Assessment of Structural Intolerance and Durability
General Structure Information 1smo TREM1 crystal structure of human triggering receptor expressed on myeloid cells 1 (trem-1) at 1.47 . 1.47Å AUTH M.S.KELKER,T.R.FOSS,W.PETI,L.TEYTON,J.W.KELLY,I.A.WILSONTITL CRYSTAL STRUCTURE OF HUMAN TRIGGERING RECEPTOR EXPRESSED ONTITL 2 MYELOID CELLS 1 (TREM-1) AT 1.47A.REF J.MOL.BIOL. V. 342 1237 2004REFN ISSN 0022-2836PMID 15351648DOI 10.1016/J.JMB.2004.07.089 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3w3g TLR8 crystal structure of human tlr8 (unliganded form) 2.3Å AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kgh BPIFA1 crystal structure of human splunc1 lacking the secretion signal sequence 2.81Å AUTH A.L.GARLAND,W.G.WALTON,R.D.COAKLEY,C.D.TAN,R.C.GILMORE,AUTH 2 C.A.HOBBS,A.TRIPATHY,L.A.CLUNES,S.BENCHARIT,M.J.STUTTS,AUTH 3 L.BETTS,M.R.REDINBO,R.TARRANTITL MOLECULAR BASIS FOR PH-DEPENDENT MUCOSAL DEHYDRATION INTITL 2 CYSTIC FIBROSIS AIRWAYS.REF PROC.NATL.ACAD.SCI.USA V. 110 15973 2013REFN ISSN 0027-8424PMID 24043776DOI 10.1073/PNAS.1311999110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3pnw TDRD3 crystal structure of the tudor domain of human tdrd3 in complex with an anti-tdrd3 fab 2.05Å AUTH H.PERSSON,W.YE,A.WERNIMONT,J.J.ADAMS,A.KOIDE,S.KOIDE,R.LAM,AUTH 2 S.S.SIDHUTITL CDR-H3 DIVERSITY IS NOT REQUIRED FOR ANTIGEN RECOGNITION BYTITL 2 SYNTHETIC ANTIBODIES.REF J.MOL.BIOL. V. 425 803 2013REFN ISSN 0022-2836PMID 23219464DOI 10.1016/J.JMB.2012.11.037 Variant Set Distributions Mapped Variants
General Structure Information 3mop MYD88 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants
General Structure Information 1jpy IL17F crystal structure of il-17f 2.85Å AUTH S.G.HYMOWITZ,E.H.FILVAROFF,J.P.YIN,J.LEE,L.CAI,P.RISSER,AUTH 2 M.MARUOKA,W.MAO,J.FOSTER,R.F.KELLEY,G.PAN,A.L.GURNEY,AUTH 3 A.M.DE VOS,M.A.STAROVASNIKTITL IL-17S ADOPT A CYSTINE KNOT FOLD: STRUCTURE AND ACTIVITY OFTITL 2 A NOVEL CYTOKINE, IL-17F, AND IMPLICATIONS FOR RECEPTORTITL 3 BINDING.REF EMBO J. V. 20 5332 2001REFN ISSN 0261-4189PMID 11574464DOI 10.1093/EMBOJ/20.19.5332 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2lnb ZBP1 solution nmr structure of n-terminal domain (6-74) of human zbp1 protein, northeast structural genomics consortium target hr8174a. -1.0Å AUTH Y.YANG,T.A.RAMELOT,K.HAMILTON,E.KOHAN,D.WANG,T.B.ACTON,AUTH 2 R.XIAO,J.K.EVERETT,G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN (6-74) OF HUMANTITL 2 ZBP1 PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 3 TARGET HR8174AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lqt CHCHD7 solution structure of chchd7 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,D.JAISWAL,S.NERI,AUTH 2 R.PERUZZINI,J.WINKELMANNTITL STRUCTURAL CHARACTERIZATION OF CHCHD5 AND CHCHD7: TWOTITL 2 ATYPICAL HUMAN TWIN CX(9)C PROTEINS.REF J.STRUCT.BIOL. V. 180 190 2012REFN ISSN 1047-8477PMID 22842048DOI 10.1016/J.JSB.2012.07.007 Variant Set Distributions Mapped Variants
General Structure Information 1kcg ULBP3 nkg2d in complex with ulbp3 2.6Å AUTH S.RADAEV,B.ROSTRO,A.G.BROOKS,M.COLONNA,P.D.SUNTITL CONFORMATIONAL PLASTICITY REVEALED BY THETITL 2 COCRYSTAL STRUCTURE OF NKG2D AND ITS CLASS ITITL 3 MHC-LIKE LIGAND ULBP3.REF IMMUNITY V. 15 1039 2001REFN ISSN 1074-7613PMID 11754823DOI 10.1016/S1074-7613(01)00241-2 Variant Set Distributions Mapped Variants
General Structure Information 1wgl TOLLIP solution structure of cue domain in the c-terminal of human toll-interacting protein (tollip) -1.0Å AUTH C.ZHAO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF CUE DOMAIN IN THE C-TERMINALTITL 2 OF HUMAN TOLL-INTERACTING PROTEIN (TOLLIP)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants