Assessment of Structural Intolerance and Durability
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i2b PTS the crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase 2.3Å AUTH E.UGOCHUKWU,R.COCKING,E.PILKA,W.W.YUE,J.E.BRAY,A.CHAIKUAD,AUTH 2 T.KROJER,J.MUNIZ,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN 6 PYRUVOYLTITL 2 TETRAHYDROBIOPTERIN SYNTHASEREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2enj PRKCQ solution sturcture of the c2 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STURCTURE OF THE C2 DOMAIN FROM HUMANTITL 2 PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2g9o ATP7A solution structure of the apo form of the third metal- binding domain of atp7a protein (menkes disease protein) -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,N.DELLAMALVA,AUTH 2 T.HERRMANN,A.ROSATO,K.WUTHRICHTITL SOLUTION STRUCTURE AND INTERMOLECULAR INTERACTIONSTITL 2 OF THE THIRD METAL-BINDING DOMAIN OF ATP7A, THETITL 3 MENKES DISEASE PROTEIN.REF J.BIOL.CHEM. V. 281 29141 2006REFN ISSN 0021-9258PMID 16873374DOI 10.1074/JBC.M603176200 […]
General Structure Information 2epa KLF10 solution structure of the first and second zf-c2h2 domains from human krueppel-like factor 10 -1.0Å AUTH K.IZUMI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND ZF-C2H2TITL 2 DOMAINS FROM HUMAN KRUEPPEL-LIKE FACTOR 10REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x4g TIAL1 solution structure of rrm domain in nucleolysin tiar -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RRM DOMAIN IN NUCLEOLYSINTITL 2 TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1b22 RAD51 rad51 (n-terminal domain) -1.0Å AUTH H.AIHARA,Y.ITO,H.KURUMIZAKA,S.YOKOYAMA,T.SHIBATATITL THE N-TERMINAL DOMAIN OF THE HUMAN RAD51 PROTEINTITL 2 BINDS DNA: STRUCTURE AND A DNA BINDING SURFACE ASTITL 3 REVEALED BY NMR.REF J.MOL.BIOL. V. 290 495 1999REFN ISSN 0022-2836PMID 10390347DOI 10.1006/JMBI.1999.2904 Variant Set Distributions Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants