Assessment of Structural Intolerance and Durability
General Structure Information 4iqr HNF4A multi-domain organization of the hnf4alpha nuclear receptor complex on dna 2.9Å AUTH V.CHANDRA,P.HUANG,N.POTLURI,D.WU,Y.KIM,F.RASTINEJADTITL MULTIDOMAIN INTEGRATION IN THE STRUCTURE OF THE HNF-4 ALPHATITL 2 NUCLEAR RECEPTOR COMPLEX.REF NATURE V. 495 394 2013REFN ISSN 0028-0836PMID 23485969DOI 10.1038/NATURE11966 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 2lce BCL6 chemical shift assignment of hr4436b from homo sapiens, northeast structural genomics consortium -1.0Å AUTH H.LEE,G.T.MONTELIONE,J.H.PRESTEGARDTITL SOLUTION STRUCTURE OF HR4436B.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bim BCL6 crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide 2.6Å AUTH A.F.GHETU,C.M.CORCORAN,L.CERCHIETTI,V.J.BARDWELL,AUTH 2 A.MELNICK,G.G.PRIVETITL STRUCTURE OF A BCOR COREPRESSOR PEPTIDE IN COMPLEXTITL 2 WITH THE BCL6 BTB DOMAIN DIMER.REF MOL.CELL V. 29 384 2008REFN ISSN 1097-2765PMID 18280243DOI 10.1016/J.MOLCEL.2007.12.026 Variant Set Distributions Mapped Variants
General Structure Information 3gdq HSPA1L crystal structure of the human 70kda heat shock protein 1-like atpase domain in complex with adp and inorganic phosphate 1.8Å AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,T.KOTENYOVA,AUTH 2 M.MOCHE,H.SCHULERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOUR HUMAN HSP70TITL 2 ISOFORMS: HSPA1L/HSP70-HOM, HSPA2/HSP70-2, HSPA6/HSP70B,TITL 3 AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN 1932-6203PMID […]
General Structure Information 2gl7 CTNNB1 crystal structure of a beta-catenin/bcl9/tcf4 complex 2.6Å AUTH J.SAMPIETRO,C.L.DAHLBERG,U.S.CHO,T.R.HINDS,D.KIMELMAN,W.XUTITL CRYSTAL STRUCTURE OF A BETA-CATENIN/BCL9/TCF4 COMPLEX.REF MOL.CELL V. 24 293 2006REFN ISSN 1097-2765PMID 17052462DOI 10.1016/J.MOLCEL.2006.09.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3aad TAF1 structure of the histone chaperone cia/asf1-double bromodomain complex linking histone modifications and site-specific histone eviction 3.3Å AUTH Y.AKAI,N.ADACHI,Y.HAYASHI,M.EITOKU,N.SANO,R.NATSUME,N.KUDO,AUTH 2 M.TANOKURA,T.SENDA,M.HORIKOSHITITL STRUCTURE OF THE HISTONE CHAPERONE CIA/ASF1-DOUBLETITL 2 BROMODOMAIN COMPLEX LINKING HISTONE MODIFICATIONS ANDTITL 3 SITE-SPECIFIC HISTONE EVICTIONREF PROC.NATL.ACAD.SCI.USA V. 107 8153 2010REFN ISSN 0027-8424PMID 20393127DOI 10.1073/PNAS.0912509107 Variant Set Distributions Ripley’s […]
General Structure Information 3cjw NR2F2 crystal structure of the human coup-tfii ligand binding domain 1.48Å AUTH S.W.KRUSE,K.SUINO-POWELL,X.E.ZHOU,J.E.KRETSCHMAN,AUTH 2 R.REYNOLDS,C.VONRHEIN,Y.XU,L.WANG,S.Y.TSAI,AUTH 3 M.J.TSAI,H.E.XUTITL IDENTIFICATION OF COUP-TFII ORPHAN NUCLEARTITL 2 RECEPTOR AS A RETINOIC ACID-ACTIVATED RECEPTOR.REF PLOS BIOL. V. 6 E227 2008REFN ISSN 1544-9173PMID 18798693DOI 10.1371/JOURNAL.PBIO.0060227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3ndq TCEA1 structure of human tfiis domain ii 1.93Å AUTH X.YE,A.GNATT,X.P.HUTITL STRUCTURE OF HUMAN TFIIS DOMAIN IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qw4 NR4A1 human nr4a1 ligand-binding domain 2.8Å AUTH J.R.MIN,A.SCHUETZ,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN NR4A1 LIGAND-BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants