Assessment of Structural Intolerance and Durability
General Structure Information 2q87 CD300A the crystal structure of the human irp60 ectodomain 1.7Å AUTH N.DIMASI,J.A.MARQUEZTITL THE CRYSTAL STRUCTURE OF IRP60 ECTODOMAINREF TO BE PUBLISHED 2007REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2os6 ARHGEF12 solution structure of larg pdz domain in complex with c- terminal octa-peptide of plexin b1 -1.0Å AUTH J.LIU,H.HUANG,Y.YANGTITL SOLUTION STRUCTURE OF THE LARG PDZ DOMAIN INTITL 2 COMPLEX WITH C-TERMINAL PEPTIDE OF PLEXIN B1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1n1f IL19 crystal structure of human interleukin-19 1.95Å AUTH C.CHANG,E.MAGRACHEVA,S.KOZLOV,S.FONG,G.TOBIN,S.KOTENKO,AUTH 2 A.WLODAWER,A.ZDANOVTITL CRYSTAL STRUCTURE OF INTERLEUKIN-19 DEFINES A NEW SUBFAMILYTITL 2 OF HELICAL CYTOKINESREF J.BIOL.CHEM. V. 278 3308 2003REFN ISSN 0021-9258PMID 12403790DOI 10.1074/JBC.M208602200 Variant Set Distributions Mapped Variants
General Structure Information 3mop IRAK4 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants
General Structure Information 2yhf CLEC5A 1.9 angstrom crystal structure of clec5a 1.9Å AUTH A.A.WATSON,A.A.LEBEDEV,B.A.HALL,A.E.FENTON-MAY,AUTH 2 A.A.VAGIN,W.DEJNIRATTISAI,J.FELCE,J.MONGKOLSAPAYA,AUTH 3 A.S.PALMA,Y.LIU,T.FEIZI,G.R.SCREATON,G.N.MURSHUDOV,AUTH 4 C.A.OCALLAGHANTITL STRUCTURAL FLEXIBILITY OF THE MACROPHAGE DENGUETITL 2 VIRUS RECEPTOR CLEC5A: IMPLICATIONS FOR LIGANDTITL 3 BINDING AND SIGNALING.REF J.BIOL.CHEM. V. 286 24208 2011REFN ISSN 0021-9258PMID 21566123DOI 10.1074/JBC.M111.226142 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2dhy CUEDC1 solution structure of the cue domain in the human cue domain containing protein 1 (cuedc1) -1.0Å AUTH C.ZHAO,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CUE DOMAIN IN THE HUMANTITL 2 CUE DOMAIN CONTAINING PROTEIN 1 (CUEDC1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lxx GIMAP4 crystal structure of human gtpase imap family member 4 2.15Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.W.ANDREWS,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILYTITL 2 MEMBER 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ux3 FAM96A crystal structure of domain-swapped fam96a minor dimer 1.8Å AUTH K.-E.CHEN,A.A.RICHARDS,J.K.ARIFFIN,I.L.ROSS,M.J.SWEET,AUTH 2 S.KELLIE,B.KOBE,J.L.MARTINTITL THE MAMMALIAN DUF59 PROTEIN FAM96A FORMS TWO DISTINCT TYPESTITL 2 OF DOMAIN-SWAPPED DIMERREF ACTA CRYSTALLOGR.,SECT.D V. 68 637 2012REFN ISSN 0907-4449DOI 10.1107/S0907444912006592 Variant Set Distributions Mapped Variants
General Structure Information 3o4o IL1RAP crystal structure of an interleukin-1 receptor complex 3.3Å AUTH D.L.WANG,S.Y.ZHANG,L.LI,X.LIU,K.R.MEI,X.Q.WANGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND ACTIVATION OFTITL 2 IL-1BETA WITH ITS RECEPTORSREF NAT.IMMUNOL. V. 11 905 2010REFN ISSN 1529-2908PMID 20802483DOI 10.1038/NI.1925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3duh IL23A structure of interleukin-23 2.3Å AUTH P.J.LUPARDUS,K.C.GARCIATITL THE STRUCTURE OF INTERLEUKIN-23 REVEALS THE MOLECULAR BASISTITL 2 OF P40 SUBUNIT SHARING WITH INTERLEUKIN-12.REF J.MOL.BIOL. V. 382 931 2008REFN ISSN 0022-2836PMID 18680750DOI 10.1016/J.JMB.2008.07.051 Variant Set Distributions Mapped Variants