Assessment of Structural Intolerance and Durability
General Structure Information 2jxj KDM5A nmr structure of the arid domain from the histone h3k4 demethylase rbp2 -1.0Å AUTH S.TU,Y.C.TENG,C.YUAN,Y.T.WU,M.Y.CHAN,A.N.CHENG,AUTH 2 P.H.LIN,L.J.JUAN,M.D.TSAITITL THE ARID DOMAIN OF THE H3K4 DEMETHYLASE RBP2 BINDSTITL 2 TO A DNA CCGCCC MOTIFREF NAT.STRUCT.MOL.BIOL. V. 15 419 2008REFN ISSN 1545-9993PMID 18270511DOI 10.1038/NSMB.1400 Variant Set Distributions Mapped Variants
General Structure Information 1vd4 GTF2E1 solution structure of the zinc finger domain of tfiie alpha -1.0Å AUTH M.OKUDA,A.TANAKA,Y.ARAI,M.SATOH,H.OKAMURA,AUTH 2 A.NAGADOI,F.HANAOKA,Y.OHKUMA,Y.NISHIMURATITL A NOVEL ZINC FINGER STRUCTURE IN THE LARGE SUBUNITTITL 2 OF HUMAN GENERAL TRANSCRIPTION FACTOR TFIIE.REF J.BIOL.CHEM. V. 279 51395 2004REFN ISSN 0021-9258PMID 15385556DOI 10.1074/JBC.M404722200 Variant Set Distributions Mapped Variants
General Structure Information 3f1p ARNT crystal structure of a high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains 1.17Å AUTH T.H.SCHEUERMANN,D.R.TOMCHICK,M.MACHIUS,Y.GUO,AUTH 2 R.K.BRUICK,K.H.GARDNERTITL ARTIFICIAL LIGAND BINDING WITHIN THE HIF2ALPHATITL 2 PAS-B DOMAIN OF THE HIF2 TRANSCRIPTION FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 106 450 2009REFN ISSN 0027-8424PMID 19129502DOI 10.1073/PNAS.0808092106 Variant Set Distributions Mapped Variants
General Structure Information 1h5p SP100 solution structure of the human sp100b sand domain by heteronuclear nmr. -1.0Å AUTH M.J.BOTTOMLEY,M.W.COLLARD,J.I.HUGGENVIK,Z.LIU,AUTH 2 T.J.GIBSON,M.SATTLERTITL THE SAND DOMAIN STRUCTURE DEFINES A NOVEL DNATITL 2 BINDING FOLD IN TRANSCRIPTIONAL REGULATIONREF NAT.STRUCT.BIOL. V. 8 626 2001REFN ISSN 1072-8368PMID 11427895DOI 10.1038/89675 Variant Set Distributions Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 6pax PAX6 crystal structure of the human pax-6 paired domain-dna complex reveals a general model for pax protein-dna interactions 2.5Å AUTH H.E.XU,M.A.ROULD,W.XU,J.A.EPSTEIN,R.L.MAAS,C.O.PABOTITL CRYSTAL STRUCTURE OF THE HUMAN PAX6 PAIREDTITL 2 DOMAIN-DNA COMPLEX REVEALS SPECIFIC ROLES FOR THETITL 3 LINKER REGION AND CARBOXY-TERMINAL SUBDOMAIN INTITL 4 DNA BINDING.REF GENES DEV. V. 13 1263 […]
General Structure Information 1x0j BRD2 crystal structure analysis of the n-terminal bromodomain of human brd2 1.8Å AUTH Y.NAKAMURA,T.UMEHARA,M.SHIROUZU,B.PADMANABHAN,AUTH 2 S.YOKOYAMATITL STRUCTURAL BASIS FOR ACETYLATED HISTONE H4TITL 2 RECOGNITION BY THE HUMAN BRD2 BROMODOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4kfz LMO2 crystal structure of lmo2 and anti-lmo2 vh complex 2.8Å AUTH H.SEWELL,T.TANAKA,K.E.OMARI,E.J.MANCINI,A.CRUZ,AUTH 2 N.FERNANDEZ-FUENTES,J.CHAMBERS,T.H.RABBITTSTITL CONFORMATIONAL FLEXIBILITY OF THE ONCOGENIC PROTEIN LMO2TITL 2 PRIMES THE FORMATION OF THE MULTI-PROTEIN TRANSCRIPTIONTITL 3 COMPLEX.REF SCI REP V. 4 3643 2014REFN ESSN 2045-2322PMID 24407558DOI 10.1038/SREP03643 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ri4 ETS1 ets1 cooperative binding to widely separated sites on promoter dna 3.0Å AUTH N.D.BABAYEVA,O.I.BARANOVSKAYA,T.H.TAHIROVTITL STRUCTURAL BASIS OF ETS1 COOPERATIVE BINDING TO WIDELYTITL 2 SEPARATED SITES ON PROMOTER DNA.REF PLOS ONE V. 7 33698 2012REFN ESSN 1932-6203PMID 22432043DOI 10.1371/JOURNAL.PONE.0033698 Variant Set Distributions Mapped Variants
General Structure Information 4bqa ETS2 crystal structure of the ets domain of human ets2 in complex with dna 2.5Å AUTH J.A.NEWMAN,C.D.O.COOPER,H.AITKENHEAD,O.GILEADITITL STRUCTURAL INSIGHTS INTO THE AUTOREGULATION ANDTITL 2 COOPERATIVITY OF THE HUMAN TRANSCRIPTION FACTOR ETS-2.REF J.BIOL.CHEM. V. 290 8539 2015REFN ISSN 0021-9258PMID 25670864DOI 10.1074/JBC.M114.619270 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]