General Structure Information
| PDB ID | 3uvj |
| HGNC Gene Label(s) | GUCY1A3 |
| Structure Name | crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. |
| Resolution | 2.08Å |
| Reference | AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 191 |
| Number Of SNVs | 53 |
| Number Of Permutations | 16963 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.142 |
| p-value | 0.173 |
COSMIC
| Number Of Residues | 191 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1719 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.036 |
| p-value | 0.443 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.216 |
| p-value | 0.186 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
