Assessment of Structural Intolerance and Durability
General Structure Information 4l1u RTF1 crystal structure of human rtf1 plus3 domain in complex with spt5 ctr phosphopeptide 2.42Å AUTH A.D.WIER,M.K.MAYEKAR,A.HEROUX,K.M.ARNDT,A.P.VANDEMARKTITL STRUCTURAL BASIS FOR SPT5-MEDIATED RECRUITMENT OF THE PAF1TITL 2 COMPLEX TO CHROMATIN.REF PROC.NATL.ACAD.SCI.USA V. 110 17290 2013REFN ISSN 0027-8424PMID 24101474DOI 10.1073/PNAS.1314754110 Variant Set Distributions Mapped Variants
General Structure Information 2p0k SCMH1 crystal structure of scmh1 1.75Å AUTH N.HERZANYCH,G.SENISTERRA,Y.LIU,L.CROMBET,P.LOPPNAU,AUTH 2 I.KOZIERADZKI,M.VEDADI,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,J.MINTITL STRUCTURE OF SCMH1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4m6t LEO1 structure of human paf1 and leo1 complex 2.5Å AUTH X.CHU,X.QIN,H.XU,L.LI,Z.WANG,F.LI,X.XIE,H.ZHOU,Y.SHEN,J.LONGTITL STRUCTURAL INSIGHTS INTO PAF1 COMPLEX ASSEMBLY AND HISTONETITL 2 BINDINGREF NUCLEIC ACIDS RES. V. 41 10619 2013REFN ISSN 0305-1048PMID 24038468DOI 10.1093/NAR/GKT819 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zme SNF8 integrated structural and functional model of the human escrt-ii complex 2.9Å AUTH Y.J.IM,J.H.HURLEYTITL INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISMTITL 2 OF THE HUMAN ESCRT-II COMPLEXREF DEV.CELL V. 14 902 2008REFN ISSN 1534-5807PMID 18539118DOI 10.1016/J.DEVCEL.2008.04.004 Variant Set Distributions Mapped Variants
General Structure Information 3zkj ASB9 crystal structure of ankyrin repeat and socs box-containing protein 9 (asb9) in complex with elonginb and elonginc 2.58Å AUTH J.R.C.MUNIZ,K.GUO,N.J.KERSHAW,V.AYINAMPUDI,F.VON DELFT,AUTH 2 J.J.BABON,A.N.BULLOCKTITL MOLECULAR ARCHITECTURE OF THE ANKYRIN SOCS BOX FAMILY OFTITL 2 CUL5-DEPENDENT E3 UBIQUITIN LIGASESREF J.MOL.BIOL. V. 425 3166 2013REFN ISSN 0022-2836PMID 23806657DOI 10.1016/J.JMB.2013.06.015 Variant Set Distributions Ripley’s […]
General Structure Information 2fv2 RQCD1 crystal structure analysis of human rcd-1 conserved region 2.2Å AUTH R.G.GARCES,W.GILLON,E.F.PAITITL ATOMIC MODEL OF HUMAN RCD-1 REVEALS ANTITL 2 ARMADILLO-LIKE-REPEAT PROTEIN WITH IN VITROTITL 3 NUCLEIC ACID BINDING PROPERTIES.REF PROTEIN SCI. V. 16 176 2007REFN ISSN 0961-8368PMID 17189474DOI 10.1110/PS.062600507 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2izv SOCS4 crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution 2.55Å AUTH A.N.BULLOCK,M.C.RODRIGUEZ,J.E.DEBRECZENI,Z.SONGYANG,S.KNAPPTITL STRUCTURE OF THE SOCS4-ELONGINB/C COMPLEX REVEALS ATITL 2 DISTINCT SOCS BOX INTERFACE AND THE MOLECULAR BASIS FORTITL 3 SOCS-DEPENDENT EGFR DEGRADATION.REF STRUCTURE V. 15 1493 2007REFN ISSN 0969-2126PMID 17997974DOI 10.1016/J.STR.2007.09.016 Variant Set Distributions Mapped […]
General Structure Information 3mb4 PBRM1 crystal structure of the fifth bromodomain of human poly-bromodomain containing protein 1 (pb1) with nmp 1.66Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3fkc ZBTB33 crystal structure of human zinc finger and btb domain containing 33 1.7Å AUTH P.FILIPPAKOPOULOS,A.BULLOCK,T.KEATES,N.BURGESS-BROWN,AUTH 2 J.MUNIZ,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN ZINC FINGER AND BTB DOMAINTITL 2 CONTAINING 33REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ys9 HOMEZ structure of the third homeodomain from the human homeobox and leucine zipper protein, homez -1.0Å AUTH S.OHNISHI,T.TOMIZAWA,S.KOSHIBA,T.HARADA,S.WATANABE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL STRUCTURE OF THE THIRD HOMEODOMAIN FROM THE HUMANTITL 2 HOMEOBOX AND LEUCINE ZIPPER PROTEIN, HOMEZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants