN,G.SIEMEISTER,D.BRITTAIN,R.C.HILLIGTITL OPTIMIZATION OF ALLOSTERIC MEK INHIBITORS – PART 1:TITL 2 VENTURING INTO UNEXPLORED SAR TERRITORIESREF BIOORG.MED.CHEM.LETT. V. 23 2384 2013REFN ISSN 0960-894XPMID 23474388DOI 10.1016/J.BMCL.2013.02.028 […]

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2V4M.D | GFPT1

General Structure Information 2v4m GFPT1 the isomerase domain of human glutamine-fructose-6- phosphate transaminase 1 (gfpt1) in complex with fructose 6-phosphate 2.29Å AUTH M.MOCHE,L.LEHTIO,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 A.JOHANSSON,I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,AUTH 5 M.E.NILSSON,T.NYMAN,C.PERSSON,J.SAGEMARK,AUTH 6 S.SVENSSON,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 7 J.UPPENBERG,S.VAN DEN BERG,M.WELIN,M.WISNIEWSKA,AUTH 8 J.WEIGELT,P.NORDLUND,M.WIKSTROMTITL THE ISOMERASE DOMAIN OF HUMAN GFPT1 IN COMPLEXTITL 2 WITH FRUCTOSE 6-PHOSPHATEREF TO BE PUBLISHEDREFN Variant […]

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