Assessment of Structural Intolerance and Durability
General Structure Information 3g73 FOXM1 structure of the foxm1 dna binding 2.21Å AUTH D.R.LITTLER,M.ALVAREZ-FERNANDEZ,A.STEIN,R.G.HIBBERT,AUTH 2 T.HEIDEBRECHT,P.ALOY,R.H.MEDEMA,A.PERRAKISTITL STRUCTURE OF THE FOXM1 DNA-RECOGNITION DOMAIN BOUND TO ATITL 2 PROMOTER SEQUENCEREF NUCLEIC ACIDS RES. 2010REFN ESSN 1362-4962PMID 20360045DOI 10.1093/NAR/GKQ194 Variant Set Distributions Mapped Variants
General Structure Information 3gwx PPARD molecular recognition of fatty acids by peroxisome proliferator-activated receptors 2.4Å AUTH H.E.XU,M.H.LAMBERT,V.G.MONTANA,D.J.PARKS,AUTH 2 S.G.BLANCHARD,P.J.BROWN,D.D.STERNBACH,J.M.LEHMANN,AUTH 3 G.B.WISELY,T.M.WILLSON,S.A.KLIEWER,M.V.MILBURNTITL MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOMETITL 2 PROLIFERATOR-ACTIVATED RECEPTORS.REF MOL.CELL V. 3 397 1999REFN ISSN 1097-2765PMID 10198642DOI 10.1016/S1097-2765(00)80467-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c5i MBTD1 crystal structure of mbtd1 yy1 complex 2.49Å AUTH C.ALFIERI,M.C.GAMBETTA,R.MATOS,S.GLATT,P.SEHR,S.FRATERMAN,AUTH 2 M.WILM,J.MUELLER,C.W.MUELLERTITL STRUCTURAL BASIS FOR TARGETING THE CHROMATIN REPRESSORTITL 2 SFMBT TO POLYCOMB RESPONSE ELEMENTSREF GENES DEV. V. 27 2367 2013REFN ISSN 0890-9369PMID 24186981DOI 10.1101/GAD.226621.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bkx MTA1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2xu7 RBBP4 structural basis for rbap48 binding to fog-1 1.9Å AUTH S.LEJON,S.Y.THONG,A.MURTHY,S.ALQARNI,N.V.MURZINA,G.A.BLOBEL,AUTH 2 E.D.LAUE,J.P.MACKAYTITL INSIGHTS INTO ASSOCIATION OF THE NURD COMPLEX WITH FOG-1TITL 2 FROM THE CRYSTAL STRUCTURE OF AN RBAP48-FOG- 1 COMPLEX.REF J.BIOL.CHEM. V. 286 1196 2011REFN ISSN 0021-9258PMID 21047798DOI 10.1074/JBC.M110.195842 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3vi8 PPARA human pprr alpha ligand binding domain in complex with a synthetic agonist aphm13 1.75Å AUTH N.KUWABARA,T.OYAMA,D.TOMIOKA,M.OHASHI,J.YANAGISAWA,AUTH 2 T.SHIMIZU,H.MIYACHITITL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARS) HAVETITL 2 MULTIPLE BINDING POINTS THAT ACCOMMODATE LIGANDS IN VARIOUSTITL 3 CONFORMATIONS: PHENYLPROPANOIC ACID-TYPE PPAR LIGANDS BINDTITL 4 TO PPAR IN DIFFERENT CONFORMATIONS, DEPENDING ON THE SUBTYPEREF J.MED.CHEM. […]
General Structure Information 2qpw PRDM2 methyltransferase domain of human pr domain-containing protein 2 1.79Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Mapped Variants
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]