Assessment of Structural Intolerance and Durability
General Structure Information 2lc3 HECTD1 solution nmr structure of a helical bundle domain from human e3 ligase hectd1. northeast structural genomics consortium (nesg) target ht6305a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.ARROWSMITH,AUTH 2 S.DHE-PAGANONTITL NMR SOLUTION STRUCTURE OF A HELICAL BUNDLE FROM THE E3TITL 2 LIGASE HECTD1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qtl MTRR crystal structure of the fad-containing fnr-like module of human methionine synthase reductase 1.9Å AUTH K.R.WOLTHERS,X.LOU,H.S.TOOGOOD,D.LEYS,N.S.SCRUTTONTITL MECHANISM OF COENZYME BINDING TO HUMAN METHIONINE SYNTHASETITL 2 REDUCTASE REVEALED THROUGH THE CRYSTAL STRUCTURE OF THETITL 3 FNR-LIKE MODULE AND ISOTHERMAL TITRATION CALORIMETRYREF BIOCHEMISTRY V. 46 11833 2007REFN ISSN 0006-2960PMID 17892308DOI 10.1021/BI701209P Variant Set […]
General Structure Information 2ee3 COL20A1 solution structures of the fn3 domain of human collagen alpha-1(xx) chain -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 COLLAGEN ALPHA-1(XX) CHAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dzj TECR 2dzj/solution structure of the n-terminal ubiquitin-like domain in human synaptic glycoprotein sc2 -1.0Å AUTH C.ZHAO,M.YONEYAMA,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL 2DZJ/SOLUTION STRUCTURE OF THE N-TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN IN HUMAN SYNAPTICTITL 3 GLYCOPROTEIN SC2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1sgo GSKIP nmr structure of the human c14orf129 gene product, hspc210. northeast structural genomics target hr969. -1.0Å AUTH T.A.RAMELOT,J.R.CORT,R.XIAO,L.-Y.SHIH,L.-C.MA,AUTH 2 T.B.ACTON,G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE OF THE HUMAN C14ORF129 GENE PRODUCT,TITL 2 HSPC210. NORTHEAST STRUCTURAL GENOMICS TARGETTITL 3 HR969.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dxt SUN2 human sun2 (aa 522-717) 2.22Å AUTH B.A.SOSA,A.ROTHBALLER,U.KUTAY,T.U.SCHWARTZTITL LINC COMPLEXES FORM BY BINDING OF THREE KASH PEPTIDES TOTITL 2 DOMAIN INTERFACES OF TRIMERIC SUN PROTEINS.REF CELL(CAMBRIDGE,MASS.) V. 149 1035 2012REFN ISSN 0092-8674PMID 22632968DOI 10.1016/J.CELL.2012.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oxc DDX20 human dead-box rna helicase ddx20, dead domain in complex with adp 1.3Å AUTH T.KARLBERG,D.OGG,C.H ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,B.M.HALLBERG,AUTH 4 M.HAMMARSTROM,M.HOGBOM,I.JOHANSSON,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,AUTH 6 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,A.G.THORSELL,AUTH 7 S.VAN DEN BERG,J.WEIGELT,L.HOLMBERG-SCHIAVONETITL HUMAN DEAD-BOX RNA HELICASE DDX20REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4lg8 PRPF19 crystal structure of prpf19 wd40 repeats 1.89Å AUTH C.XU,W.TEMPEL,H.HE,E.DOBROVETSKY,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MIN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rip TUBGCP4 crystal structure of human gamma-tubulin complex protein 4 (gcp4) 2.3Å AUTH V.GUILLET,M.KNIBIEHLER,L.GREGORY-PAURON,M.H.REMY,C.CHEMIN,AUTH 2 B.RAYNAUD-MESSINA,C.BON,J.M.KOLLMAN,D.A.AGARD,A.MERDES,AUTH 3 L.MOUREYTITL CRYSTAL STRUCTURE OF GAMMA-TUBULIN COMPLEX PROTEIN GCP4TITL 2 PROVIDES INSIGHT INTO MICROTUBULE NUCLEATION.REF NAT.STRUCT.MOL.BIOL. V. 18 915 2011REFN ISSN 1545-9993PMID 21725292DOI 10.1038/NSMB.2083 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2ibn MIOX crystal structure of human myo-inositol oxygenase (miox) 1.5Å AUTH A.G.THORSELL,C.PERSSON,N.VOEVODSKAYA,R.D.BUSAM,AUTH 2 M.HAMMARSTROM,S.GRASLUND,A.GRASLUND,B.M.HALLBERGTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OFTITL 2 HUMAN MYO-INOSITOL OXYGENASEREF J.BIOL.CHEM. V. 283 15209 2008REFN ISSN 0021-9258PMID 18364358DOI 10.1074/JBC.M800348200 Variant Set Distributions Mapped Variants